Mass COVID-19 patient screening using UvsX and UvsY mediated DNA recombination and high throughput parallel sequencingUVSX 및 UVSY 매개 DNA 재조합 및 높은 처리량 병렬 시퀀싱을 사용한 질량 COVID-19 환자 스크리닝Article Published on 2022-03-082022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus 2019-nCoV Amplicon amplicons amplification approach Bioinformatics analysis Community Containment coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 patient detect develop DNA downstream fatigue Fever foundation Generation Genome High-throughput screening Illumina include individuals Infection Isolation isothermal life-threatening mass Mediated Medical conditions Molecular assay molecular assays non-infectious Novel coronavirus Patient per day platform protocol REcombinase Recombination REMBRANDT respiratory respiratory symptom RNA virus SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shortness of breath Symptom Symptomatic patients [DOI] 10.1038/s41598-022-08034-1 PMC 바로가기 [Article Type] Article
Unusual SARS-CoV-2 intrahost diversity reveals lineage superinfection특이한 SARS-CoV-2 숙주 내 다양성이 혈통 중복 감염을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: Microbial Genomics [Category] SARS, 변종, 치료기술, [키워드] abundance acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach characterized codetection Coinfection coronavirus 2 COVID-19 COVID-19 disease dataset defined detect difficulty distribution epidemiological data Factor Genomics Infection infections investigated Lineage Mutation mutations nine number of sample pandemic phenotype phylogenetically precluded profiles progression provide raw sequencing data Recombination representing respiratory reveal SARS-CoV-2 SARS-CoV-2 lineage sequenced Sequencing sequencing data Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Variability viral lineage viral lineages viral recombination window [DOI] 10.1099/mgen.0.000751 PMC 바로가기 [Article Type] Article
Developing pan-β-coronavirus vaccines against emerging SARS-CoV-2 variants of concern우려되는 신종 SARS-CoV-2 변이체에 대한 범-β-코로나바이러스 백신 개발Article Published on 2022-03-012022-09-11 Journal: Trends in immunology [Category] SARS, 변종, 비임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 clade coronavirus develop Developing Genetic genetic recombination MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus mortality rates Prevalence raise Recombination respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-3 severe acute respiratory syndrome Coronavirus Transmissibility Vaccine β-CoV [DOI] 10.1016/j.it.2022.01.009 PMC 바로가기 [Article Type] Article
Emergence of Within-Host SARS-CoV-2 Recombinant Genome After Coinfection by Gamma and Delta Variants: A Case Report감마 및 델타 변이체에 의한 동시 감염 후 숙주 내 SARS-CoV-2 재조합 게놈의 출현: 사례 보고서Case Reports Published on 2022-02-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, [키워드] Coinfection Combination COVID-19 COVID-19 pandemic Delta emergence emergence of virus Gamma identify iSNVs knowledge Lineage management mapped mosaic Mutation mutations Next-generation sequencing Nucleocapsid gene overlap P.1 Phenotypes public health recombinant Recombination Region report SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 recombination Sequencing sequencing read spike gene supported the SARS-CoV-2 genome variants variants of concern viruses VoC [DOI] 10.3389/fpubh.2022.849978 PMC 바로가기 [Article Type] Case Reports
Genomic Bootstrap Barcodes and Their Application to Study the Evolution of SarbecovirusesArticle Published on 2022-02-212022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] addition Analysis ancestor appear application applied Asia barcode bat bootstrap complicate composed Consensus coronavirus COVID-19 origin COVID-19 pandemic described event Evidence generate Genome genomes genomic genomic region group hidden highlight include Lineage mechanism Phylogenetic phylogenetic support RaTG13 Recombination recombination event Region Reservoir host responsible RmYN02 RNA RNA recombination RNA-dependent RNA polymerase Sarbecoviruses SARS-CoV SARS-CoV-2 supported the SARS epidemic tree reconstruction viral circRNA virus [DOI] 10.3390/v14020440 PMC 바로가기 [Article Type] Article
A novel isothermal method for amplification of long specific amplicon from linear templateArticle Published on 2022-02-172022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] amplification analyzed applied Biological techniques can be used Cre recombinase CREA diagnostic DNA downstream evaluated generate genomic isothermal limit linear nucleic acid amplification Pathogens RCA Recombination RNA RNA templates SARS-CoV-2 spike sequence subsequent Surveillance Variation [DOI] 10.1038/s41598-022-06785-5 PMC 바로가기 [Article Type] Article
Comparative Genomics and Characterization of SARS-CoV-2 P.1 (Gamma) Variant of Concern From Amazonas, BrazilMedicine Published on 2022-02-152022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition Analysis analyzed applied B.1.1.28 Brazil characteristic characterization Comparative concern conducted COVID-19 demonstrated described Efficacy evaluate events Evidence Evolution Gamma Genome Genomic epidemiology Genomics gold standard human SARS-CoV-2 Illumina Miseq immune evasion Laboratory lack likelihood Lineage molecular Mortality Multiple Mutation mutations Neutralizing antibodies no evidence of non-structural protein NSP ORF1a P.1 pathway Patient performed Phylogenetic analysis Phylogenomics platform positive Positive selection Recombination reduced Reinfection Result SARS-CoV-2 selective pressures sequenced sequenced genome Sequencing shown SLAC spike state unique Vaccine variant VoC [DOI] 10.3389/fmed.2022.806611 PMC 바로가기 [Article Type] Medicine
Full Genome Nobecovirus Sequences From Malagasy Fruit Bats Define a Unique Evolutionary History for This Coronavirus Clade마다가스카르 과일박쥐의 전체 게놈 노베코바이러스 서열은 이 코로나바이러스 계통의 독특한 진화 역사를 정의합니다Public Health Published on 2022-02-112022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] Nobecovirus African Analysis Asia Asian bat bat-borne coronavirus bats Betacoronavirus betacoronaviruses carried circulating circulation clades coronavirus defined Endemic Europe Fecal sample fecal samples FIVE fruit Genome genome sequence group history Host hosts indicate individuals landscape madagascar majority metagenomic Mitigation natural reservoirs next generation sequencing nucleocapsid offer Phylogenetic analysis protein region Pteropus Recombination regions reported Research reservoir RNA Rousettus sarbecovirus SARS-CoV sequence Seven subgenus Surveillance Threats unique Urine Viral virus viruses zoonosis zoonotic Zoonotic coronavirus zoonotic coronaviruses [DOI] 10.3389/fpubh.2022.786060 PMC 바로가기 [Article Type] Public Health
Possible recombination between two variants of concern in a COVID-19 patientCOVID-19 환자에서 우려의 두 가지 변종 간의 재조합 가능성Coronaviruses Published on 2022-02-102022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Beta Coinfection COVID-19 patient Delta Evidence evidence of individual intra-host single nucleotide variations ORF1ab Recombination SARS-CoV-2 SARS-CoV-2 variant spike variant variants variants of concern [DOI] 10.1080/22221751.2022.2032375 PMC 바로가기 [Article Type] Coronaviruses
Exploring the Natural Origins of SARS-CoV-2 in the Light of RecombinationResearch Article Published on 2022-02-082022-10-31 Journal: Genome Biology and Evolution [Category] COVID-19, [키워드] Rhinolophus Sarbecoviruses Analysis ancestors antigenic Asia bat bats China circulating collected coronavirus Coronaviruses COVID-19 Determining driving event Evidence facilitated high risk highlight Host host range hotspot Human Humoral immunity lack LIGHT natural origin pangolins performed Phylogenetic Phylogeny proximal Recombination recombination event reveal sarbecovirus Sarbecoviruses SARS-CoV-2 sequence spike the Sarbecovirus the SARS-CoV-2 Transmission Wuhan [DOI] 10.1093/gbe/evac018 PMC 바로가기 [Article Type] Research Article