Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replicationMicrobiology Published on 2014-01-092022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] Chlamydia pecorum absence Alter aminopeptidase N binding CD13 Cell cellular signaling pathway characteristic Chlamydia Chlamydiae chlamydial persistence chlamydial stress response chronic inflammation Co-infection contribute Course Critical Culture cycloheximide de novo demonstrated developmental disease drug epidemic diarrhea experiment Host host cell receptor incubated indicated induce Infected Infection infectious inhibit inhibited non-infectious PEDV performed persistence Porcine epidemic diarrhea virus produced protein synthesis reduced removed Replication replicative required stimulate stressed chlamydiae Vero Cell Viral protein viral replication virus [DOI] 10.3389/fcimb.2014.00020 PMC 바로가기 [Article Type] Microbiology
A Leaderless Genome Identified during Persistent Bovine Coronavirus Infection Is Associated with Attenuation of Gene ExpressionResearch Article Published on 2013-12-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Analysis attenuation Bovine coronavirus Cell culture contribute determined different downstream Efficiency example expression found Frame Genome genomes genomic genomic RNA Identified Infected Infection mutant viruses ORF persistence persistent Postinfection replicative retained RNA selected sequence sgmRNA subgenomic mRNA Transcription translation viral infection was impaired [DOI] 10.1371/journal.pone.0082176 PMC 바로가기 [Article Type] Research Article
Biogenesis and Dynamics of the Coronavirus Replicative StructuresReview Published on 2012-11-212022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association biogenesis cellular membrane complexes coronavirus cytoplasmic detected Dynamics humans Infection infectious agent interior involved knowledge live cell imaging membrane membrane anchoring membrane rearrangements membranes nonstructural protein protein-protein interactions Proteins provided recent replication complex replicative RNA RNA synthesis RNA virus Structure structures Vesicle viral RNA synthesis [DOI] 10.3390/v4113245 PMC 바로가기 [Article Type] Review
Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell CultureResearch Article Published on 2010-11-042022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activity Antiviral arteritis arterivirus Author binding block both viruses catalyzed Cell Cell culture Combination complex complexes Concentration described divalent cation E. coli eliminating enzyme equine found function host proteins impair in vitro activity in vitro study include Increased Increasing Infected Influenza virus inhibit inhibited inhibitory effect Ionophore molecular nidovirus Nsp12 Nsp9 Pathogens plasma Poliovirus polymerases polyprotein polyproteins Proteolytic processing protocol provide purified RdRP RdRps reduced related Replication replication complex replicative Research reversed RNA RNA synthesis RNA viruses RNA-dependent RNA polymerase RTC SARS-coronavirus SARS-CoV target Transcription Transport variety Viral RNA virus Zinc Zn [DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivoResearch Published on 2009-08-242022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA [DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research