Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lungResearch article Published on 2021-12-032022-10-05 Journal: Cell [Category] 비임상, [키워드] anamnestic anamnestic antibody antibody B cells BAL Blood boost Bronchoalveolar lavage COVID-19 declined Delta dependent on Efficacy immune response immunized lower airway lower airways lung mRNA vaccine mRNA-1273 mRNA-1273 vaccine mucosal immunity nasal swabs Neutralizing titer nonhuman primates protection Rapid remained responses rhesus macaque RNA SARS-CoV-2 sgRNA sustained T cell response T cells vaccination virus was reduced [DOI] 10.1016/j.cell.2021.12.002 [Article Type] Research article
Environmental Change and Zoonotic Disease Risk at Human-Macaque Interfaces in BangladeshArticle Published on 2021-12-012023-06-22 Journal: EcoHealth [Category] 조류인플루엔자, [키워드] Anthropogenic changes Human-wildlife interface Qualitative rhesus macaque [DOI] 10.1007/s10393-021-01565-5 PMC 바로가기
Evaluation of the Relationship between Clonal Hematopoiesis and Severe COVID-19 Disease in Rhesus MacaquesConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] Acquired advanced age age Analysis Asymptomatic autologous Autopsy BAL benefit Blood clinical manifestation clinical symptom clinically co-morbidities cohort study Concentration Control control group controls COVID-19 COVID-19 disease detectable develop died disease Evidence expand Factor Genes group hallmark Hematopoiesis Human Hyperinflammatory IL-6 IL-6 level IL-8 Infection Inflammation inoculated Laboratory LOF loss of function lung tissue macaque MCP-1 Mild MIP-1b Multiorgan mutant Mutation occur pathophysiological pathophysiology phenotype progenitor cell relationship reported Respiratory failure Respiratory samples rhesus macaque risk risk factor robust Sample size SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sera severe COVID-19 severe COVID-19 disease severe COVID-19 illness significant difference somatic mutation suggested Symptom TET2 the median therapeutic approaches therapy Vaccine development Viral antigen [DOI] 10.1182/blood-2021-152628 [Article Type] Conference abstract
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation단일 클론 항체는 SARS-CoV-2 유도 면역 활성화 및 신경 염증으로부터 늙은 붉은털 원숭이를 보호합니다Article Published on 2021-11-022022-09-12 Journal: Cell Reports [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Administered antibody block CD4 cerebrospinal cerebrospinal fluid chemokine consequence coronavirus coronavirus disease COVID-19 curtail dampen diabete Diabetic effector CD4 T cells Efficacy greater high-risk population immune activation Immunity increase in Inflammatory interstitial interstitial pneumonia Lower respiratory tract Lymph node mAb mitigate monoclonal antibody NeuroCOVID, inflammation Neuroinflammation Neutralizing Pathogenesis Population populations Prophylactic PROTECT reducing rhesus macaque rhesus macaques SARS-CoV-2 significantly T cell T cell activation Treatment viral replication [DOI] 10.1016/j.celrep.2021.109942 PMC 바로가기 [Article Type] Article
Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques붉은 털 원숭이의 비강 및 기관 내 SARS-CoV-2 감염에 대한 위장 SARS-CoV-2 전달의 보호 효능Vaccines and Antiviral Agents Published on 2021-10-272022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus administration Antibody titer Bronchoalveolar lavage fluid challenge conducted coronavirus correlated Coverage COVID-19 delivery distribution Efficacy esophagogastroduodenoscopy Formulation Gastrointestinal gastrointestinal tract greater health benefits immunogenic immunogenicity intranasal intratracheal live oral vaccine Live oral vaccines live SARS-CoV-2 macaque mucosal nasal swab nasal swabs offer oral administration Oral vaccine Prophylactic Protective protective efficacy public health Rectal swabs respiratory viruses rhesus macaque rhesus macaques route SARS-CoV-2 serotype Serum neutralizing antibody severe acute respiratory syndrome Coronavirus timelines Vaccine Vaccines Viral load virus replication [DOI] 10.1128/JVI.01599-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal modelsArticle Published on 2021-10-232022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS, [키워드] Abstract Against animal challenge animal model Antibody Response antigenic antigens Beta Beta variant boost booster Cell Critical cross-neutralizing antibody response disease Efficacy elicit Evidence Heterologous Heterotypic heterotypic boost Humoral immunity immunization immunized Infection K18-hACE2 mice macaque memory B neutralizing antibody Neutralizing antibody response original antigenic sin outcome pandemic passive immunization passive transfer plasma PROTECT Protein RBD Receptor binding domain reduced response restored rhesus macaque SARS-CoV-2 SARS-CoV-2 variant single dose Spread subsequent Vaccine Vaccines variant variants of concern VoC VOCs widespread [DOI] 10.1016/j.xcrm.2021.100450 PMC 바로가기 [Article Type] Article
Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaquesResearch Article Published on 2021-10-222022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] absence animal B.1 B.1.1.7 B.1.351 bronchoalveolar can be used caused changes in chemokine circulation clinical disease confounding factors cytokine D614G description Efficacy favor immune evasion inoculated inoculation less lung lung lesions Medical countermeasures nasal samples pathogenicity phenotypical Replication respiratory tract rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 variant severe disease Transmissibility up-regulated variants of concern virus titers VoC [DOI] 10.1126/sciadv.abj3627 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaquesAd26.COV2.S 백신 접종 후 SARS-CoV-2 결합 및 중화 항체 수준은 붉은털 원숭이의 지속적인 보호를 예측합니다Article Published on 2021-10-072022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Analysis Antibody titer Antibody titers approval authorization binding clinical development COVID-19 vaccine Efficacy Emergency use Evidence Human Immunity immunization immunogenicity immunological indicate knowledge Limited lung Lungs macaque natural infection Neutralizing antibodies neutralizing antibody other coronavirus other coronaviruses post vaccination predict predicted Predictive markers preliminary evidence Protective Protein Replication replication of SARS-CoV-2 rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selected short-lived spike Spike protein the SARS-CoV-2 vaccination Vaccine Vaccines variant vector viral infection [DOI] 10.1038/s41467-021-26117-x PMC 바로가기 [Article Type] Article
Similarities and Differences in the Acute-Phase Response to SARS-CoV-2 in Rhesus Macaques and African Green MonkeysImmunology Published on 2021-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absolute monocyte count acute response African African green monkey AGM AGMs alteration Analysis Blood breadth Cohort Correlation analysis COVID-19 COVID-19 disease Critical defined difference effective vaccine Evidence exhibiting gene network greater green hallmark help immune Infection interferon ISG ISGs macaque Monkey nasopharyngeal neutrophil (PMN) neutrophil degranulation NHP normalized occurred outcome pathology pathway Post-infection presenting Pulmonary pathology Regulation response rhesus macaque SARS-CoV-2 SARS-COV-2 infection similarity stimulated Systems biology timepoint transcriptional transcriptional change Transcriptome type I understanding upregulation WGCNA [DOI] 10.3389/fimmu.2021.754642 PMC 바로가기 [Article Type] Immunology
A Meta-Analysis of Rhesus Macaques ( Macaca mulatta), Cynomolgus Macaques ( Macaca fascicularis), African green monkeys ( Chlorocebus aethiops), and Ferrets ( Mustela putorius furo) as Large Animal Models for COVID-19붉은털원숭이( Macaca mulatta), Cynomolgus Macaques( Macaca fascicularis), 아프리카 녹색원숭이(Chlorocebus aethiops), 흰족제비( Mustela putorius furo)를 COVID-19의 대형 동물 모델로 메타 분석Meta-Analysis Published on 2021-10-012022-09-12 Journal: Comparative medicine [Category] MERS, SARS, 진단, [키워드] African green monkey animal animal model Biomedical research Chlorocebus COVID-19 COVID-19 symptom cynomolgus macaque Day disease effort evaluate expand ferret Fisher exact test Frequency Human identify incidence include lack Leukocytosis macaque Meta-analysis Model null hypothesis Pathogenesis pathology Pneumonia Research rhesus macaque Standardization vaccine immunogenicity Vaccines Viral transmission [DOI] 10.30802/AALAS-CM-21-000032 PMC 바로가기 [Article Type] Meta-Analysis