Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach분자 도킹 및 MM/GBSA 접근법을 통한 SARS-CoV-2 스파이크 단백질의 비동의적 돌연변이 및 ACE2 수용체와의 상호작용 조사Article Published on 2021-08-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor acute respiratory distress acute respiratory distress syndrome angiotensin angiotensin-converting enzyme 2 approach approaches binding binding affinity binding free energy bioinformatics caused coagulation dysfunction COVID-19 D614G develop disease docking domain examined free energy G476S help Host human cell human cells in viral Infection infectious interact Interaction investigated investigation L18F MDs MERS-CoV molecular docking molecular dynamics Molecular dynamics simulation molecular mechanism mutant mutants Mutation N501Y nonsynonymous mutation Nonsynonymous mutations pathogenic pathological mechanism Perspective RBD receptor Receptor-binding domain researcher respiratory distress responsible reveal S-protein SAR-CoV-2 SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic screened Septic shock spike Spike protein spike-protein stability syndrome the spike protein Treatment viral disease viral infection virulent [DOI] 10.1016/j.compbiomed.2021.104654 PMC 바로가기 [Article Type] Article
Chemotherapy resumption in breast cancer patient after COVID-19Case Report Published on 2021-07-212022-10-28 Journal: Surgical Case Reports [Category] COVID-19, [키워드] adverse event anti-cancer treatment Breast cancer Cancer cancer patient cancer treatment Case report Chemotherapy clinical information Clinical symptoms Course COVID-19 COVID-19 patients discharge Evaluating Fever had no Hospitalized Infection initial invasive Japanese Patient patients with COVID-19 positive recovering from COVID-19 regimen Resumption risk RT-PCR SAR-CoV-2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 tested therapy while [DOI] 10.1186/s40792-021-01253-0 PMC 바로가기 [Article Type] Case Report
Clinical Characteristics, Management, and Short-Term Outcome of Neonates Born to Mothers with COVID-19 in a Tertiary Care Hospital in India인도 3차 병원에서 코로나19 산모에게서 태어난 신생아의 임상적 특성, 관리 및 단기 결과Article Published on 2021-07-022022-09-11 Journal: Journal of tropical pediatrics [Category] SARS, 치료기술, [키워드] 95% CI adverse outcome adverse outcomes Birth weight Care clinical Clinical characteristics confidence interval COVID-19 death deaths gestation higher risk hospital India management Maturity mother Mumbai Neonatal neonatal death neonatal outcome neonatal sepsis Neonate Neonates Newborn Newborns no significant differences occurred outcome Poor feeding Retrospective analysis risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection Sepsis Sex significant difference significant differences significantly more Tertiary the SARS-CoV-2 with COVID-19 [DOI] 10.1093/tropej/fmab054 PMC 바로가기 [Article Type] Article
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral InfectionSARS-CoV-2 바이러스 감염 중 자가항원 발현 향상Immunology Published on 2021-06-302022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation Analysis Asymptomatic COVID-19 autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity Autopsy bioinformatics Blood conducted confirmed case confirmed cases COVID-19 COVID-19 infections datasets determine Effect enhanced evaluate expression level expression levels follow-up studies follow-up study homeostasis IFIH1 Immune homeostasis immunopathology in-silico Infection infections lead longitudinal low-density lung lung autopsies mononuclear cell mononuclear cells MPO neutrophil neutrophil activation overexpressed PADI4 PBMCs Peripheral blood Peripheral blood mononuclear cells plasma protein protein level protein levels PRTN3 PTPRN2 respiratory viral infection SAR-CoV-2 SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 infections severity of COVID-19 significantly single-cell dataset subset tissue Tolerance transcriptomic TRIM21 TSHR upregulated upregulation Viral viral infection viral infections Whole blood [DOI] 10.3389/fimmu.2021.686462 PMC 바로가기 [Article Type] Immunology
Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds폐수에서 SARS-CoV-2 RNA와 하수구의 COVID-19 질병 부담의 상관관계Article Published on 2021-06-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] 1.26 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assist cause Characteristics Community conducted coronavirus coronavirus disease Correlation analysis COVID-19 COVID-19 case COVID-19 cases detectable disease Disease burden Epidemiology Evidence evidence of feces frequencies increase in individual infiltration inflow Interceptor outbreak positively correlated Public health response Public health responses Ribonucleic acid RNA SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus sewershed urban Utah utility viral ribonucleic acid virus wastewater wastewater epidemiology with COVID-19 [DOI] 10.1016/j.scitotenv.2021.145790 PMC 바로가기 [Article Type] Article
Dietary Behaviors and Incident COVID-19 in the UK BiobankArticle Published on 2021-06-202022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted age association average baseline Behavior Breastfeeding coffee COVID-19 COVID-19 test dietary England Epidemiology examined Factor Factors Immunity incident independent individual influence limit lowest multivariable nutrition participant PCR polymerase chain positive processed Public Health England quartile real time remained SAR-CoV-2 socio-demographic Spread susceptibility swabs tested UK biobank UKB virus [DOI] 10.3390/nu13062114 PMC 바로가기 [Article Type] Article
Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern우려되는 SARS-CoV-2 변이체에 대한 중화 항체의 에피토프 분류 및 RBD 결합 특성Immunology Published on 2021-06-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding ACE2 binding affinity acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis angiotensin angiotensin converting enzyme antibody bind binding binding affinity binding epitope C1D cause Cell classification concern coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID19 death disease disrupting E484K ENhance enzyme epitope mapping Epitopes evade evaluated exhibited Host immune response hosts interactions L452R less mutant N501Y NAb NAbs Naturally Neutralizing antibodies neutralizing antibody P.1 predict promote property Protein quantified RBD RBD binding RBD variant RBD variants Receptor binding domain representing respiratory responsible SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 WT sensitivity sequence variation Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Strains surface area susceptible susceptible hosts the RBD the SARS-CoV-2 therapeutic option Treatment variant variant of concern Viral viral infectivity viral pathogenesis while Wuhan-1 [DOI] 10.3389/fimmu.2021.691715 PMC 바로가기 [Article Type] Immunology
Symptom and Age Homophilies in SARS-CoV-2 Transmission Networks during the Early Phase of the Pandemic in JapanArticle Published on 2021-06-032022-10-28 Journal: Biology [Category] COVID-19, [키워드] Affect affected Analysis analyzed Asymptomatic asymptomatic patients Cell conducted Contact Contact tracing COVID-19 COVID-19 pandemic demographic homogeneities and heterogeneities early stage epithelial expected exponential random graph model (ERGM) network analysis genetic difference healthcare Homophily individual Infection initial Japan network network analysis occurred pandemic Pathogenesis Patient patients PCR analysis phase random registry data Retrospective study SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 transmission shown simple Symptom symptomatic symptomological homogeneities and heterogeneities temperature Transmission variable Viral transmission viral transmission networks virus was performed [DOI] 10.3390/biology10060499 PMC 바로가기 [Article Type] Article
The utility of video technology and enhanced infection control in reducing COVID-19 disease burden in a custodial settingArticle Published on 2021-06-012023-07-05 Journal: American journal of infection control [Category] SARS, [키워드] Contact tracing Digital Juvenile prevention SAR-CoV-2 technology video [DOI] 10.1016/j.ajic.2020.10.016 PMC 바로가기
Animal models for SARS-Cov2/Covid19 research-A commentarySARS-Cov2/Covid19 연구용 동물 모델-A 논평Review Published on 2021-06-012022-09-11 Journal: Biochemical pharmacology [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 addition animal animal model BALB/c cellular receptor clearance clinical feature Clinical features Co-infection Combination COVID 19 COVID-19 COVID-19 disease COVID-19 pathogenesis Critical disease drugs Effect FCgRT Gene Expression hematologic homolog humanized Immunity IMPROVE Infection Initiation codon knock-out Lung pathology mechanism modeling mouse model Multigene humanized mouse models offer pathology platform Precision preparation primary antibody protease random receptor receptors Research researcher Responder responders resulting SAR-CoV-2 SARS CoV SARS CoV-2 SARS CoV-2 infection selected strain suggested targets Th1 Th2 therapeutic efficacy TMPRSS2 TMRPSS2 transgene transgenic model unnatural Vaccine Variability [DOI] 10.1016/j.bcp.2021.114543 PMC 바로가기 [Article Type] Review