Similar Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Similar Nucleocapsid Antibody Levels in People With Well-Controlled Human Immunodeficiency Virus (HIV) and a Comparable Cohort of People Without HIV중증 급성 호흡기 증후군 코로나바이러스 2 감염의 유사한 위험 및 인간 면역결핍 바이러스(HIV)가 잘 통제된 사람들과 유사한 HIV가 없는 사람들의 유사한 뉴클레오캡시드 항체 수준Comparative Study Published on 2022-06-012022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African age antibody both groups CD4 cell clinical Cohort comparable complementary coronavirus coronavirus 2 COVID-19 cumulative cumulative incidence Fever group HIV HIV-negative HIV-positive individual HIV-positive individuals Human Human immunodeficiency virus immunodeficiency virus Immunoglobulin incidence Infection Level Linear regression nucleocapsid participant Participants positive individuals respiratory risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N antibody SARS-CoV-2 nucleocapsid serology severe acute respiratory syndrome Coronavirus starting suppressed Trial Viremia were assessed [DOI] 10.1093/infdis/jiab616 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 Immunohistochemistry In Placenta태반의 SARS-CoV-2 면역조직화학Article Published on 2022-06-012022-09-11 Journal: International journal of surgical pathology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] COVID-19 delta variant diagnosing dominant electron microscopy immunohistochemistry Infection nucleocapsid nucleocapsid protein parental pathology Placenta placental Placental infection pregnant women Protein robust SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Spike protein ultrastructure [DOI] 10.1177/10668969211067754 PMC 바로가기 [Article Type] Article
Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2SARS-CoV-2에 감염된 폐 이식 수혜자의 감시 생검에서 병리학적 소견의 진화Article Published on 2022-06-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Admission alteration biopsy Bronchiolitis bronchiolitis obliterans case sery coronavirus disease Coronavirus disease 2019 COVID-19 described determine Diagnosis died Evolution Follow-up GRADE heart histology Hospitalized ICU immunofluorescence inclusion criteria infected with SARS-CoV-2 intensive care intensive care unit large cohort lung Lung injury lung transplant lung transplantation non-transplant patient non-transplant patients one patient Organizing pneumonia outcome outcomes pathologic pathological finding pathology Patient positive Prognosis Protein recipient recipients rejection respiratory pathogen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Society specimen subset Surveillance Symptomatic patients tested transbronchial Transplant Two patient two patients was performed [DOI] 10.1111/tid.13823 PMC 바로가기 [Article Type] Article
Monitoring COVID-19 spread in Prague local neighborhoods based on the presence of SARS-CoV-2 RNA in wastewater collected throughout the sewer network하수도 네트워크를 통해 수집된 폐수에서 SARS-CoV-2 RNA의 존재를 기반으로 프라하 인근 지역의 COVID-19 확산 모니터링Article Published on 2022-06-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 치료법, [키워드] airport carried Chain Reaction collected correlation COVID-19 COVID-19 case COVID-19 epidemic determined by Epidemic Epidemiology gene encoding hospitals hotspot identify Local monitoring multiplex nucleic acid nucleic acids Occurrence plant polymerase chain polymerase chain reaction Prague Precipitation Quantitative reagent Registered reported reverse transcription RNA isolation RT-mqPCR SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA selected shown Spread Treatment TRIzol™ Reagent upstream was determined wastewater Wastewater-based epidemiology [DOI] 10.1016/j.watres.2022.118343 PMC 바로가기 [Article Type] Article
Multiplexed flow cytometric approach for detection of anti-SARS-CoV-2 IgG, IgM and IgA using beads covalently coupled to the nucleocapsid protein뉴클레오캡시드 단백질에 공유 결합된 비드를 사용하여 항-SARS-CoV-2 IgG, IgM 및 IgA의 검출을 위한 다중 유동 세포측정 접근법Article Published on 2022-06-012022-09-11 Journal: Letters in Applied Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] anti-IgG anti-IgM anti-SARS-CoV-2 IgG antibody approach biotinylated CBA CBA functional beads condition COVID-19 COVID-19 negative Cytometry Diagnosis Flow flow cytometric flow cytometry functional IgA IgA antibodies IgA2 IgG IgM IgM and IgA antibodies immunoassay Immunoglobulin Immunoglobulin G multiplex multiplex immunoassay. nucleocapsid protein opens positive Protein SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 nucleocapsid secondary antibodies sensitivity specificity streptavidin were used [DOI] 10.1111/lam.13674 PMC 바로가기 [Article Type] Article
Identification and application of a pair of noncompeting monoclonal antibodies broadly binding to the nucleocapsid proteins of SARS-CoV-2 variants including OmicronOmicron을 포함한 SARS-CoV-2 변이체의 뉴클레오캡시드 단백질에 광범위하게 결합하는 비경쟁 단일클론항체 쌍의 확인 및 적용Article Published on 2022-05-282022-09-11 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] Alpha Analysis Antigen Beta binding biochemical assay Clinical diagnosis Delta enzyme Epitopes evaluated flow cytometry focus highlighting identification immunofluorescence immunosorbent linear epitope Live virus mAb mAbs monoclonal antibody neutralization neutralization test nucleocapsid protein omicron pair Protein recognizing reduction reported SARS-CoV SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 variant SARS-CoV-2 variants virus infection viruses western blot [DOI] 10.1186/s12985-022-01827-w PMC 바로가기 [Article Type] Article
A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cellsSARS-CoV-2 뉴클레오캡시드의 새로운 인산화 부위는 숙주 세포에서 RNA 결합 능력과 상 분리를 조절합니다Article Published on 2022-05-202022-09-11 Journal: Journal of Molecular Cell Biology [Category] COVID19(2023년), SARS, 치료법, [키워드] host cell Phosphorylation regulate SARS-CoV-2 nucleocapsid [DOI] 10.1093/jmcb/mjac003 PMC 바로가기 [Article Type] Article
Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질을 표적으로 하는 새로운 인간 항체의 구조 유도 친화성 성숙Article Published on 2022-05-192022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation antibody binding biological function BLI candidate complex conserved Diagnosis diagnostic effective Evidence expected genome sequence global pandemic higher affinity homology Interaction linker magnitude marker molecular docking mutant Mutation N protein nucleocapsid protein pandemic peptide predicted Prevention and control Protein recent recognize residue SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-CoV-2 pandemic scFv shown Structure the N protein the SARS-CoV-2 therapeutic drug Treatment was tested [DOI] 10.1038/s41598-022-12242-0 PMC 바로가기 [Article Type] Article
Detecting anti-SARS-CoV-2 antibodies in urine samples: A noninvasive and sensitive way to assay COVID-19 immune conversion소변 샘플에서 항-SARS-CoV-2 항체 검출: COVID-19 면역 전환을 분석하는 비침습적이고 민감한 방법Article Published on 2022-05-132022-09-11 Journal: Science Advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] (enzyme-linked immunosorbent assay acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies can be used coronavirus COVID-19 detect ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay house immune in urine individual level investigated noninvasive Patient platform population level Protein respiratory risk of infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid sensitivity serum specificity Urine virus-specific antibodies [DOI] 10.1126/sciadv.abn7424 PMC 바로가기 [Article Type] Article
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms감염 또는 신경학적 증상이 없는 대조군과 비교하여 COVID-19 감염 및 신경학적 증상이 있는 환자의 뇌척수액에서 바이러스 항원 및 염증성 바이오마커Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 95% CI age Antigen Biomarker capture Central nervous system cerebrospinal fluid clinical CNS component Concentration contribute Control control group controls correlated COVID COVID-19 COVID-19 infection COVID-19 severity cross-sectional cross-sectional study CSF Cytokines detectable disease severity Encephalopathy Evidence evidence of Gothenburg Health Organization healthy control highlight IL-10 IL-6 immune activation immune response immune responses immunoassay Infection Inflammatory Inflammatory biomarker inflammatory biomarkers Injury interferon interferon γ interleukin IQR male median microglobulin moderate Moderate COVID-19 Necrosis neurologic neuronal no differences nucleocapsid antigen Older outcome participant Participants Pathogenesis Patient patient groups platform Principal component principal component analysis Protein Sahlgrenska University Hospital SARS-COV-2 infection SARS-CoV-2 nucleocapsid scale severe COVID-19 severe disease significantly significantly higher Study protocol Swedish Symptom Symptoms test results Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Viral Viral antigen viral invasion Viral RNA was performed with COVID-19 World Health Organization β2-microglobulin [DOI] 10.1001/jamanetworkopen.2022.13253 PMC 바로가기 [Article Type] Article