Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort StudyCardiology Published on 2021-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI absolute lymphocyte antiplatelet approach assessment benefit Blood urea nitrogen BMI body mass index Cancer Combined Complication coronavirus disease COVID-19 COVID-19 patient COVID-19 patients criteria D-dimer D-dimer level D-dimers deep Deep vein thrombosis diagnose diagnosing Diagnosis DVT Embolism failure Gender intubation Level male material Occurrence outcome Patient patients PE group Platelet positive Prevalence Primary outcome pulmonary Pulmonary embolism Result risk factor score secondary sensitivity severity SOFA specificity statistically significant systemic inflammation Systolic blood pressure Thromboembolism utility Vein VTE WBC well wells dvt score wells pe score [DOI] 10.7759/cureus.17687 PMC 바로가기 [Article Type] Cardiology
Soluble urokinase plasminogen activator receptor (suPAR) predicts critical illness and kidney failure in patients admitted to the intensive care unitArticle Published on 2021-09-012022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] 28-day mortality association Coagulation consecutive patient COVID-19 Critical critically ill patients Diagnosis doubling estimate highest ICU ICU admission ICU patient Infectious diseases inflammation markers Inflammatory biomarker intensive care Interaction Kaplan–Meier kidney Kidney disease Kidney diseases Liver disease lowest moderate Mortality non-survivor Occurrence Odds ratio offer organ dysfunction Organ failure Patient performed plasma suPAR predict Prognostic markers Prognostic value Prospective Study quartile random receptor reflected risk factor risk stratification Secondary objective Sepsis SOFA SOFA score subgroups suPAR survival survivor [DOI] 10.1038/s41598-021-96352-1 PMC 바로가기 [Article Type] Article
Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study중환자실에 입원한 COVID-19 중환자의 임상 예후 조사: 사우디 전국 연구Multicenter Study Published on 2021-08-262022-09-12 Journal: Medicina [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis assessment BMI caused Characteristics clinical Clinical characteristics Co-infection Cohort Comorbidity Complication conducted coronavirus cough COVID-19 COVID-19 patient critical cases Critically ill critically ill COVID-19 patients demonstrated determine diabete diabetes ECMO Examining extracorporeal membrane oxygenation failure Fever followed by Frequency fungal greater heart disease high mortality hospitals hypertension ICU ICUs Ill Infectious disease intensive care unit intensive care units ischemic heart disease majority male material mechanical ventilation medical history MOST multicenter Multiple non-survivor Non-survivors objective outcome overall mortality Patient predicted prognostic Result Retrospective study RNA coronavirus SARS-CoV-2 Saudi Arabia severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Shortness of breath significantly single-stranded smoking SOFA survival survivor ventilatory ventilatory support with COVID-19 [DOI] 10.3390/medicina57090878 PMC 바로가기 [Article Type] Multicenter Study
The prognostic value of the SOFA score in patients with COVID-19 A retrospective, observational studyObservational Study Published on 2021-08-132022-10-04 Journal: Medicine [Category] MERS, 임상, [키워드] Accuracy acute respiratory syndrome Admission advanced age Analysis analyzed ARDS assessment AUC calculated chronic liver disease clinical Clinical characteristics clinical manifestations Clinical outcome collected Comorbidities complications Coronary heart disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients Cox proportional hazard Cutoff cutoff value death diabete diagnose diagnosed with COVID-19 diagnostic discharged dry cough evaluate exhibited failure Fever greater group hypertension identify In-hospital death independent risk factor intensive care interquartile range IQR Kaplan–Meier method Laboratory Laboratory results median median age Mild Mortality mortality rate multiple organ failure multivariate logistic regression Odds ratio Patient patients died patients with COVID-19 performed predict Prognosis Prognostic value receiver operating characteristic Regression retrospective risk factor Risk factors risk of death ROC ROC Curve SARS-CoV-2 severe COVID-19 severity severity and prognosis significantly significantly higher SOFA SOFA score SOFA scores stroke survival survival analysis Symptom the log-rank test the patient used to evaluate variable was performed was used were assessed [DOI] 10.1097/MD.0000000000026900 PMC 바로가기 [Article Type] Observational Study
Identifying organ dysfunction trajectory-based subphenotypes in critically ill patients with COVID-19COVID-19 중환자의 장기 기능 장애 궤적 기반 하위 표현형 식별Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] assessment baseline Biomarker Central nervous system Clustering Coagulation COVID-19 COVID-19 patient Critical Critical illness Critically ill patient defined detect dynamic dysfunction evaluate evaluated failure hemophagocytic lymphohistiocytosis heterogeneous hospital host response identify identifying Inflammation Intubated Intubated COVID-19 patients intubation liver measure Mild Mortality New York New York City offer organ dysfunction organ systems outcome pathogenic pathophysiology Predictive Prognosis progression renal Respiration respiratory Respiratory failure Sequential Organ Failure Assessment severe COVID-19 severity severity of illness similarities similarity SOFA SOFA score time trajectory understanding validation cohorts viral infection was performed with COVID-19 worsening [DOI] 10.1038/s41598-021-95431-7 PMC 바로가기 [Article Type] Article
Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort StudyImmunology Published on 2021-08-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] 95% CI 95%CI Acute kidney injury acute respiratory distress AKI ARDS China confounding factors COVID-19 COVID-19 patient disease severity Efficacy FIVE greater hospital ICU ICU admission in-hospital mortality rate incidence increased risk intensive care intubation rate multicenter cohort study non-recovery Organ failure outcomes paO2/fiO2 Patient patients with COVID-19 performed Primary outcome Result significantly significantly higher SOFA subgroup syndrome the patient therapy thymosin alpha 1 treat treatment group was used [DOI] 10.3389/fimmu.2021.673693 PMC 바로가기 [Article Type] Immunology
Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trialRandomized Controlled Trial Published on 2021-08-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] 1:1 ACEi ACEIs Admission angiotensin-converting enzyme 2 ARBs assigned AUC blocker cardiovascular center Course COVID-19 dead death died eight Endpoint enrolled faster females Germany had no human cell Hypothesis inhibitor intensive care mechanical ventilation median median age mitigate modified intention-to-treat no significant difference Older Open-label organ dysfunction Organ failure outcome parallel group Patient patients died randomised Randomly RAS receptor Registered renin-angiotensin system risk SARS-CoV-2 entry Science scored secondary severity of COVID-19 significant effect significantly lower SOFA SOFA score symptomatic SARS-CoV-2 infection the primary endpoint therapy treated Treatment Trial upregulated [DOI] 10.1016/S2213-2600(21)00214-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Elevated plasma ICAM1 levels predict 28-day mortality in cirrhotic patients with COVID-19 or bacterial sepsisResearch article Published on 2021-08-012022-10-05 Journal: JHEP Reports [Category] 바이오마커, [키워드] 28-day mortality 95% CI aetiology alcohol AUC Bacterial sepsis Biomarker Biomarkers cirrhosis Coagulation COVID-19 Critically ill detrimental diagnostic dysfunction elevated endothelial endothelial injury Factor growth factor hazard ratio high plasma level hospitalized patient ICAM1 ICU ICU admission increased mortality independent indicate Infection infections Injury intensive care intercellular investigated liver Liver cirrhosis Liver disease Mortality not differ Organ failure Pathogenesis Patient patients patients with COVID-19 plasma positively correlated predict predicted predictor prognostic biomarker Prognostic value receptor recorded reduced renal reported Result Sepsis severe COVID-19 significantly SOFA subgroup of patients Vascular VEGFR1 von Willebrand factor was increased [DOI] 10.1016/j.jhepr.2021.100303 [Article Type] Research article
Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortalityproapoptotic sFas 및 antiapoptotic Bcl2 및 COVID-19 환자 사망률의 혈중 농도Observational Study Published on 2021-08-012022-09-11 Journal: Expert review of molecular diagnostics [Category] MERS, 바이오마커, 임상, [키워드] 95% CI antiapoptotic APACHE association BCl2 best blood concentration Blood level blood levels Canary Island Canary Islands circulating Concentration COVID-19 patient COVID-19 patients COVID-19: patients determine eight extrinsic pathway ICU ICU admission intensive care unit intrinsic pathway knowledge Logistic regression Mortality Patient Prospective Study Protein serum serum concentrations serum levels sFas. SOFA Spain was performed [DOI] 10.1080/14737159.2021.1941880 PMC 바로가기 [Article Type] Observational Study
Prediction of 28-day mortality in critically ill patients with COVID-19: Development and internal validation of a clinical prediction modelResearch Article Published on 2021-07-132022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 28-day mortality Admission admitted to ICU age bootstrap C-statistic Cohort Comorbidity COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients critical COVID-19 patients Critically ill Critically ill patient death develop development diabete diagnosis of SARS-CoV-2 died disease evaluate evaluated expected Factors Hospitalization ICU admission ICUs independent predictor intensive care unit internal IQR Laboratory mandatory material Mortality multivariable multivariable Cox regression multivariable model obesity PaO paO2/fiO2 Patient Pneumonia prediction Predictive Probability procalcitonin prognostic model required Result SOFA SOFA score the median variables was performed [DOI] 10.1371/journal.pone.0254550 PMC 바로가기 [Article Type] Research Article