A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection
네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.
Immunology
[키워드] 2019
activating
Antiviral
antiviral response
approach
bind
bioinformatics
cause
Cell
Cluster
Combination
coronavirus
COVID-19
Critical
cytokine
Cytokine storm
Cytokines
Defense
depth analysis
differentially expressed
epithelial
experimental validation
expression
Extensive
fibrosis
finding
Functional enrichment analysis
generate
Genes
highest
host gene
host genes
host response
human immune response
IFN-α
immune
in-depth analysis
infect
Inflammatory
Inflammatory response
inhibit
initiate
ISGs
leads
Lower respiratory tract
Lung fibrosis
MCODE score
mechanism
molecular mechanism
NFkB1
NHBE
Organ failure
pandemic
pathway
Pathways
Patient
potential mechanism
POU2F2
pro-inflammatory cytokine
pro-inflammatory cytokines
protein-protein interaction
receptor
reducing
referred to
Regulation
regulatory network
respiratory
Result
resulting
RNA sequencing
robust antiviral response
SARS-CoV-2
SARS-COV-2 infection
severe COVID-19
severe COVID-19 patients
severe pneumonia
Signaling
signaling pathway
STAT
Stat1
STAT2
STAT3
storm
suggested
Suppressing
Systems biology
the cells
the cytokine storm
TNF
transcription factor
transcription factors
Transcriptome
Tuberculosis
up-regulated
Viral
viral infection
Vitamin
Vitamin D
were used
[DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology