Targeting of the CD80/86 proinflammatory axis as a therapeutic strategy to prevent severe COVID-19심각한 CovID-19를 예방하기위한 치료 전략으로서 CD80/86 전 염증 축의 표적화Article Published on 2021-06-012022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 임상, 진단, 치료법, 치료제, [키워드] abatacept analyzed antagonistic block Blood blood sample Blood samples Bronchoalveolar lavage fluid CD80 change China Cohort controls COVD-19 patients COVID-19 COVID-19 case COVID-19 severity COVID19 cytokine Cytokine storm drug effective elicited epicenter epidemiological Evidence excessive immune response exploratory functional hallmark hyperinflammation immunological Inflammatory diseases Mild pandemic patient cohorts patients treated Prevent proinflammatory PROTECT regulated RNA-Seq SARS-COV-2 infection severe COVID-19 severe COVID-19 patient Signaling significantly single-cell RNA-seq Stimulation Support systemic level Target identification targeting Therapeutic approach therapeutic strategy Treatment USA viral infection [DOI] 10.1038/s41598-021-90797-0 PMC 바로가기 [Article Type] Article
Olfactory Training and Visual Stimulation Assisted by a Web Application for Patients With Persistent Olfactory Dysfunction After SARS-CoV-2 Infection: Observational StudyObservational Study Published on 2021-05-272022-10-04 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] Analysis Anosmia app application baseline benefit cohort of patient COVID-19 defined dysfunction faster Hyposmia IMPROVE improvement increase in less nose objective Observational olfactory olfactory dysfunction olfactory training participant Patient patients performed persistent Primary outcome Quantitative data real-life study Result SARS-CoV-2 SARS-COV-2 infection senses Smell Stimulation training Visual Visual Analogue Scale was performed Web web application, eHealth [DOI] 10.2196/29583 PMC 바로가기 [Article Type] Observational Study
Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age풍토성 코로나바이러스에 의해 유도된 순환하는 CD4 T 세포는 항원 특이성 및 연령과 관련된 풍부함 및 기능적 잠재력에 있어 큰 격차를 나타냅니다.Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age CD4 CD4 T cell CD4 T cells Cell Cell-mediated immunity circulating collected comparable coronavirus cross-reactive disparity display endemic human coronavirus endemic human coronaviruses epitope Epitopes evaluated examined functional granzyme granzyme B HCoV Infection Influenza interferon interferon-γ interleukin interleukin-2 lack long-lasting memory cell Memory cells nucleocapsid Potential protective immunity reactivity recruited recruitment response robust SARS-CoV infection SARS-CoV infections SARS-CoV-2 SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus specificity Spike proteins Stimulation subject subjects T cells thought Vaccinations Viral antigen [DOI] 10.1093/infdis/jiab076 PMC 바로가기 [Article Type] Article
Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle?Observational Study Published on 2021-05-132022-10-04 Journal: Reproductive Biology and Endocrinology : RB&E [Category] SARS, 임상, [키워드] Characteristics COVID-19 embryo quality Follow-up Future information IVF mRNA not affect objective outcome measure ovarian Ovarian stimulation Patient reached receiving Result SARS-CoV-2 vaccination SARS-CoV-2 vaccine setting Stimulation subsequent Treatment vaccination variable variables were assessed [DOI] 10.1186/s12958-021-00757-6 PMC 바로가기 [Article Type] Observational Study
Impact of COVID-19 on a Pragmatic, Cluster Randomized Clinical Trial for FibromyalgiaConference abstract Published on 2021-05-012022-10-05 Journal: The Journal of Pain [Category] 임상, [키워드] addition Analysis assessment clinical clinical trial clinics COVID-19 COVID-19 pandemic enrolled Enrollment facilitate fibromyalgia FIVE greater Healthcare system Healthcare systems Impact impacted IMPROVE in-person visit include interactions nerve NIH Pain pandemic Patient patients Personal protective equipment Pragmatic Primary outcome PROTECT question questionnaire data reduced significantly social distancing statistical Stimulation Study design the patient Transcutaneous transitioned Trial Volume [DOI] 10.1016/j.jpain.2021.03.037 [Article Type] Conference abstract
IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammationIFN-γ 및 TNF-α는 심각한 COVID-19 폐 및 조직 염증이 있는 염증성 질환에서 확장된 CXCL10+ CCL2+ 대식세포 표현형을 유도합니다Research Published on 2021-04-202022-08-13 Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] affected anti-cytokine antiviral interferon approach Arthritis association bronchoalveolar lavage samples CCL2 CCL3 CD ileum Cell cell-type identification cellular phenotype cellular phenotypes Combination COVID-19 Crohn’s disease CXCL10 CXCL9 Cytokines defined disease-affected donor disease-affected donors disparate Donor driving Effect elevated environmental factor environmental factors established therapy exhibited FIVE GBP1 Genes healthy healthy control healthy subject healthy subjects help human blood-derived macrophage human blood-derived macrophages identify IFN-beta IFN-beta (IFN-β IFN-gamma IFN-β IFN-γ IL1B Immune cell immune cell state immune cell states immune state Immunomodulatory therapies inflamed CD ileum inflamed RA synovium inflamed tissue inflamed tissues Inflammatory inflammatory disease Inflammatory diseases inflammatory factors inflammatory macrophage phenotype Integrative analysis interferon response interferons Interstitial lung disease lung Lung disease lupus erythematosus Macrophage Macrophage heterogeneity macrophage phenotype macrophage phenotypes macrophage state Macrophage stimulation macrophages Meta-analysis mixed-effects modeling Patient patients with COVID-19 pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines protective effect RA synovium Result rheumatoid arthritis severe COVID-19 severe COVID-19-affected lungs single-cell Single-cell multi-disease tissue integration single-cell profile Single-cell transcriptomics SLE Stat1 stimulated Stimulation Support systemic lupus erythematosus tested These cells tissue tissue inflammation tissues TNF TNF-α transcriptomic profile Treatment UC colon ulcerative colitis understanding [DOI] 10.1186/s13073-021-00881-3 PMC 바로가기 [Article Type] Research
Successful Spinal Cord Stimulation for Necrotizing Raynaud’s Phenomenon in COVID-19 Affected Patient: The Nightmare Comes BackAnesthesiology Published on 2021-04-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Anxiety back characterized condition CORD coronavirus COVID-19 distal effective endotheliopathy Evidence initial Interaction Ischemia Necrosis oxygen Pain patients peripheral ischemia peripheral tissues phenomenon Potential treatment raynaud phenomenon recent reducing reported SARS-CoV-2 SARS-COV-2 infection SCS selected spinal spinal cord stimulation Stimulation Stress Symptom syndrome systemic inflammatory temperature thrombotic event treated Treatment triggered Vascular vascular disease vascular pain vessels [DOI] 10.7759/cureus.14569 PMC 바로가기 [Article Type] Anesthesiology
Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by DexamethasoneOriginal Article Published on 2021-04-162022-10-30 Journal: Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced [DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article
Deep Brain Stimulation for Parkinson’s Disease During the COVID-19 Pandemic: Patient PerspectiveNeuroscience Published on 2021-04-012022-10-31 Journal: PeerJ [Category] COVID-19, [키워드] activity Administered Brain Care changed consecutive patient coronavirus COVID-19 COVID-19 pandemic daily living deep deep brain stimulation Elective surgery Government Health health care systems hospital hospitals impacted majority MOST outbreak pandemic Parkinson’s disease Parkinson’s disease Patient Person-centered care Prevent preventive measure Public public health questionnaire Region Regulation Result routine Ruijin seeking Shanghai Stimulation Symptom the patient virus spread [DOI] 10.3389/fnhum.2021.628105 PMC 바로가기 [Article Type] Neuroscience
DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in miceSARS-CoV-2 스파이크 단백질을 인코딩하는 DNA 백신 후보는 마우스에서 강력한 체액성 및 Th1 세포 매개 면역 반응을 유발했습니다Research Article Published on 2021-03-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS, [키워드] ACE2 Antigen balance binding breadth candidate cell-mediated immune response COVID-19 Critical died DNA vaccine DNA vaccines Effective vaccines elicited expressing followed by full length full-length S geometric mean geometric mean titer geometric mean titers GMTs highest humoral IFN-γ IgG IgG1 IgG2a infection with SARS-CoV-2 inhibit Interaction limit lowest magnitude mice neutralizing antibody pandemic peptide positive cell positive cells PRNT50 PRNT50 titers Protein robust SARS-CoV-2 spike SARS-CoV-2 spike peptide SARS-CoV-2 spike protein sera splenocyte splenocytes Stimulation T cell T cell responses T cells Th1 Vaccine Viral viral RBD wild type [DOI] 10.1371/journal.pone.0248007 PMC 바로가기 [Article Type] Research Article