Development of a COVID-19 Web Information Transmission Structure Based on a Quadruple Helix Model: Webometric Network Approach Using BingOriginal Paper Published on 2021-08-262022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed Asia big data caused change changed communication content analysis COVID-19 COVID-19 pandemic determine Developing development domain early stages effective events Evolution Government Health helix indicated infodemiology information infoveillance initial Internet less limitation network network analysis Nonprofit organization objective online health information organization organizations pandemic produced public health public health emergency quadruple helix model Region Research respond Result Spread stages Structural analysis Structure Topic Transmission virus virus spread Web webometrics [DOI] 10.2196/27681 PMC 바로가기 [Article Type] Original Paper
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporterArticle Published on 2021-08-202022-10-04 Journal: Nature Communications [Category] 변종, [키워드] bind binding binding pocket binding site Characteristics characterization characterized concentrations cryo-EM Cryoelectron microscopy depressive disorder exhibit Extracellular impede information inhibitor interacting residue Ligand Mental Molecular dynamics simulation molecular interaction molecular pharmacology Mutagenesis nanomolar affinity observé Pharmacodynamics Protein structure predictions resulting reveal selective Serotonin serotonin reuptake inhibitor Structural analysis structural biology target therapeutic Transport Transporters in the nervous system Treatment unique Vilazodone [DOI] 10.1038/s41467-021-25363-3 PMC 바로가기 [Article Type] Article
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis몰누피라비르 유발 SARS-CoV-2 돌연변이 유발 메커니즘Article Published on 2021-08-112022-09-10 Journal: Nature Structural & Molecular Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] (RdRp (RdRp) active form Analysis animal model animal models antiviral activity antiviral drug base pair base pairs biochemical assay cause complexes COVID-19 Cryo-EM analysis Cryoelectron microscopy cytidine cytidine triphosphate explain Frequency High-resolution humans impair incorporation increase mechanism molecular mechanism molecular mechanisms molnupiravir Mutagenesis mutated Mutation NHC patients with COVID-19 phase III trial Phase III trials polymerase Proofreading RdRP resulting RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 mutagenesis SARS-CoV-2 replication Structural analysis substrate Template Treatment triphosphate uridine uridine triphosphate Viral Viral mutagenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41594-021-00651-0 PMC 바로가기 [Article Type] Article
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 proteaseTheobroma cacao L. 화합물: 주요 SARS-CoV-2 프로테아제 억제제로서의 이론적 연구 및 분자 모델링Article Published on 2021-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료제, [키워드] acute respiratory syndrome alanyl antioxidant binding binding efficiency Bioflavonoids carbonyl cause chemical property Cocoa bean complex Compound coronavirus COVID-19 DFT enzyme evaluated free energy Free energy calculation Free energy calculations high affinity in silico in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 Ligand molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations naringin performed presenting protease Quantum mechanics rutin SARS-CoV-2 SARS-CoV-2 protease Severe acute respiratory syndrome starting point Structural analysis Theobroma cacao Theobroma cacao. [DOI] 10.1016/j.biopha.2021.111764 PMC 바로가기 [Article Type] Article
Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19FDA 승인 약물로부터 SARS-COV-2 엔도 리보 뉴 클레아 제 (ENDOU)의 잠재적 억제제의 확인 : COVID-19에 대한 치료제를 찾기위한 약물 재구성 접근법Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site Amino acid amino acid residues antiviral drug approach approved binding binding affinity binding free energies binding free energy calculated catalytically causative agent Clinical efficacy Comparative Compound COVID-19 diabete diabetes dose drug Drug development Drug repurposing ENCODE endonuclease EndoU enzyme essential amino acid FDA free energies Glisoxepide IC50 Idarubicin identification in silico inhibitor intermolecular interaction leukemia life cycle molecular molecular dynamic simulation molecular dynamics monophosphate Nsp15 performed predicted required responsible ribonucleotide SARS-CoV-2 selected Simulation study Structural analysis suggested surface area therapeutic therapeutic option treat Treatment uridine uridine monophosphate Vaccine Viral Virtual screening Virus life cycle [DOI] 10.1080/07391102.2020.1775127 PMC 바로가기 [Article Type] Article
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased TransmissibilitySARS-CoV-2 스파이크/인간 ACE2 복합 인터페이스의 구조 모델링은 전파율 증가와 관련된 고친화도 변이를 식별할 수 있습니다.Article Published on 2021-07-232022-09-11 Journal: Journal of Molecular Biology [Category] SARS, 변종, [키워드] ACE2 affinity Analysis antibody antibody resistance Applying binding binding affinities binding affinity changes in circulating Cluster Combination combinatorial mutations complex complexes COVID-19 pandemic determine E484K Effect flexible functional G476S generate hACE2 help human ACE2 human ACE2 receptor Increased Infection Interaction interface Intervention K31 K353 modeling mutant Mutation N501Y pathogenic Point mutation predict predicted Protein Protein binding public health measure Region reveal S477N SARS-CoV-2 SARS-CoV-2 spike protein screening method sequence spike spike mutations Spike protein Structural analysis structural modeling susceptibility susceptibility to infection the SARS-CoV-2 Transmissibility transmissible variants transmissible variants. triggered variant variants Variation viral strains viral variant wild-type [DOI] 10.1016/j.jmb.2021.167051 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, IndiaArticle Published on 2021-07-202022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 binding acute respiratory syndrome Affect Against Analysis approach B.1.617.1 B.1.617.2 binding change circulating cleavage Continuous coronavirus country COVID-19 D614G Epidemiology Evolution furin cleavage site genomic help identify India indicated L452R Lineage lineages mAbs Maharashtra modeling monoclonal antibody Mutant strains Mutation neutralization P681R pandemic phenotypic RBD RBD mutation RBD mutations reported residue responsible resulting SARS-CoV-2 second second wave sequence Sequencing spike Spike protein strain Strains Structural analysis T478K the receptor-binding domain the spike protein Transmissibility Transmission variant VoC VOCs Wave whole genome whole genomes [DOI] 10.3390/microorganisms9071542 PMC 바로가기 [Article Type] Article
Under the COVID-19 Environment, Will Tourism Decision Making, Environmental Risks, and Epidemic Prevention Attitudes Affect the People’s Firm Belief in Participating in Leisure Tourism Activities?Article Published on 2021-07-162022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Attitude belief conducted COVID-19 Dajia Matsu pilgrimage Decision making Environment Epidemic epidemic prevention attitude Intention leisure mental health participant physical prevention questionnaire risk Risk perception significantly SPSS 26.0 statistical Structural analysis Tourism tourism decision making Travel was used [DOI] 10.3390/ijerph18147539 PMC 바로가기 [Article Type] Article
Sequence and structural analysis of COVID-19 E and M proteins with MERS virus E and M proteins—A comparative studyResearch article Published on 2021-07-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 변종, [키워드] analyzed bat beta coronavirus Beta coronaviruses binding C-terminal domain catalytic caused conserved COVID-19 Critical demonstrated E protein envelope highlight humans Infection inhibitor Interaction lethal infection M protein MERS MERS virus motif occurred outbreak pandemic Phosphorylation Protein Proteins Region regions Research SARS virus sequence Sequence analysis sequence and structural analysis Serine serine proteases similarity Structural analysis the Spike Variation variations virus viruses [DOI] 10.1016/j.bbrep.2021.101023 [Article Type] Research article
Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1Article Published on 2021-06-082022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] addition C-terminal caused Cell complex COVID-19 pandemic Cryo-electron microscopy cryo-EM Cryoelectron microscopy determine domain E protein envelope protein facilitate Health human cell human protein human proteins hydrophobic residue inhibitor Interaction junctions lung epithelial motif observation occur PALS1 peptide promote Protein provide recognize recruit reduce Replication reported SARS-CoV-2 SARS-CoV-2 envelope SARS-CoV-2 viral SARS-CoV-2 virus Spread Structural analysis target targets the SARS-CoV-2 virus Viral protein viral-host protein virulence Virus structures Virus-host interactions [DOI] 10.1038/s41467-021-23533-x PMC 바로가기 [Article Type] Article