Quantifying impacts of the COVID-19 pandemic through life-expectancy losses: a population-level study of 29 countriesCovid-19 Published on 2022-02-262022-10-30 Journal: International Journal of Epidemiology [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] age calculated comparable comparison contributed country COVID-19 COVID-19 pandemic cumulative mortality deaths declined demography Europe European examined females group Impact increased mortality increases in Life expectancy Life table Lithuania magnitude male Mortality pandemic provide reduction reductions in Result Sex Soviet Union structures triggered USA World War II [DOI] 10.1093/ije/dyab207 PMC 바로가기 [Article Type] Covid-19
Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand InteractionsArticle Published on 2022-02-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 3CL accumulating acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays binding energy breakthrough infections catalytic dyad cellular conserved coronavirus coronavirus disease covalent inhibitor drug candidate drug design dyad Efficacy effort etiological agent examined exhibited FIVE High-resolution histidine inhibitor inhibitors inhibitory Medicines molecular dynamics simulations molecule design Pro protease residue SARS-CoV-2 significantly structures Vaccine development Viral load viral replications [DOI] 10.3390/ijms23042392 PMC 바로가기 [Article Type] Article
The Physical Basis for pH Sensitivity in Biomolecular Structure and Function, With Application to the Spike Protein of SARS-CoV-2Molecular Biosciences Published on 2022-02-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acquisition application Basis benefit bioinformatics calculate conformation conformational changes Coronaviruses demonstrated effort experimental structure form function functional histidine increasingly Interaction mitigate modulation molecular Molecular dynamics simulation Neutral omicron pH dependence physical predict Protein protein electrostatics question SARS-CoV-2 sensitivity solvent Spike protein Stage Structure structures the Spike the spike protein variant spike variants Variation [DOI] 10.3389/fmolb.2022.834011 PMC 바로가기 [Article Type] Molecular Biosciences
Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants신종 SARS-CoV-2 변이체의 스파이크 단백질 구조 및 항원 변이Review Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus antibody Antibody binding Antibody therapeutics Antibody-mediated neutralization antigenic variation complex component conjunction coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical epitope escape mutation facilitate functional fusion host cell immune immune evasion mapped Mutation mutations NAb NAbs neutralization Neutralizing antibodies neutralizing antibody potency predict recent respiratory SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Structure structures the RBD the spike protein therapeutic therapeutic antibodies therapy Vaccine Vaccines virus virus entry [DOI] 10.1371/journal.ppat.1010260 PMC 바로가기 [Article Type] Review
Individual risk perception and empirical social structures shape the dynamics of infectious disease outbreaksResearch Article Published on 2022-02-162022-10-28 Journal: PLoS Computational Biology [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] absence accelerate addressed Affect affected change characterized Community Compliance Contact develop diffusion disease disease risk Effectiveness Epidemic epidemiological evaluate facial feature fixed fraction Government heterogeneity highlight Hospitalization Hospitalized individual individual level individuals infectious disease outbreak interaction pattern Mask mathematical Measures modulate outbreak performed risk Risk perception significantly social contact social distancing Spread Structure structures the disease the epidemic total population [DOI] 10.1371/journal.pcbi.1009760 PMC 바로가기 [Article Type] Research Article
An In Vivo Observational Histological Study of Peripheral Arterial Damage in Patients with Acute Limb Ischemia in SARS-CoV-2 InfectionArticle Published on 2022-02-142022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] active smokers Acute limb ischemia Analysis analyzed arterial Arterial hypertension CD45 CD68 change damage Diabetes Mellitus endothelial Endothelial dysfunction events Evidence histologic histological histopathological immunohistochemistry in vivo Inflammation intraarterial investigated Ischemia lack limb mechanism obese Patient patients patients with COVID-19 performed peripheral prothrombotic Reactions reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients skeletal muscles structures suffered Thrombus thrombus formation tissue [DOI] 10.3390/diagnostics12020488 PMC 바로가기 [Article Type] Article
Innovation Centers in Health Care Delivery Systems: Structures for SuccessViewpoint Published on 2022-02-102022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] accelerated activities approach build Care center COVID-19 pandemic creating delivery delivery science Digital health example experience form generate Health health care delivery Health Service health system highlight identify implementation IMPROVE Innovation National outcome pandemic Patient process improvement Quality improvement reduce costs reducing reform Strategy Structure structures success Support survey value value-based care Virtual care while [DOI] 10.2196/33961 PMC 바로가기 [Article Type] Viewpoint
Digitally enabled supply chain as a strategic asset for the COVID-19 response in AlbertaOriginal Articles Published on 2022-02-102022-10-31 Journal: Healthcare Management Forum [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] approach conducted COVID-19 demonstrated healthcare implementation include management National opportunity overcome pandemic public health Research responses Seven structures unique [DOI] 10.1177/08404704211057525 PMC 바로가기 [Article Type] Original Articles
SARS-CoV-2: The Monster Causes COVID-19SARS-CoV-2: 괴물이 COVID-19를 유발합니다Review Published on 2022-02-082022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] addition analyzed animals cats cause Characteristics Clinical characteristics coronavirus COVID-19 Diagnosis Evolution Human human coronavirus humans Impact infect Monster pandemic Particle pathogenic mechanisms prevention prevention of COVID-19 problem problems SARS-CoV-2 structures therapy Transmission Treatment Variation virus viruses [DOI] 10.3389/fcimb.2022.835750 PMC 바로가기 [Article Type] Review
Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2Article Published on 2022-02-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 6M0J ACE2 receptor Action analogue antimalarial Antiviral binding affinity biological activity carcinogenicity compounds COVID-19 database evaluated FIVE identification identify in vitro in vivo inhibitor Interaction intestinal investigated investigation mechanism of action molecular molecular docking molecular docking studies MPro PDB penetration pharmacokinetic Potential protease inhibitors receptor Receptor-binding domain risk SARS-CoV-2 selected Structure structures Virtual screening was performed was used were used [DOI] 10.3390/ijms23031781 PMC 바로가기 [Article Type] Article