RIC in COVID-19—a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19Original Article Published on 2021-06-252022-10-31 Journal: Cardiovascular Drugs and Therapy [Category] COVID-19, COVID19(2023년), MERS, SARS, 변종, [키워드] acute respiratory distress acute respiratory syndrome Administered Admission ARDS Blood blood pressure Brazil Can caused clinical clinical trial Conditioning coronavirus coronavirus disease 19 COVID-19 Critical cytokine Cytokine storm Cytokines cytotoxicity death diagnosed dysregulated Elevation endothelial cells enrolled Evidence Immunosuppression in vitro Inflammatory cytokine inflammatory cytokine production Inflammatory response initial intensive care involved Ischemic multi-organ failure Non-invasive occur outcomes Patient pilot study Primary outcome randomized clinical trial Registered Registration remote remote ischemic conditioning SARS-CoV-2 SARS-COV-2 infection secondary endpoint South Africa suppress suppresse Suppressing syndrome the cytokine storm United Kingdom variants of concern with COVID-19 [DOI] 10.1007/s10557-021-07221-y PMC 바로가기 [Article Type] Original Article
Clinical Presentations and Outcomes of Coronavirus Disease 2019 in Patients With Solid TumorsInternal Medicine Published on 2021-06-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 30-day mortality rate affected age Breast cancer Cancer cancer patient Cancer patients Care Chinese clinical clinical presentation Colorectal cancer Comorbidity conducted contracting the virus Coronavirus disease 2019 correlated COVID-19 COVID-19 in patient COVID-19 patient decrease demographic characteristics Diabetic diagnosed Diagnosis Factors General population Health Hospitalized immune individual intensive care Laboratory Leukocytosis lung cancer lymphocytopenia male Mortality mortality rate Older age outcomes pandemic Patient patients patients died polymerase chain populations presentation Prostate Prostate cancer Result Science second set Solid solid tumor solid tumors study population suppresse the median the patient therapy therapy for COVID-19 Tumor university [DOI] 10.7759/cureus.15452 PMC 바로가기 [Article Type] Internal Medicine
Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progressionMaackia amurensis seed lectin(MASL)이 SARS-CoV-2 감염 및 COVID-19 질병 진행을 억제할 가능성이 있는 구강 편평 세포에 다면발현 작용을 한다는 증거Article Published on 2021-06-012022-09-11 Journal: Experimental cell research [Category] SARS, 치료제, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 proteins ACE2 receptor addition agent Antiviral antiviral agent ARDS bind binding can be used caused Cell confirmed COVID-19 case COVID-19 COVID-19 disease COVID-19 patients Culture death decrease epithelial cell epithelial cells Express expression glycosylated glycosylation host cells identify infect infect cell Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inhibit inhibit SARS-CoV-2 international public health kidney lectin Maackia amurensis Modification oral oral mucosa Oral squamous cells pandemic pleiotropic progression Protein respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sialic acid Spike protein squamous suppresse target the SARS-CoV-2 the SARS-CoV-2 virus viral-host interaction [DOI] 10.1016/j.yexcr.2021.112594 PMC 바로가기 [Article Type] Article
Immunological Aspects of SARS-CoV-2 Infection and the Putative Beneficial Role of Vitamin-DReview Published on 2021-05-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression activating Activation acute respiratory syndrome adaptive Adaptive immunity Alveolar Type II amplification angiotensin-converting enzyme 2 antibody Antigen antimicrobial peptide aspect attenuate autophagy B cells Bioavailability caused CD4 Cell cells circulating combating complex Concentration coronavirus Coronavirus disease 2019 Coronavirus-2 correlated COVID-19 criteria cytokine release Cytokine storm Cytokine storms defend Degradation determine dosage Effectiveness ENhance enzyme epithelial cell Evidence expression Future Health immune response Immunity incidence increase individuals with COVID-19 infect Inflammation inhibit inhibiting Innate immunity Interaction Local lysosomal macrophages mechanism meet Multiple nuclear observation Organ failure Particle Population pro-inflammatory cytokine progression promote RAS receptors renin–angiotensin–aldosterone system required responsible role SARS-CoV-2 SARS-CoV-2 viral particles secretion serum severe acute respiratory syndrome coronavirus 2 severity of COVID-19 shown Signaling Spike protein suppresse T cell T cells T helper tissue Toll-like receptor virus Vitamin D Vitamin D supplementation [DOI] 10.3390/ijms22105251 PMC 바로가기 [Article Type] Review
The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical ApplicationPharmacology Published on 2021-05-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Actin Activation addressed allergenic anti-infammatory Anti-inflammatory anti-inflammatory agent anti-inflammatory effect Anti-viral anti-viral drug anti-viral effect antibody secretion Apoptosis appear application applied attenuate autophagy B-cell bird nest cellular Chinese traditional medicine clinical contaminant coronavirus COVID-19 cytokine cytokine secretion Defense Degradation derivative disease droplets drug edible bird’s nest Efficacy endosomal trafficking ENhance exacerbated Health highlighting host cells immunomodulatory effects IMPROVE in vitro in vivo models infected cells infections Influenza influenza A influenza infection lysosomal Nest Novel coronavirus oxidative pandemic Pathogenesis Pathogens Patient patients Potential pro-inflammatory cytokines proliferation property protective effect reduce replicated reported respiratory viral infections secretion severe symptom sialic acid suppresse therapeutic therapeutic effects transmitted treat Vaccine viral replication virus [DOI] 10.3389/fphar.2021.633292 PMC 바로가기 [Article Type] Pharmacology
Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells플루티카손 프로피오네이트는 1차 인간 비강 상피 세포에서 폴리(I:C) 유도 ACE2를 억제합니다Cellular and Infection Microbiology Published on 2021-04-262022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술, [키워드] ACE2 ACE2 expression ACE2 protein Activation Affect affected agonist analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry collected Corticosteroid COVID-19 dissemination enzyme epithelial cells evaluate examined expression expression of gene fluticasone fluticasone propionate Fold change followed by Gene Expression Health health problem HNECs host cells Human immunoblot immunofluorescence incubated Incubation individuals Infection initial innate immune interferon intranasal intranasal steroid spray investigated mRNA expression nasal Nasal cavity nasal epithelial cell nasal mucosa NFκB objective poly(I:C poly(I:C) promote propionate protease Protein quantitative PCR receptor regulated required reservoir Result SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral SARS-CoV2 Serine serine 2 significantly increased Spread steroid suppresse suppressed thought TLR TLR agonists TLR3 TMPRSS2 Toll-like receptors transmembrane transmembrane protease serine 2 Viral virus infection [DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
The Impact of Individual Behaviors and Governmental Guidance Measures on Pandemic-Triggered Public Sentiment Based on System Dynamics and Cross-ValidationArticle Published on 2021-04-162022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] Behavior change China contribute COVID-19 COVID-19 epidemic Cross-validation dissemination Dynamics Effect Effectiveness Epidemic Evolution Government Guidance Impact increase in individual introduced measure Measures negative negative emotion pandemic Pandemics Panic positive positive emotions promote Public public sentiment Regulation simulation and control Spread suppresse System system dynamics widespread [DOI] 10.3390/ijerph18084245 PMC 바로가기 [Article Type] Article
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies전신 중화 항체 치료 후 비갑개에서 강력한 SARS-CoV-2 감염Article Published on 2021-04-142022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Angiotensin converting enzyme-2 antibody binding characterized competing coronavirus COVID-19 determine DNA hamster human neutralizing antibody implication Infection inhibit SARS-CoV-2 injection Injury intranasal intranasally live SARS-CoV-2 lung lung damage Lung injury nasal nasal turbinate Neutralizing neutralizing antibody phage display RBD Receptor binding Receptor binding domain reduce Reinfection robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly suppresse tested therapy Transmissibility treated Treatment upper respiratory upper respiratory tract vaccination Vaccine viral infection Viral load [DOI] 10.1016/j.chom.2021.02.019 PMC 바로가기 [Article Type] Article
SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3Research Paper Published on 2021-04-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] 3C-like protease acute respiratory syndrome antiviral agent cells circulating coronavirus cytoplasm downstream expression highly pathogenic human coronaviruses IFN IFN antagonists IFN-β implication Infection IRF3 MAVS mechanism nsp5 nuclear translocation outcome phosphorylated Phosphorylation protease Protein reported retained RIG-I SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease strain suggested suppresse suppression TBK1 Transcription type I interferon type I interferons variant [DOI] 10.7150/ijbs.59943 PMC 바로가기 [Article Type] Research Paper
Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase클래스 III 포스포이노시티드 3-키나아제를 표적으로 하여 생체 외 인간 폐 조직에서 SARS-CoV-2 감염 억제Article Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral effect approved ATG14 autophagolysosome autophagy Betacoronavirus canonical caused cellular class III PI3-K clinically complex component coronavirus coronavirus disease COVID-19 COVID-19 treatment Ex vivo ex vivo human lung tissues. examined Factor HCQ Host human lung human lung tissue Immunosuppression include Infection inhibit inhibited inhibiting inhibitor involved kinase Kinase inhibitor lysosomal novel Betacoronavirus pandemic pathway Prevent Previous studies previous study SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules suggested suppresse suppressed suppression tested therapeutic therapeutic target therapeutic targets tissues Transmissibility Treatment Ulk1 Vps34 [DOI] 10.1002/jmv.26583 PMC 바로가기 [Article Type] Article