Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues비만 및 케톤 생성 식단은 쥐의 폐와 심장 조직에서 SARS-CoV-2 진입 단백질 ACE2 및 TMPRSS2와 레닌-안지오텐신 시스템을 뚜렷하게 조절합니다Article Published on 2021-09-252022-09-10 Journal: Nutrients [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Affect Alter angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-inflammatory effect attenuate components diet elevated enzyme Gene Expression heart hearts IL6 increase individuals Inflammation inflammatory gene inflammatory genes interleukin-6 interleukin-6 receptor ketogenic Ketogenic diet Ketogenic Diets ketones lung lung tissues Lungs MasR mechanism Migration obese obesity obesogenic outcomes protease Protein RAS RAT Renin renin-angiotensin system SARS-CoV-2 SARS-CoV-2 entry Serine serine 2 severity Severity of infection sucrose System tested the SARS-CoV-2 tissues TLR4 TMPRSS2 TMPRSS2 level TMPRSS2 levels TNF-alpha Toll-like receptor toll-like receptor 4 transmembrane transmembrane protease serine 2 Viral viral entry were measured [DOI] 10.3390/nu13103357 PMC 바로가기 [Article Type] Article
Competing Bioaerosols May Influence the Seasonality of Influenza-Like Illnesses, including COVID-19. The Chicago ExperienceArticle Published on 2021-09-162022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] bioaerosol Bioaerosols Chicago competing COVID-19 experience Factor fibrin(ogen) D-domain flu influence influenza-like illness (ILI) influenza-like illnesses Innate immunity mold spores pollens receptor SARS-CoV-2 seasonality spores TLR4 Toll-like receptor virus [DOI] 10.3390/pathogens10091204 PMC 바로가기 [Article Type] Article
Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar MacrophagesArticle Published on 2021-09-022022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] ACE-2 Activation activities Alpha alveolar macrophage analyzed angiotensin-converting enzyme-2 Anti-inflammatory anti-inflammatory property caused COVID-19 COVID19 COX2 cytokine demonstrated downregulation downstream IL-1β IL-6 immunomodulatory activity increase in inflammatory pathway Inflammatory response inhibit involved MAPK marker mechanism of action MOST murine murine alveolar macrophages NF-κB nitric oxide NLRP3 nuclear palmitoylethanolamide pathway primary culture proinflammatory receptor receptors reduced response SARS-CoV-2 SARS-CoV-2 spike glycoprotein selective several gene spike Spike protein tested therapeutic potential TLR4 TNF-α um-PEA upregulation [DOI] 10.3390/metabo11090592 PMC 바로가기 [Article Type] Article
Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin국소 차아염소산(HOCl)은 UV에 노출된 SKH-1 고위험 마우스 피부에서 염증성 유전자 발현 및 종양 발생 진행을 차단합니다Article Published on 2021-09-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, [키워드] addition Analysis AP-1 atopic dermatitis bioluminescent block blocked Cancer Carcinogenesis clinical evidence combinations condition consequence COVID-19 pandemic drinking water elicited environmental exposure example exposure to finding Gene Expression Gene expression analysis high risk HMOX1 HOCl hypochlorous acid Il19 Immunohistochemical analysis Inflammation Inflammatory inflammatory signaling investigated luciferase mice mimicking modulation molecular murine model NOS2 observation oxidative stress oxidizing Pathway-focused gene expression profiling performed progression psoriasis PTGS2 public health Radiation reconstructed released skin skin cancer Solar Solar UV radiation. Srxn1 Stress stress response subsequent Support suppressed suppression Swimming pool therapeutic therapeutic intervention These data TLR4 Topic topical transgenic ultraviolet water [DOI] 10.1016/j.redox.2021.102042 PMC 바로가기 [Article Type] Article
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
S100A8 may govern hyper-inflammation in severe COVID-19S100A8은 심각한 COVID-19에서 과염증을 지배할 수 있습니다.Article Published on 2021-09-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 변종, 진단, 치료제, [키워드] accumulating Activation acute respiratory distress acute respiratory distress syndrome affected ARDS Biomarker calcium calcium-binding protein cells chronic myeloid leukemia clinical information Coagulation coagulation cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-associated ARDS disease disease severity effective Elimination endotoxin Evidence extrinsic form herd immunity homeostatic hyper-inflammation Hypothesis Immunity include increased vascular permeability Inflammation Interaction leukemia Ligand lung molecular target mortality rate myeloid cells myeloid-derived suppressor cells overcome pandemic Pathogens predict reagent receptor recruitment respiratory distress Respiratory distress syndrome S100A8 S100A9 severe COVID-19 severe forms of COVID-19 similarity situation syndrome TLR4 to define Toll-like receptor Treatment upregulated upregulation Vaccine vascular permeability [DOI] 10.1096/fj.202101013 PMC 바로가기 [Article Type] Article
Crosstalk of TLR4, vascular NADPH oxidase, and COVID-19 in diabetes: What are the potential implications?Review article Published on 2021-08-012022-10-05 Journal: Vascular pharmacology [Category] SARS, 변종, [키워드] appear cardiovascular diseases contribute COVID-19 Critical Crosstalk diabetes Diabetic diabetic patients disrupt enzyme experimental evidence explain help higher risk Hypothesis implication Increased Interaction lack likelihood mechanism modulate NADPH NADPH oxidase oxidative stress pathophysiology patients with diabete progression receptor ROS severe coronavirus disease severe COVID-19 shown Signaling structures TLR4 Vascular vasculature [DOI] 10.1016/j.vph.2021.106879 [Article Type] Review article
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in PathogenesisSARS-CoV-2에 감염된 소아 대뇌 피질 뉴런: 전사체 분석 및 병인에서 유료 유사 수용체의 잠재적 역할Article Published on 2021-07-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] ACE2 caspase caspase 8 cells cerebral changes in chemokine chemokines children cortical COVID-19 neurological symptom COVID-19 neurological symptoms deregulation downregulated downregulation downstream ERK expression genes encoding human neuronal cells IKKε increase in increased expression infect infected with SARS-CoV-2 IRF3 JNK mechanism medium nervous system Neurological involvement Neurological symptoms Neuron neuronal next generation sequencing NF-κB Nod-like receptors not express Pathogenesis Pattern recognition pattern recognition receptor pediatric Potential receptor receptors replicate responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins scavenger receptors Sequencing Signaling TLR TLR1 TLR4 TLR6 TLRs TMPRSS2 Toll-like receptor Toll-like receptors TRAF3 transcriptomic analysis transcriptomic profile upregulated upregulation Viral Viral RNA western blot [DOI] 10.3390/ijms22158059 PMC 바로가기 [Article Type] Article
Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patientsArticle Published on 2021-07-272022-10-04 Journal: Scientific Reports [Category] 치료기술, [키워드] Admission Biomarkers control group correlated COVID-19 cytokine Cytokines Deceased domain enrolled expression Gene Expression IL-18 Infection Innate immunity interferon Lower lower expression mechanical ventilation mRNA outcome overexpression Patient pattern Peripheral blood peripheral blood cell plasma receptor Recognition respiratory severe COVID-19 severe COVID-19 patient supplementary oxygen survived TLR3 TLR4 TLRs Toll-like receptor Toll-like receptor 3 was determined World Health Organization [DOI] 10.1038/s41598-021-94624-4 PMC 바로가기 [Article Type] Article
Potential Implications of a Type 1 Interferon Gene Signature on COVID-19 Severity and Chronic Inflammation in Sickle Cell DiseaseMedicine Published on 2021-07-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] adaptive airway Anti-viral anti-viral response B cell baseline bind Cell cell death chronic clinical consequence cohort of patient contribute controls COVID-19 COVID-19 progression COVID-19 severity damage-associated molecular pattern disease disparate early stage elevated epithelial Evidence Express expression General population Genes Health heme IFNAR IL-6 Immune cell independent induce Inflammation inhibit interferon interferon-stimulated gene ISG ISGs limit majority mechanism multiple study myxovirus resistance interferon stimulated genes Neutralizing antibodies neutrophil outcome pandemic Pathways Patient pattern recognition receptor Potential progression promote protective role PRRs receptor Recognition reduced released reported response responses SARS-CoV-2 SARS-COV-2 infection SCD Sickle Sickle cell disease signature stimulated Support supported susceptibility TLR4 TNFα Type type 1 interferon type 1 interferons type I interferon vascular endothelial cells viral infection viral replication Virus Disease while [DOI] 10.3389/fmed.2021.679030 PMC 바로가기 [Article Type] Medicine