Polymorphisms in TLRs influence circulating cytokines production in Plasmodium vivax malaria: TLR polymorphisms influence cytokine productions in malaria-vivaxarticle Published on 2018-10-312024-09-01 Journal: Cytokine [Category] 말라리아, [키워드] Cytokines Infection P. vivax SNPs TLRs [Article Type] article
Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazilarticle Published on 2018-02-282024-09-01 Journal: Human Immunology [Category] 말라리아, [키워드] Brazilian population Gene frequency Genetic polymorphism TLRs [Article Type] article
Orally administered live attenuated Salmonella Typhimurium protects mice against lethal infection with H1N1 influenza virusArticle Published on 2017-03-012023-06-24 Journal: Veterinary microbiology [Category] 신종인플루엔자, [키워드] H1N1 Innate immunity protection Salmonella Typhimurium TLRs [DOI] 10.1016/j.vetmic.2017.01.006
Treatment of hepatitis B virus: an updateReview Published on 2016-12-012023-06-18 Journal: Future Microbiology [Category] B형 간염, [키워드] cccDNA eradication HBV hepatitis B TLRs Toll-like receptors [DOI] 10.2217/fmb-2016-0128 PMC 바로가기 [Article Type] Review
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusMicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while [DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article
Immunogenomics and systems biology of vaccinesArticle Published on 2011-12-212024-09-02 Journal: Immunological reviews [Category] 대상포진, [키워드] Adaptive immunity APCS Innate immunity PAMPs PRRs TLRs [DOI] 10.1111/j.1600-065X.2010.00971.x PMC 바로가기 [Article Type] Article
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsResearch Article Published on 2009-06-082022-10-27 Journal: BMC Immunology [Category] Coronavirus, [키워드] 2003 Apoptosis biological significance Blood CCR chemokine Chemokine receptor compared DC DCs death dendritic cell explain expression Fa facilitate Gene Gene Expression Immune escape induce Infected Infection involved Ligand lung infiltration lymph nodes lymphocyte lymphoid mechanism Migration modulate monocyte outbreak provide receptor reported response Result SARS Coronavirus SARS patients SARS-CoV severity significantly TLRs Toll-like receptor Toll-like receptors TRAIL unique upregulation virus [DOI] 10.1186/1471-2172-10-35 PMC 바로가기 [Article Type] Research Article
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsResearch Article Published on 2009-06-082022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] 2003 Apoptosis biological significance Blood CCR chemokine Chemokine receptor compared DC DCs death dendritic cell explain expression Fa facilitate Gene Gene Expression Immune escape induce Infected Infection involved Ligand lung infiltration lymph nodes lymphocyte lymphoid mechanism Migration modulate monocyte outbreak provide receptor reported response Result SARS Coronavirus SARS patients SARS-CoV severity significantly TLRs Toll-like receptor Toll-like receptors TRAIL unique upregulation virus [DOI] 10.1186/1471-2172-10-35 PMC 바로가기 [Article Type] Research Article