translational – Page 6 – Communicable Diseases Research

Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy

새로운 바이러스 변종, 획기적인 감염 및 백신 주저에 직면하여 Covid-19 완화

Review

Published on 2022-02-012022-09-11
Journal: Journal of autoimmunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Research

Published on 2022-01-312022-10-05
Journal: Nature Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘,

Promising Assays for Examining a Putative Role of Ribosomal Heterogeneity in COVID-19 Susceptibility and Severity

Review

Published on 2022-01-282022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] analyses Antiviral treatment arise assays for proteins assays for RNA sequence and structure caused Characteristics characterized clinical sample clinical setting component concurrent COVID-19 COVID-19 disease Critical detect droplet Efficacy element environmental cues Examining generate heterogeneity Host host susceptibility identify include Infection Messenger RNA modifications mRNA Nanopore organism post-translational modification protocol responses ribosomal heterogeneity ribosomal protein ribosomal proteins ribosomal RNA ribosomal RNAs ribosome ribosomes RNA genome RNA sequencing role rRNA rRNAs SARS-CoV-2 SARS-CoV-2 coronavirus selected sequence Sequencing severity of symptoms Side effect Single Cell Statistical power structural variations structures substrate Symptoms the disease the SARS-CoV-2 transcript translate translation translation machinery translational Transmissibility unique vaccine immunogenicity vaccine response variant viral infectivity
[DOI] 10.3390/life12020203 PMC 바로가기 [Article Type] Review

Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19

Physiology

Published on 2022-01-272022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] abnormality addition Asymptomatic Asymptomatic carrier baseline carrier Cohort Compound Concentration COVID-19 COVID-19 infection COVID-19 pandemic demonstrated drug Duration early phase ECG Effect Efficacy electrical field HCQ healthy healthy donors Hydroxychloroquine identify IMPROVE in vitro induced pluripotent stem cells inhibiting investigated Long Long QT syndrome Mutation Patient patients pharmacological interventions populations Potential Precision precision medicine Prognosis QT interval Replication rule safety pharmacology SARS-CoV-2 SARS-COV-2 infection silent susceptibility symptomatic symptomatic patient translational treat variant while
[DOI] 10.3389/fphys.2021.730127 PMC 바로가기 [Article Type] Physiology

A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells

SARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다

Article

Published on 2022-01-262022-09-11
Journal: Journal of Virology [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle
[DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article

Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients

Bioengineering and Biotechnology

Published on 2022-01-262022-10-31
Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19,

Protease Activated Receptors: A Pathway to Boosting Mesenchymal Stromal Cell Therapeutic Efficacy in Acute Respiratory Distress Syndrome?

Review

Published on 2022-01-242022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus,

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과

Research Article

Published on 2022-01-212022-09-10
Journal: eLife [Category] 변종,

[키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured
[DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article

Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

SARS-CoV-2 감염 및 세포 가소성을 요약하기 위한 조직 수준 폐포 상피 모델

Article

Published on 2022-01-192022-09-12
Journal: Communications Biology [Category] SARS, 진단, 치료제,

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

siRNA로 게놈 SARS-CoV-2 RNA를 표적화하면 바이러스 복제 및 확산을 효율적으로 억제할 수 있습니다.

AcademicSubjects/SCI00010

Published on 2022-01-112022-09-10
Journal: Nucleic Acids Research [Category] 진단, 치료제,

[키워드] 3′ end active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral efficacy approach cell entry conserved conserved region Coronavirus-2 COVID-19 discontinuous transcription effective Ex vivo Frame genomic genomic RNA gRNA human lung inhibited Open reading frame open reading frame 1 ORF1 Prevent Prophylactic Region replicate Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sgRNA sgRNAs siRNA siRNAs Spread target targeting therapy transcript Transcription transcripts translational unique Verifying Viral viral replication Viral RNA viral transcript viral transcripts virus-induced cell death
[DOI] 10.1093/nar/gkab1248 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010