underlie – Page 6 – Communicable Diseases Research

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients

특발성 폐섬유증 및 만성 폐쇄성 폐질환 환자에 대한 SARS-CoV-2 감염의 영향을 확인하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2021-09-022022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술,

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

중증 COVID-19에서 SARS-CoV-2 감염에 대한 국소 고유 면역 손상

Article

Published on 2021-09-022022-09-11
Journal: Cell [Category] Fulltext, SARS, 유전자 메커니즘,

[키워드] Abstract Anti-viral Anti-viral immunity anti-viral response anti-viral responses antiviral response AZGP1 Cell Cell loss cell tropism cells changes in ciliated ciliated cell correlates of immunity COVID-19 detrimental epithelia epithelial epithelial cell epithelial cells epithelial immunity expansion Express Genes goblet healthy heterogenous Human identify Immunity Impaired individual induce infected individuals Infection influence interferon intrinsic KRT13 leads Local Mild Moderate COVID-19 nasal nasal mucosa Nasopharyngeal swab nasopharyngeal swabs nasopharynx observé participant Participants performed Protective respiratory respiratory epithelium response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA scRNA-seq secretory severe COVID-19 severe disease susceptibility target target cells underlie upper respiratory symptoms Viral viral loads viral pathology
[DOI] 10.1016/j.cell.2021.07.023 PMC 바로가기 [Article Type] Article

Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia

인간 비강 상피에서 주요 SARS-CoV-2 진입 인자의 연령 및 기도 질환 관련 유전자 발현 패턴

Article

Published on 2021-09-012022-09-11
Journal: Virology [Category] SARS, 바이오마커,

Risk Factors of SARS-CoV-2 Infection: Global Epidemiological Study

Original Paper

Published on 2021-08-262022-10-29
Journal: Jmirx Med [Category] COVID-19,

[키워드] advanced age age agency Analysis Characteristics Chronic kidney disease clinical observation Comorbidities Comorbidity concerning conditions consequence coronary disease correlation country COVID-19 COVID-19 case Cutoff disease Diseases Epidemiology Ethnic groups Factor fatality Fatality rate Frequency Government greater greatest number immune system increase increased risk Infection infection with SARS-CoV-2 Infectious disease influence Influenza measure Mortality National objective observed correlation pandemic physical physiological Population public health Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection Severity of infection statistical Support susceptibility underlie variety
[DOI] 10.2196/28843 PMC 바로가기 [Article Type] Original Paper

Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range

비강 점막의 면역 세포 거주는 연령대의 호흡기 질환 심각성을 부분적으로 설명 할 수 있습니다.

Article

Published on 2021-08-052022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Adults age analyzed antiviral properties applied Cell cell type cellular changes in children correlated COVID-19 severity epigenome epithelial cell epithelial cells Evidence explain Functional genomics generate healthy individual healthy individuals immune immune activation Immune cell immune cell type immunization strategies individual infection with SARS-CoV-2 innate immune response innate immune system Mucosal immunology nasal nasal mucosa Previous studies previous study proportion reflect resource respiratory Respiratory disease respiratory infection robust SARS-CoV-2 Sequencing severity Single-cell RNA-sequencing suggested T cell transcriptional underlie uninfected
[DOI] 10.1038/s41598-021-95532-3 PMC 바로가기 [Article Type] Article

COVID-19 Disease, Women’s Predominant Non-Heparin Vaccine-Induced Thrombotic Thrombocytopenia and Kounis Syndrome: A Passepartout Cytokine Storm Interplay

Review

Published on 2021-08-052022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] accompanied acute respiratory syndrome Adverse reactions allergenic anaphylaxis approach Better cardiovascular complication Cell complications complications of COVID-19 coronary syndrome coronavirus Coronavirus disease 2019 correlation COVID-19 COVID-19 pandemic cytokine Cytokine storm database excessive immune response glycol Google hematologic heparin heparin-induced thrombocytopenia Hypoxemia hypoxic identify immunodeficiency immunological inflammatory cell Injury Kounis syndrome manifestation mechanism microthrombi Multiorgan myocardial injury neurological Pandemics pathophysiological mechanisms pathophysiology patients with COVID-19 post vaccination post-COVID-19 vaccination Prevalence pro-inflammatory cytokine release renal rupture SARS-CoV-2 similarities storm syndrome thrombocytopenia thrombosis thrombotic event Treatment underlie Vaccine variant venous viral infection virus was performed
[DOI] 10.3390/biomedicines9080959 PMC 바로가기 [Article Type] Review

Interleukin-6 level is an independent predictor of right ventricular systolic dysfunction in patients hospitalized with COVID-19

Observational Study

Published on 2021-08-012022-10-05
Journal: Anatolian journal of cardiology [Category] 임상,

E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability

전자담배와 폐 ACE2 발현: 코로나바이러스 취약성에 대한 시사점

Article

Published on 2021-08-012022-09-11
Journal: Environmental toxicology and pharmacology [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 expression ACE2 mRNA Acetylcholine acetylcholine receptor Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 appear Blood blood sampling both sexes changes cigarette coronavirus Coronavirus infection correlation COVID-19 COVID-19 infection downregulated E-cigarette expression female females Human individual Individual differences Infection investigated lung lung tissue male mechanism mice Nicotine Nicotine. not differ Protein receptor respiratory symptoms reveal severe respiratory symptom severe respiratory symptoms significant increase smoking subunit These data underlie viral entry with COVID-19
[DOI] 10.1016/j.etap.2021.103656 PMC 바로가기 [Article Type] Article

Predictors of venous thromboembolism in patients with COVID-19 in an underserved urban population: A single tertiary center experience

소외된 도시 인구에서 COVID-19 환자의 정맥 혈전 색전증 예측자: 단일 3차 센터 경험

Article

Published on 2021-08-012022-09-11
Journal: The clinical respiratory journal [Category] MERS, SARS, 바이오마커,

[키워드] addition Admission analyzed AUC center characteristic Clinical characteristics collected COVID-19 COVID-19 patient Cutoff D-dimer D-dimer level D-dimer levels death deficiency demographic demographic and clinical characteristics Factor Final Hospitalized intubation lack marker multivariable logistic regression Novel coronavirus obstructive sleep apnea on admission Patient patient data patients with COVID-19 peak peak D-dimer Philadelphia predictors Prophylaxis Prospective Study receiver operating characteristic reported Retrospective analysis ROC SARS-COV-2 infection Sensitivity and specificity significantly higher significantly increased sleep apnea systemic inflammation T-tests Thromboembolism underlie vasopressor requirement vasopressor requirements Venous Thromboembolism VTE VTE risk
[DOI] 10.1111/crj.13377 PMC 바로가기 [Article Type] Article

Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV

Review

Published on 2021-07-282022-10-30
Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases [Category] COVID-19,

[키워드] Acute kidney injury Affect AKI angiotensin-converting enzyme 2 Apoptosis caused chronic inflammation complex COVID-19 critical patient cytokine Cytokine storm demonstrated disease Diseases endothelial cells epithelial cell explain favor glomerular Glomerulonephritis HBV HCV Hepatitis hepatitis B hepatitis C highlight HIV HIV-infected patient human host cells IFN-γ IL-1β IL-8 immunodeficiency in viral increase in increased vascular permeability infect Infection infections Inflammasome Inflammation Inflammatory Inflammatory cytokine kidney kidney damage kidney dysfunction kidneys local inflammation mechanism Particle pathophysiology Podocytes Prognosis receptor renal renal dysfunction Renal involvement renal tubular SARS-CoV-2 Thromboembolic event TNF-α underlie viral disease viral infection Volume
[DOI] 10.1590/1678-9199-JVATITD-2020-0154 PMC 바로가기 [Article Type] Review