IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohortArticle Published on 2022-09-012022-11-15 Journal: Genes and Immunity [Category] SARS, 진단, [키워드] 95% CI adverse effect Affect allele Amino acid carrier cohorts COVID-19 COVID-19 cohort Critical Critical disease death explained functions genotyped ICU IgG3 IGHG3 immune adaptive response impair increased risk induce less moderate-severe Mortality neutralization Patient phagocytosis plasma polymorphism reduce reduced risk risk of COVID-19 risk of death S allele SARS-CoV-2 sequence severity Spanish Variation viral neutralization [DOI] 10.1038/s41435-022-00179-3 PMC 바로가기
Fatality assessment and variant risk monitoring for COVID-19 using three new hospital occupancy related metricsResearch article Published on 2022-09-012022-10-05 Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] analyses average Case fatality rate (CFR) caused CFR changes in country COVID-19 COVID-19 hospitalization COVID-19 severity death described discharge early stage Estimated fatality Fatality rate finding funding hospital Hospital mortality Hospital occupancy mortality rate (HOMR) mathematical Metrics mortality rate Multiple omicron pandemic Range-to-mean ratio (R/M) Ratio of hospital occupancy to cases (HOCR) Ratio of total deaths to hospital occupancy (TDHOR) risk severity of COVID-19 variant Variation were used [DOI] 10.1016/j.ebiom.2022.104225 [Article Type] Research article
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers and household contactsCOVID-19 양성 고위험 근로자 및 가구 접촉자를 식별하기 위한 타액 및 가글 샘플의 사용자 수용성Article Published on 2022-09-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] analyzed approach Cohort collected comparable COVID-19 COVID-19 pandemic diagnostics Disease diagnosis gargle Health care Health care worker health care workers household contact individual limitation nasopharyngeal NTS overcome Patient population surveillance positive positive individual positive individuals Saliva sample collection specificity storage storage conditions subsequent Surveillance Swab throat swab throat swabs user Variation Viral RNA viral titer viral titers [DOI] 10.1016/j.diagmicrobio.2022.115732 PMC 바로가기 [Article Type] Article
Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central PennsylvaniaArticle Published on 2022-09-012022-11-16 Journal: Journal of environmental quality [Category] 치료기술, [키워드] acute respiratory syndrome affected analyzed Antibiotics Area authority calculated collected Concentration concentrations connection coronavirus COVID-19 pandemic Dexamethasone doxycycline effective explained facility FIVE Health highlight hospitalized patient Hydroxychloroquine Impact Medicine no correlation occurred pandemic patients with COVID-19 persistence plant plants powerful tool Quotient Reclamation Remdesivir returned reuse risk Sample state Surveillance therapeutic agent treated Treatment university utility Variation virus water with COVID-19 would increase [DOI] 10.1002/jeq2.20398 PMC 바로가기
Herpesvirus infections and post-COVID-19 manifestations: a pilot observational study헤르페스 바이러스 감염 및 코로나19 이후 발현: 파일럿 관찰 연구Observational Study Published on 2022-09-012022-09-11 Journal: Rheumatology International [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] abnormality accompanied Activation An autoimmune disease Autoimmune Autoimmune disease Cellular immune response clinical and laboratory features CMV complicate contributing to control group controls Course COVID-19 CRP D-dimer detectable Diseases disorders DNA EBV elevated Epstein–Barr virus exaggerate female Fever headache Herpe herpes Herpes virus herpes viruses herpesvirus herpesviruses high mortality high risk Immunocompromised Infection infections laboratory feature liver enzymes male manifestation median age myalgia Numerous Pathologies Patient Reactivation recruited reported rheumatology SARS-CoV-2 severe COVID-19 Spread subject suppressed syndrome temperature the disease Variation variety virus virus infection [DOI] 10.1007/s00296-022-05146-9 PMC 바로가기 [Article Type] Observational Study
The significance of surface neutrophilic MPO expression level in NETosis and NETosis-associated coagulopathies in covid-19 infected patientsResearch article Published on 2022-09-012022-10-05 Journal: Blood cells, molecules & diseases [Category] 바이오마커, 진단, [키워드] analyzed association Biomarker CLIA Coagulopathies Coagulopathy Concentration correlated correlation diagnostic value disease severity ELISA evaluate expression expression level finding flow cytometry four groups IL-6 IL-6 levels immunothrombosis infected patient Infection marker MPO myeloperoxidase NETosis NETs Neutrophil extracellular trap neutrophilic outcomes Patient plasma Prognostic factor reduced Result risk serum Serum level Surface myeloperoxidase triggering Variation were measured [DOI] 10.1016/j.bcmd.2022.102676 [Article Type] Research article
Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)Droplet Digital PCR(RT-ddPCR)을 사용한 SARS-CoV-2 Omicron 변이체의 빠르고 정확한 식별Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Allelic discrimination amino acids B.1.1.529 B.1.1.529. Clinical treatment clinician Concentration confounding factor Delta described develop digital PCR Efficacy Frequency genome sequence Genome sequences genotyping identify Laboratory medium Mutation mutations NGS omicron Omicron variants positive Prevalence primer probe sequences problem professionals Protein public health Rapid reaction Receptor binding domain respiratory viruses RNA robust S-gene SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants Sensitivity and specificity shifting specimen spike Spike protein state substantial reduction substantial reductions susceptibility tested the SARS-CoV-2 therapy Transmission Transport transport medium Vaccine vaccine efficacy variant variants Variation Washington [DOI] 10.1016/j.jcv.2022.105218 PMC 바로가기 [Article Type] Article
Visual diagnosis of COVID-19 disease based on serum metabolites using a paper-based electronic tongueResearch article Published on 2022-09-012022-10-05 Journal: Analytica chimica acta [Category] 진단, 치료기술, [키워드] Accuracy age Array-based sensor calculated caused chemometrics collected colorimetric detection complexes Compound Concentration Control control sample correlation COVID-19 COVID-19 disease COVID-19 patient diagnosis of COVID-19 disease Diseases element human serum information men and women metabolite metabolomics PCR test point-of-care rapid detection response resulting serum serum sample severity statistical the disease tongue Variation viral infection Viral load Visual [DOI] 10.1016/j.aca.2022.340286 [Article Type] Research article
Impact of SARS-CoV-2 Omicron on Rapid Antigen Testing Developed for Early-Pandemic SARS-CoV-2 VariantsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome affected Antigen antigen test B.1.177 BA.2 BA.5 circulating collected coronavirus COVID-19 Ct-value detection rate Developed diagnostic Europe evaluated Evidence false-negative FDA identify Immunity Impact impair increased risk less molecular nasopharyngeal North America nucleocapsid protein omicron pandemic Patient point-of-care positive Postinfection provide Rapid Rapid antigen tests RAT RATs reduced remained RNA SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significantly spreading Swab Testing Transmission variant variants Variation [DOI] 10.1128/spectrum.02006-22 PMC 바로가기