Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium사람의 기도 상피에서 SARS-CoV-2 진입 및 발아에 대한 미세구조적 통찰력Article Published on 2022-03-252022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] ACE2 airway epithelium B.1.1.7 B.1.1.7 variant budding cilia ciliary ciliated ciliated cell ciliated cells Concentration direct fusion envelope epithelial cells examined excluded explain Extracellular Genome goblet host cells Human airway epithelium Intact isolate isolates mechanism membrane membranes microvilli nucleocapsid nucleocapsids periphery plasma membrane profile profiles S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells TMPRSS2 tomography transmission electron microscopy Viral viral entry viral membrane virion virions virus [DOI] 10.1038/s41467-022-29255-y PMC 바로가기 [Article Type] Article
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation흡입 가능한 SARS-CoV-2 모방 입자는 다면 발현 항원 제시를 유도합니다Article Published on 2022-03-142022-09-11 Journal: Biomacromolecules [Category] Coronavirus, SARS, 변종, [키워드] alveolar macrophage Alveolar macrophages carrier caused cellular Community Compliance coronavirus coronavirus disease Coronavirus disease 2019 death distribution elicit epithelial cells Evidence feature glycosaminoglycan IgA level immune cells immune response immune responses Immunity immunization in vitro less lung lung epithelial cell Lung epithelial cells macromolecular Macrophage macrophages mice Mimetic mucosa mucosal mutant nucleic acid Particle Pathogenesis peptide plasmids pleiotropic presentation respiratory tract SARS-CoV-2 single dose target the SARS-CoV-2 topography Vaccine Vaccine hesitancy viral antigens virion [DOI] 10.1021/acs.biomac.1c01447 PMC 바로가기 [Article Type] Article
From delta to Omicron: S1-RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants델타에서 오미크론으로: SARS-CoV-2 정의된 변이체에서 S1-RBD/S2 돌연변이/결실 평형Review Published on 2022-03-102022-09-11 Journal: Gene [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect affected Alpha alteration beta-CoV beta-CoVs Corona COVID-19 defined domain elevated functional Genome glycoprotein involved Lineage mechanism MERS-CoV modify mutations national health system new SARS-CoV-2 omicron Phylogenetic RBD Re-infection respiratory RNA RNA sequence RNA sequences S1/S2 SARS-CoV SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 virus Severe acute respiratory syndrome similarity spike subunit Transmissibility unique variant variants virion virus virus-cell membrane fusion WHO [DOI] 10.1016/j.gene.2021.146134 PMC 바로가기 [Article Type] Review
An intra-cytoplasmic route for SARS-CoV-2 transmission unveiled by Helium-ion microscopyArticle Published on 2022-03-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료제, [키워드] ACE2 alternative route angiotensin Cell Cell signalling connection docking docking mechanism event explain extracellular vesicle feature Host host cell immune infected cell Infection intracellular assembly membrane-bound Microscopy molecular performed released SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 transmission SARS-CoV-2 virion spike glycoprotein Surveillance Vero E6 cell Viral transmission virion [DOI] 10.1038/s41598-022-07867-0 PMC 바로가기 [Article Type] Article
Increasing the frequency of omicron variant mutations boosts the immune response and may reduce the virus virulence오미크론 변이 돌연변이의 빈도를 높이면 면역 반응이 향상되고 바이러스 독성이 감소할 수 있습니다Article Published on 2022-03-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 변종, [키워드] ACE2 receptor Alter Beta boost changes in coronavirus COVID-19 determine Final Frequency immune response Increasing Infection Interaction Mutation mutations omicron Omicron variant Preliminary data Protein reduce Research S protein S protein variant SARS-CoV-2 South Africa stimulate Symptoms the S protein variant virion virulence virus wild strain Wuhan [DOI] 10.1016/j.micpath.2022.105400 PMC 바로가기 [Article Type] Article
Evaluation of virucidal activity of residual quaternary ammonium-treated surfaces on SARS-CoV-2SARS-CoV-2에 대한 잔류 4차 암모늄 처리 표면의 살바이러스 활성 평가Article Published on 2022-03-012022-09-11 Journal: American journal of infection control [Category] SARS, 변종, [키워드] Ammonium Antimicrobials Antiviral effect applied Belgium biosafety level BSL-3 communicability conditions conducted contaminated surfaces COVID-19 COVID-19 pandemic Degradation demonstrated effective evaluated fomites global health HCoV hCoV-19/Australia/VIC01/2020 Health help independent indicate inoculation isolate Laboratory Level methodology performed proliferation qRT-PCR Quantitative reduce reduction reductions Registered residual RNA SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant silane Support supported surfaces sustained Transmission transmission of SARS-CoV-2 treated Viral RNA virion virucidal virulent [DOI] 10.1016/j.ajic.2021.10.021 PMC 바로가기 [Article Type] Article
A reduced graphene oxide-Fe 3 O 4 composite functionalized with cetyltrimethylammonium bromide for efficient adsorption of SARS-CoV-2 spike pseudovirus and human enteric virusesSARS-CoV-2 스파이크 슈도바이러스 및 인간 장내 바이러스의 효율적인 흡착을 위해 세틸트리메틸암모늄 브로마이드로 기능화된 환원그래핀옥사이드-Fe 3 O 4 복합체Article Published on 2022-03-012022-09-11 Journal: Chemosphere [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption cetyltrimethylammonium bromide Combination complex Composite coronavirus CTAB Detection limit electrostatic interaction electrostatic interactions exhibited Fourier-transform infrared spectroscopy Genome HRV Human Human enteric viruses infrared spectroscopy intrinsic pseudovirus public health qPCR analysis reduced Reduced graphene oxide SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike pseudovirus severe acute respiratory syndrome Coronavirus significantly tap transmission electron microscopy Viral transmission virion Virion adsorption. virions virus virus particle virus particles water X-ray diffraction zeta potential [DOI] 10.1016/j.chemosphere.2021.132995 PMC 바로가기 [Article Type] Article
Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 InfectionResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] N-glycosylation Ablation acute respiratory syndrome Antiviral agents B.1.1.7 B.1.351 B.1.617.2 Beta binding block Cell conditions coronavirus Coronavirus-2 COVID-19 Critical Delta FDA-approved drugs Gamma glycan glycosylate glycosylation Host host cell host immunity host receptor immunotherapies Infection inhibition inhibitors Invasion investigated modulate N -glycosylation P.1 pathway predicted produced Protein reduced RNA interference SARS-CoV-2 SARS-CoV-2 N Spike proteins Spread Treatment Vaccine variant viral infection virion [DOI] 10.1128/mbio.03718-21 PMC 바로가기 [Article Type] Research Article
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein합성 비리온은 SARS-CoV-2 스파이크 당단백질의 지방산 결합 적응 면역원성을 나타냅니다.Article Published on 2022-02-142022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adaptive binding binding pocket Bioinspired materials Cell conserved convalescent COVID-19 COVID-19 progression Dexamethasone Donor fatty Fatty acid fatty acids FDA-approved drug FFAs free fatty acid function global public health glycoprotein heterogenous Host immune response immunogenicity Immunoglobulin immunoglobulins Inflammation Inflammatory integrin Live virus mechanism mimicking modulate molecular motif Mutant SARS-CoV-2 neutralization activity Neutralizing open Pathogenesis preparation pro-inflammatory proinflammatory protocol RBD Receptor binding Receptor binding domain Regulation Regulatory responsible reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein synthetic the SARS-CoV-2 Variability Viral virion vitamin K wild-type [DOI] 10.1038/s41467-022-28446-x PMC 바로가기 [Article Type] Article
Exploring Mitochondrial Localization of SARS-CoV-2 RNA by Padlock Assay: A Pilot Study in Human PlacentaCommunication Published on 2022-02-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome addition cells checked coronavirus correlated COVID-19 COVID-19 pandemic Evidence formalin-fixed paraffin-embedded genomic glycoprotein Human knowledge Localization Mitochondria mitochondrial mitochondrion overlapping padlock pilot study Placenta placental provide Region Research RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA single-stranded positive-sense suggested Support the SARS-CoV-2 genome tissue virion [DOI] 10.3390/ijms23042100 PMC 바로가기 [Article Type] Communication