Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeqArticle Published on 2021-05-252022-10-04 Journal: Nature Communications [Category] SARS, 진단, [키워드] Amplicon Analysis can be used COVID-19 pandemic demonstrated detect diagnose diagnostic diagnostics gold standard Human rhinovirus Infection Laboratory MONITOR other respiratory infection other respiratory virus pandemic pathogenic agents Pathogens PCR-based techniques performed Quantitative RNA RNA sequencing robustness RT-PCR Saliva SARS-CoV-2 sensitivity Sequencing Spread unique viral infection viral spread virions virus [DOI] 10.1038/s41467-021-22664-5 PMC 바로가기 [Article Type] Article
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replicationSARS-Cov-2 뉴클레오캡시드 단백질의 아르기닌 메틸화는 RNA 결합, 스트레스 과립 형성 억제 능력 및 바이러스 복제를 조절합니다Research Article Published on 2021-05-232022-09-10 Journal: The Journal of Biological Chemistry [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AP, affinity-purification arginine arginine methylation assembly binding blocked cancer treatment Cell culture clinical trial clinical trials component condensate coronavirus CTD, C-terminal dimerization domain defined DMSO, dimethylsulfoxide dose-dependent manner drugs FBS, fetal bovine serum Flag-N, Flag-epitope N protein G3BP1 genomic RNA GSK-3, glycogen synthase kinase 3 HEK293 cells hnRNPA1, heterogeneous nuclear ribonucleoprotein A1 host antiviral response host protein inhibited inhibiting inhibitor inhibitors Interaction life cycle lysine MERS-CoV, Middle East respiratory syndrome coronavirus methylarginine methylated Methylation methyltransferase motifs N protein N, nucleocapsid NTD, N-terminal RNA-binding domain nucleocapsid (N) protein nucleocapsid protein PAR-CLIP, photoactivatable ribonucleoside–enhanced crosslinking and immunoprecipitation PFA, paraformaldehyde PRMT1 PRMTs, protein arginine methyltransferases property Protein protein 3 RBP, RNA binding protein reduced regulate regulated required residue residues respiratory RGG/RG motif RIP, RNA immunoprecipitation RNA RNA binding S, spike SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequences severe acute respiratory syndrome Coronavirus SGs, stress granules significantly SMN, survival of motor neuron SR, serine/arginine-rich SRPK, SRSF protein kinase Stage Stress stress granule stress granules Substitution substrates suppress TDRD3, Tudor domain-containing protein 3 the N protein therapeutic Treatment Type type I type I PRMT inhibitor VeroE6 cell VeroE6 cells Viral viral genome viral life cycle Viral protein Viral proteins viral replication virion virions vRNP, viral ribonucleoprotein [DOI] 10.1016/j.jbc.2021.100821 PMC 바로가기 [Article Type] Research Article
A guideline to limit indoor airborne transmission of COVID-19416 Published on 2021-04-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] activities acute respiratory syndrome aerosol droplet Airborne transmission arise available data build case study Contact tracing coronavirus COVID-19 dimension disease transmission distributions estimate event Face mask Face masks facilitate filtration indoor safety guideline infectious aerosol infectious dose limit magnitude New coronavirus new virus offer outbreak pandemic status Particular PROTECT provided reduced respiratory activity respiratory aerosols respiratory droplet risk rule SARS-CoV SARS-CoV-2 coronavirus Significance social distancing thought Transmission Ventilation virions while [DOI] 10.1073/pnas.2018995118 PMC 바로가기 [Article Type] 416
SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike ParticlesSARS CoV-2 핵단백질은 렌티바이러스 스파이크 입자의 감염성을 향상시킵니다Cellular and Infection Microbiology Published on 2021-04-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료법, [키워드] ACE2 ACE2-Fc BSL-2 cells cellular entry D614G enhancer Entry inhibitor entry inhibitors fused Genes implication Infectivity Interpretation lentiviral less mutant N protein Neutralizing neutralizing effect nucleocapsid nucleoprotein ORF Particle particle infectivity Particles pathogen performed produced SARS CoV SARS CoV-2 SARS-CoV-2 spike spike lentiviral pseudotyping Spike protein the spike protein virion virions Virus neutralization while wild-type [DOI] 10.3389/fcimb.2021.663688 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulenceSARS-CoV-2에 대한 트랜스 보완 시스템은 독성 없이 진정한 바이러스 복제를 요약합니다.Article Published on 2021-04-152022-09-11 Journal: Cell [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral biosafety level Biosafety Level 3 BSL-2 laboratory BSL-3 can be used Cell cell line Complementation component coronavirus COVID-19 Culture deleted deletions detectable Diagnosis disease dose envelope gene exhibited expressing gene deletions generate Genes genomic hamster hamsters highest infect inoculated K18-hACE2 transgenic mice level 3 mutated naive cells neutralization ORF3 platform Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus trans transcriptional regulator Vaccine Viral viral replication Viral RNA virion virions virulence wild-type SARS-CoV-2 [DOI] 10.1016/j.cell.2021.02.044 PMC 바로가기 [Article Type] Article
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopyMajor Article Published on 2021-04-122022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID-19, MERS, SARS, [키워드] alveolar alveolar damage Apoptosis can be used capillary cellular debris Characteristics characterized circulating component coronavirus correlation COVID-19 Cytopathic effect DAD died diffuse Diffuse alveolar damage edema effective electron microscopy endothelial cells Endothelium epithelial evaluate exhibited fibrosis Final Infection Injury lung Lung pathology Lymphocytes macrophages mechanisms membrane multinucleated giant cells Necrosis Particle pathological Patient patients patients with SARS-CoV-2 Platelet pneumocyte Pneumocytes Postmortem evidence predominant proliferation proliferative Pulmonary pathology red blood cell replaced rupture SARS-CoV-2 Severe acute respiratory syndrome 2 the Coronaviridae transmission electron microscopy type I Type II pneumocyte virions Virus-host interaction was used [DOI] 10.1590/0037-8682-0850-2020 PMC 바로가기 [Article Type] Major Article
Computer simulation of the SARS-CoV-2 contamination risk in a large dental clinicARTICLES Published on 2021-03-292022-10-28 Journal: Physics of Fluids [Category] COVID-19, [키워드] acute respiratory syndrome aerosol aerosol-generating procedures Aerosols caused composed Computer simulation Concentration concerning condition Contamination coronavirus COVID-19 droplet droplet transmission evaluate fraction Human humans infect patient treatment public health crisis raise recent required Research risk Saliva SARS-CoV-2 social distancing supplementary material the SARS-CoV-2 threshold Travel variety Ventilation Viral load virions virus [DOI] 10.1063/5.0043934 PMC 바로가기 [Article Type] ARTICLES
Effect of Inactivation Methods on SARS-CoV-2 Virion Protein and StructureSARS-CoV-2 비리온 단백질 및 구조에 대한 비활성화 방법의 영향Article Published on 2021-03-262022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] Antibody detection assays best biosafety biosafety level Biosafety Level 3 BSL3 comparable conditions conducted coronavirus detectable Effect electron microscopy ELISA Genome heat inactivation impacted inactivated inactivation Incubation Infection investigator investigators less level 3 meet protocol purification reduction Research respiratory resulting risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe Acute Respiratory Syndrome Coronavirus -2 Structure Treatment ultraviolet ultraviolet irradiation UV inactivation Viral Viral protein Viral proteins Viral RNA viral RNA quantification viral stocks virion virions virus western blot working [DOI] 10.3390/v13040562 PMC 바로가기 [Article Type] Article
In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2Original Article Published on 2021-03-102022-10-30 Journal: Molecular Therapy [Category] COVID-19, [키워드] absence Abstract anti-viral therapeutics approach CCR5 CD4 cell line cellular co-expressed codon optimization Combination Engineered red blood cells erythrocyte Express expressing expression facilitate fusion protein high expression level HIV-1 Hoffmann Infection Interaction lack neutralization neutralize neutralized nuclei organelle Potential treatment Prevent produced progenitor cell progenitor cells Proteins RBC RBCs receptor receptors red blood cell required SARS-CoV-2 spike transgene trimeric viral entry viral infections viral replication virions [DOI] 10.1016/j.omtm.2021.03.003 PMC 바로가기 [Article Type] Original Article
Elucidating the Antiviral Mechanism of Different MARCH FactorsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] antiretroviral Antiviral Cell comprehensive analysis E3 ubiquitin ligases envelope glycoproteins Factor glycoprotein HIV-1 homologues host restriction factors Human immunodeficiency virus Immunity Infection information intrinsic mechanism Murine leukemia virus plasma membrane Protein Proteins recent reducing restrict retrovirus retroviruses shown transmembrane protein virions viruses [DOI] 10.1128/mBio.03264-20 PMC 바로가기 [Article Type] Research Article