H7N9 influenza virus-like particle based on BEVS protects chickens from lethal challenge with highly pathogenic H7N9 avian influenza virusArticle Published on 2021-07-012023-06-02 Journal: Veterinary microbiology [Category] 조류인플루엔자, [키워드] chicken H7N9 influenza virus recombinant baculovirus Sf9 cells Vaccine virus-like particles [DOI] 10.1016/j.vetmic.2021.109106
Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2SARS-CoV-2에 대한 특정 균질 발광 효소 리포터 분석의 구조 기반 설계Article Published on 2021-06-252022-09-11 Journal: Journal of Molecular Biology [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody applied assays binding C-terminal catalytic activity complementary Complementation COVID-19 detectable develop diagnostic enzyme epitope Epitopes Express Gaussia Luciferase high affinity Incubation luciferase other diseases pathogenic PCA promise Protein protein-fragment complementation assay recombinant recombinant antibodies reporter reporters S-protein SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus sensitivity Specific specificity spike spike (S) protein steric the SARS-CoV-2 virus threat Treatment Trimers Viral viral spike Virus-like particle virus-like particles [DOI] 10.1016/j.jmb.2021.166983 PMC 바로가기 [Article Type] Article
Nanotherapeutics for treating coronavirus diseasesReview Article Published on 2021-06-102023-08-30 Journal: Journal of Drug Delivery Science and Technology [Category] E형 간염, [키워드] Antiviral Coronaviruses COVID-19 immunization Nanoparticles Nanotechnology Vaccine virus-like particles [DOI] 10.1016/j.jddst.2021.102634 PMC 바로가기 [Article Type] Review Article
Production of SARS-CoV-2 Virus-Like Particles in Insect CellsArticle Published on 2021-05-262022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] bacmid baculovirus cause Cell cloned competent COVID-19 disease Escherichia coli expression generate Health Infection insect insect cell insect cells morphology multiple cloning site Particle Plasmid platform Production promoter promoters S gene S protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 VLP virions virus-like particles VLPs were expressed [DOI] 10.3390/vaccines9060554 PMC 바로가기 [Article Type] Article
Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activitySARS-CoV-2 외피 단백질과 아밀로라이드의 상호작용은 항바이러스 활성과 관련이 있습니다Research Article Published on 2021-05-182022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] activity addition Amiloride amilorides antiviral activity antiviral potency Author binding binding affinity binding site biochemical budding C-terminal causative agent change channel inhibitors characterized chemical shift Complete complex conformation conformations contribute correlated COVID-19 COVID-19 treatment cytoplasmic domain Drug discovery E protein envelope exhibit form foundation full-length SARS-CoV-2 group Guidance Health hexadecylphosphocholine hydrophobic information inhibitor inhibitors Interaction interactions ion channel lack linker membrane protein molecular Mutation N-terminal NMR spectroscopy Novel coronavirus novel coronavirus SARS-CoV-2 pandemic pandemic of COVID-19 Pathogenesis Perturbation Protein Protein conformation pyrazine rapid progress residue residues respiratory respiratory infection responsible SARS-CoV-2 SARS-CoV-2 envelope structural protein structural proteins Structure threat transmembrane transmembrane domain Treatment truncation Vaccines Vero E6 VERO E6 cells Viral viral genome Viral proteins viral replication virion assembly virus-like particles while [DOI] 10.1371/journal.ppat.1009519 PMC 바로가기 [Article Type] Research Article
AP205 VLPs Based on Dimerized Capsid Proteins Accommodate RBM Domain of SARS-CoV-2 and Serve as an Attractive Vaccine CandidateArticle Published on 2021-04-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activities aggregate aggregates Analysis antibody AP205-VLPs C terminus candidate capsid caused Convalescent patients COVID-19 denatured dimerized disease displaying domain E. coli expressed fused generate Health humoral immune response IgG antibody immunization immunized mice Impact insoluble Microscopy neutralize neutralizing antibody pandemic produced Proteins RB motif RBD RBM Receptor binding domain receptor binding motif recognizing resulting SARS-CoV-2 Spike protein urea vaccination vaccine candidate virus-like particles VLP were expressed [DOI] 10.3390/vaccines9040403 PMC 바로가기 [Article Type] Article
Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19Molecular Biosciences Published on 2021-04-152022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absence acute respiratory syndrome Ad5-nCoV antigenic protein approaches candidate ChAdOx1-S clinical development computational tool coronavirus COVID-19 COVID-19 vaccine Critical curtail develop development developmental DNA and RNA drug Ebola virus evaluated feature Genetic globe healthcare host cell immune responses inactivated Incubation period indication induce landscape MERS-CoV Novel coronavirus nucleic acid outbreak pandemic peptides platform Potential Prevalence recombinant proteins Research SARS-CoV-2 sequence the disease the vaccine Vaccine vaccine antigen vaccine candidates Vaccines vector vectors Viral vector Viral vector vaccine virus virus-like particles viruses World Health Organization zoonotic [DOI] 10.3389/fmolb.2021.635337 PMC 바로가기 [Article Type] Molecular Biosciences
Assembly and Entry of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2): Evaluation Using Virus-Like Particles중증급성호흡기증후군 코로나바이러스 2(SARS-CoV2)의 조립 및 진입: 바이러스 유사 입자를 이용한 평가Article Published on 2021-04-092022-09-11 Journal: Cells [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus assembly Betacoronavirus BSL-3 can be used cell culture conditions chimeric complementary Complementation coronavirus coronavirus 2 COVID-19 Critical CTD cytoplasmic D614G dependent on domain effective envelope evaluate expressing Factors feature Features functional HiBiT homologous host cell inoculated investigated LgBiT matrix MERS-CoV MHV N protein N proteins NanoBiT technology nLuc nucleocapsid offer Particle peptide produced Proteins Release respiratory SARS-CoV2 secretion supported susceptibility target cell target cells Viral viral membrane virus virus assembly Virus-like particle virus-like particles VLP VLPs was used [DOI] 10.3390/cells10040853 PMC 바로가기 [Article Type] Article
Phase III: Randomized observer-blind trial to evaluate lot-to-lot consistency of a new plant-derived quadrivalent virus like particle influenza vaccine in adults 18-49 years of ageClinical Trial Published on 2021-03-052023-06-23 Journal: Vaccine [Category] 신종인플루엔자, [키워드] Cell-mediated immunity Lot-to-lot Nicotiana benthamiana Plant-derived quadrivalent influenza vaccine Safety and immunogenicity virus-like particles [DOI] 10.1016/j.vaccine.2021.01.004 [Article Type] Clinical Trial
Progress towards the development of a P. vivax vaccineP. vivax 백신 개발을 위한 진전Article Published on 2021-02-032024-08-08 Journal: Expert review of vaccines [Category] 말라리아, [키워드] clinical trials heterologous prime/boost immunizations viral vectors virus-like particles vivax vaccines [DOI] 10.1080/14760584.2021.1880898 PMC 바로가기 [Article Type] Article