A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity2개의 재조합 이량체 RBD COVID-19 백신 후보에 대한 무작위 이중 맹검 1상 임상 시험: 안전성, 반응성 및 면역원성Clinical Trial Published on 2022-03-182022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] adjuvants adverse event anti-RBD Anti-RBD IgG association baseline candidate clinical trial Coronavirus infection COVID-19 COVID-19 vaccine COVID-19 vaccines dimeric dose doses double-blind ELISA evaluated geometric Heterologous highest homologous or heterologous homologous schedule Humoral response immunization schedule immunogenic Immunopotentiator In-vitro intensity Interaction Local Mild MOST neutralization Neutralizing Neutralizing antibodies neutralizing antibody outer membrane Panel performed Phase I Primary outcome Randomized randomly divided RBD reactogenicity receive reported Safe Safety SARS-CoV-2 second dose secondary outcome Seroconversion significantly Spike protein subject the SARS-CoV-2 three group titre toxicology two groups vaccination vaccine candidate vaccine immunogenicity Vaccines Vesicle Volunteer were used [DOI] 10.1016/j.vaccine.2022.02.029 PMC 바로가기 [Article Type] Clinical Trial
Micro-Fourier-transform infrared reflectance spectroscopy as tool for probing IgG glycosylation in COVID-19 patientsCOVID-19 환자에서 IgG 글리코 실화를 조사하기위한 도구로서 마이크로 푸리에 변환 적외선 반사 분광 광경.Article Published on 2022-03-112022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Activation Adaptive immune response Anti-spike antibody Antibody Response Asymptomatic Biophotonics Blood Brazil carbonyl chemiluminescent immunoassay CLIA correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill Cutoff detection rate diagnosed with COVID-19 Diagnostic markers disease dissemination ELISA excessive inflammatory response extension glycosylation healthcare worker healthy helping IgA IgG IgG antibodies IgG1 IgM immune response Immunoglobulin indicated individual individuals with COVID-19 Infection marker Mild Optics and photonics Other photonics outcome Patient patients Physiology positive probe Quantitative RBD reported SARS-CoV-2 SARS-CoV-2 viral load serum sample serum samples severity signal specificity Viral Viral antigen Volunteer worsening [DOI] 10.1038/s41598-022-08156-6 PMC 바로가기 [Article Type] Article
Detection and Contact Tracing of COVID-19 in Indonesia through a Red Cross Community Based Surveillance SystemConference abstract Published on 2022-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 치료기술, [키워드] 24 hours Active surveillance approach CBS Community complement component Contact Contact tracing COVID-19 Critical detect detection Diagnosis disease effective eight event feasible Follow-up visit Health health authorities healthcare facility Human identify individual Indonesia Infectious disease Local local response management many cases material Pandemics PCR positive positive preventive measure public health Red reported Result scaled supported Surveillance System threat tracing undergo Volunteer volunteers [DOI] 10.1016/j.ijid.2021.12.085 [Article Type] Conference abstract
A phase I, first-in-human, randomized dose-escalation study of anti-activated factor XII monoclonal antibody garadacimab항 활성화 인자 XII 단일 클론 항체 garadacimab의 I 상, 최초 인간, 무작위 용량 증량 연구Clinical Trial Published on 2022-03-012022-09-12 Journal: Clinical and translational science [Category] MERS, 임상, 진단, [키워드] activated activities Analysis antibodies blood sample clinical development Coagulation Cohort cohorts collected Contact coronavirus disease COVID-19 deaths demonstrated dose dose-dependent dose-dependent manner dose-escalation Effect eight Factor healthy healthy volunteers increase in increases in inhibit intravenous male monoclonal antibody MOST pathway Phase I Placebo plasma plasma concentration positive proinflammatory Prothrombin time prothrombotic Randomized reported single-center Support TEAE TEAEs tested Tolerability treatment-emergent adverse event Volunteer volunteers [DOI] 10.1111/cts.13180 PMC 바로가기 [Article Type] Clinical Trial
Impact of SARS-CoV-2 on saliva: TNF-⍺, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgMSARS-CoV-2가 타액에 미치는 영향: TNF-⍺, IL-6, IL-10, 락토페린, 리소자임, IgG, IgA 및 IgMArticle Published on 2022-03-012022-09-11 Journal: Journal of oral biosciences [Category] MERS, SARS, 진단, 치료기술, [키워드] acute SARS-CoV-2 infection airway Alter Analysis antimicrobial antimicrobial peptides Asymptomatic carried Chain Reaction components Concentration Control control group COVID-19 COVID-19 symptom COVID-19 symptoms Defense detect diagnosis of SARS-CoV-2 ELISA evaluate female group IgA IgG IgM IL-10 IL-6 immune immunoglobulins Impact increase in Infection Interleukins lactoferrin less longitudinal study lysozyme male Patient patients with COVID-19 PCR peptides polymerase chain polymerase chain reaction Prognosis Real-time PCR recovered patient Saliva salivary SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic significantly symptoms of COVID-19 understanding Volunteer [DOI] 10.1016/j.job.2022.01.007 PMC 바로가기 [Article Type] Article
Evaluation of antibody response after COVID-19 vaccination of healthcare workers의료진의 코로나19 예방접종 후 항체반응 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료법, [키워드] addition age antibody antibody levels Antibody Response antibody response against Antibody titer Antibody titers BMI BMI values body mass body mass index CoronaVac COVID-19 COVID-19 vaccination develop dose effective Elecsy Elecsys evaluated examined Factor female Gender HCW healthcare healthcare worker Healthcare workers immune response Immunity Inactivated vaccine individuals infected with COVID-19 interquartile range IQR male median age nucleocapsid protein obese participant Participants participated postvaccination RBD RBD protein Receptor binding Receptor binding domain Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein second dose second dose of vaccine Seropositivity Smokers smoking Spike protein the receptor-binding domain the SARS-CoV-2 U/mL Vaccine Volunteer volunteers was determined was measured [DOI] 10.1002/jmv.27420 PMC 바로가기 [Article Type] Article
Low-entry-barrier point-of-care testing of anti-SARS-CoV-2 IgG in the population of Upper Austria from December 2020 until April 2021—a feasible surveillance strategy for post-pandemic monitoring?2020 년 12 월부터 2021 년 4 월까지 오스트리아 어퍼 오스트리아 인구에서 항 -SARS-COV-2 IGG의 저지전 배리어 요약 테스트-밴혈 후 모니터링을위한 실행 가능한 감시 전략?Research Paper Published on 2022-02-282022-09-08 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis analyzed anonymized data anti-SARS-CoV-2 IgG antibody antibody levels Antigen approach continuous monitoring coronavirus COVID-19 COVID-19 pandemic defined diagnostic diagnostic testing estimate feasible IgG antibodies IgG antibody immune Immune status Immunoglobulin Immunoglobulin G Infection International limit Local National PCR Peripheral blood Pharmacy point-of-care Population populations Prevalence Rapid test Region reported respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens Seroprevalence severe acute respiratory syndrome Coronavirus Spread Surveillance upper vaccinated individuals Volunteer volunteers [DOI] 10.1007/s00216-022-03966-z PMC 바로가기 [Article Type] Research Paper
Melatonin in the Prophylaxis of SARS-CoV-2 Infection in Healthcare Workers (MeCOVID): A Randomised Clinical TrialArticle Published on 2022-02-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 1:1 Administered administration adverse event clinical clinical trial COVID-19 double-blind Efficacy evaluated FIVE healthcare healthcare worker Healthcare workers high risk hospital Hypothesis incidence inclusion criteria melatonin outcome participant Placebo Prevent prophylactic treatment Prophylaxis randomised receive recruited reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections screened severe adverse event somnolence Spain statistically significant difference Treatment Volunteer worker [DOI] 10.3390/jcm11041139 PMC 바로가기 [Article Type] Article
A Comparative Cross-Sectional Study of the Consequences of the COVID-19 Lockdown on Women’s Health Behaviors in SpainArticle Published on 2022-02-172022-10-30 Journal: Nutrients [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] addition Analysis Anxiety Behavior body weight Care carried change changed changes in Comparative consequence COVID-19 COVID-19 pandemic cross-sectional distribution Gender greater Health health habits Impact lockdown men men and women methodology performed physical activity Result Spain Spanish Stress Volunteer women women’s health [DOI] 10.3390/nu14040846 PMC 바로가기 [Article Type] Article
Recruitment methods and yield rates in a clinical trial of physical exercise for older adults with hypertension—HAEL Study: a study within a trialRandomized Controlled Trial Published on 2022-02-102022-10-04 Journal: BMC Medical Research Methodology [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, [키워드] Adults age calculated Characteristics clinical trial contributed coordinating center demographic characteristics described deviation Effective strategies Electronic health records eligibility criteria enrolled exclusion Frequency groups highest hypertension individual intervention group Lifestyle intervention limitation media MOST Multiple Older participant Participants physical physical activity physically press Prevalence randomization Randomized randomized clinical trial recruitment Recruitment approaches Registered Result screened Sex SWAT Trial Volunteer were excluded women [DOI] 10.1186/s12874-022-01535-7 PMC 바로가기 [Article Type] Randomized Controlled Trial