The performance of COVID-19 Surveillance System as timely containment strategy in Western Oromia, Ethiopia에티오피아 서부 오로 미아의 적시 격리 전략으로서 Covid-19 감시 시스템의 성과Research Published on 2021-12-182022-09-10 Journal: BMC Public Health [Category] SARS, 치료기술, [키워드] 95% CI Analysis association Awareness checked checklist collected Community conducted Contact COVID 19 COVID-19 Critical cross-sectional cross-sectional study dependent variable effective eligible Epidemic Evaluation extension feasible goodness of fit Health health facilities health system high risk Hosmer-lemeshow test hospital independent independent predictor independent predictors independent variable independent variables Intervention multivariable logistic regression Multivariable logistic regression analysis P-value pandemic participant Perceived risk predictor questionnaire reported resident Result risk significance level socioeconomic status status Surveillance surveillance data Suspect System town volunteers were assessed West Ethiopia Wuhan Wuhan, China [DOI] 10.1186/s12889-021-12380-6 PMC 바로가기 [Article Type] Research
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
Evaluation of SARS-CoV-2 in semen, seminal plasma, and spermatozoa pellet of COVID-19 patients in the acute stage of infection감염의 급성 단계에서 COVID-19 환자의 정액, 정액 혈장 및 정자 펠렛에서 SARS-COV-2의 평가Research Article Published on 2021-12-142022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] 24 hour 24 hours acute phase available data Bacteria bacterial DNA Cohort studies cohort study Concentration Contamination COVID-19 COVID-19 patient COVID-19 patients COVID-19 positive patient Culture Fractions hygiene Infection information manual median interval nasopharyngeal swabs nasopharyngeal viral onset of symptom Oropharyngeal Patient pellet plasma positive positive patients positive SARS-CoV-2 PCR protocol reproductive SARS-CoV-2 screened secretion Semen seminal plasma specimen spermatozoa the disease the median the SARS-CoV-2 Viral virus volunteers while [DOI] 10.1371/journal.pone.0260187 PMC 바로가기 [Article Type] Research Article
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsuleLianhuaqingwen Capsule을 투여 한 후 글리 시르 시리 사르 우랄 렌 시스 뿌리 (Gancao)에서 유래 한 슈도 알로 스테 겐 화합물의 약동학 적 식별Clinical Trial Published on 2021-12-012022-08-31 Journal: Acta pharmacologica Sinica [Category] 바이오마커, 임상, 치료제, [키워드] 11β-hydroxysteroid dehydrogenase 2 24-hydroxyglycyrrhetic acid access acid activated bile characterized China circulating metabolite colonic colonic microbiota Combination component components Compound condition COVID-19 COVID-19 treatment dehydrogenase exposure to facilitate feces Gancao-induced pseudoaldosteronism glycyrrhetic acid Glycyrrhiza uralensis glycyrrhizin hepatic human kidney Human plasma implication in vitro induce inhibit inhibiting intestinal intestinal absorption LianhuaQingwen licorice licorice-induced pseudoaldosteronism. liquiritigenin liver membrane permeability metabolism metabolite microbiota pharmacokinetic plasma protein Plasma Protein Binding Protein binding receiving renal Safe Saponin significant level systemic Therapeutic benefit Transport Treatment treatment for COVID-19 tubular reabsorption Volunteer volunteers [DOI] 10.1038/s41401-021-00651-2 PMC 바로가기 [Article Type] Clinical Trial
Associations of neighborhood built, safety, and social environment with walking to and from school among elementary school-aged children in Chiba, JapanResearch Published on 2021-11-272022-10-30 Journal: The international journal of behavioral nutrition and physical activity [Category] Coronavirus, MERS, SARS, [키워드] active travel activities activity analyzed approach association change children Commuting conducted connection covariates COVID-19 COVID-19 pandemic Crime prevention declining defined Environment examined International Japan Japanese maintain multinomial logistic neighborhood New town overcome parent parental Participants positive Prevalence provided public health recent regressions required Result Safety scale School Schools social environment supplementary material Support Travel variables Volunteer volunteers walkability walking was measured [DOI] 10.1186/s12966-021-01202-y PMC 바로가기 [Article Type] Research
SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patientsSARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다Original Article Published on 2021-11-232022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers [DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article
Infection in asymptomatic carriers of SARS-CoV-2 can interfere with the achievement of robust immunity on a population scaleSARS-CoV-2의 무증상 보균자의 감염은 인구 규모의 강력한 면역 달성을 방해할 수 있습니다Animal Published on 2021-11-172022-09-12 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis anti-RBD anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies Asymptomatic Asymptomatic carrier carried cell immunity Cellular immune response cellular immunity circulating Contact contact with coronavirus FIVE followed by generate herd immunity Humoral immunity IgG Immunity immunogenic infected with SARS-CoV-2 Infection interfere municipality pandemic Prevent ranged reduction in robust SARS-CoV-2 Seroconversion seroconversion rates severe acute respiratory syndrome Coronavirus Spread state virus Volunteer volunteers [DOI] 10.1099/jgv.0.001684 PMC 바로가기 [Article Type] Animal
Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated VaccineSARS-COV-2 불활성 백신에 의해 유도 된 항체 및 T 세포에 의한 관심의 변이체 인식Clinical Trial Published on 2021-11-092022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha antibodies antibody approved B.1.1.7 B.1.351 Beta Beta variant binding cellular response Cellular responses Chilean circulating variant clinical trial concern CoronaVac coronavirus D614G death rate Delta delta variant described detect dose elicited ELISPOT enrolled evaluate evaluated Gamma genetic difference genetic differences geometric mean Geometric means house human ACE2 receptor immune response immunization immunization schedule immunization schedules immunized immunogenic in-house ELISA inactivated induced Infection interferon interferon-γ-secreting T cell interferon-γ-secreting T cells Lineage microneutralization neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing capacity P.1 pandemic PBMC PBMCs Phase 3 phase 3 clinical trial promote Protective RBD Receptor binding domain Recognition reduced respiratory responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secreted secretion Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significant differences spike stimulate subject T cell immunity T cells tested the RBD the SARS-CoV-2 the vaccine titers Vaccine variant variants variants of concern virus Volunteer volunteers were used Wuhan Wuhan, China [DOI] 10.3389/fimmu.2021.747830 PMC 바로가기 [Article Type] Clinical Trial
Factors Associated with Reduction in Physical Activity during the COVID-19 Pandemic in São Paulo, Brazil: An Internet-Based Survey Conducted in June 2020Article Published on 2021-10-292022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] activity adjusted adopted Brazilian coronavirus correlated COVID-19 COVID-19 pandemic exercise Factor female greater investigated less male negatively affected pandemic participant physical activity physical activity levels Prevalence proportion questionnaire reduced reduction Sedentarism selected significantly survey volunteers were excluded [DOI] 10.3390/ijerph182111397 PMC 바로가기 [Article Type] Article
Characterization of Individuals Interested in Participating in a Phase I SARS-CoV-2 Vaccine TrialCommunication Published on 2021-10-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age average characterization clinical trial clinical trials Coverage COVID-19 demographic develop disease effective elevated facilitate Factor female health-care highest implementation individual individuals male media motivation MVA-SARS-2-S pandemic participant phase Phase 1 Phase I recruitment reported risk SARS-CoV-2 severe disease the vaccine Trial Vaccine vaccine trial Volunteer volunteers were assessed [DOI] 10.3390/vaccines9101208 PMC 바로가기 [Article Type] Communication