Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article
Effectiveness of CoronaVac in children 3–5 years of age during the SARS-CoV-2 Omicron outbreak in Chile Research Published on 2022-05-232022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Admission age B.1.1.529 benefit caused children Complete Complication conducted confounders CoronaVac coronavirus COVID-19 Effectiveness Evidence hazard ratio highlight Hospital admissions Hospitalization ICU ICU admission immunization inactivated intensive care Lineage omicron outbreak pediatric population-based cohort Prevent Regression model SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe disease Support survival symptomatic the SARS-CoV-2 vaccination Vaccine [DOI] 10.1038/s41591-022-01874-4 [Article Type] Research
Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infectionSARS-CoV-2 감염 후 급성 심폐 증상에서 항체, 염증 표지자 및 심장초음파 소견의 역할Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Abnormalities age antibodies association baseline characteristics binding domain Biomarker Biomarkers breath C-reactive protein Cardiology Cardiopulmonary cardiovascular cardiovascular disease Cellular immune response chest pain COVID-19 cross-sectional analysis Dyspnea echocardiograms echocardiographic echocardiographic finding echocardiographic findings enrolled Evidence functional Hospitalization IgG antibody immune response individual Inflammation inflammatory markers investigation Logistic regression marker mechanism median median age occur palpitation palpitations parameter participant performed Receptor binding domain reported role SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 receptor Sex Shortness of breath Symptom Symptoms systemic inflammation women [DOI] 10.1172/jci.insight.157053 PMC 바로가기 [Article Type] Article
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severityT 세포 수용체 시퀀싱은 이전 SARS-CoV-2 감염을 식별하고 중화 항체 및 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-232022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive Biotechnologies Adaptive immunity antibody blood sample breadth conducted correlated COVID-19 Decline diagnostics difficulty breathing disease severity evaluated Fever Frederick greater Hospitalization humoral identify immune response Improved individual induce Infection Infectious disease initial less magnitude NAb neutralizing antibody NIAID protective immunity response SARS-CoV-2 SARS-COV-2 infection sensitivity Sequencing serology serology test severe disease significantly Society Support T cell T cell receptor T cell response T cell responses TCR transplantation Trial undetectable [DOI] 10.1172/jci.insight.150070 PMC 바로가기 [Article Type] Article
Changes in the Clinical Characteristics of Kawasaki Disease After Coronavirus Disease (COVID-19) Pandemic: A Database AnalysisObservational Study Published on 2022-05-232022-10-05 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval Admission Analysis analyzed average cardiac complication Cardiac complications change changes in children clinical Clinical characteristics Clinical course Complication complications coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnosed FIVE Hospital admission Hospitalization Infant investigated Kawasaki disease pandemic Patient proportion retrospective severity significant decrease significantly university hospital warehouse [DOI] 10.3346/jkms.2022.37.e141 PMC 바로가기 [Article Type] Observational Study
Risk of SARS-CoV-2 Breakthrough Infection in Vaccinated Cancer Patients: A Retrospective Cohort Study예방 접종을 받은 암 환자의 SARS-CoV-2 돌발 감염 위험: 후향적 코호트 연구Article Published on 2022-05-212022-09-11 Journal: Journal of Hematology & Oncology [Category] COVID19(2023년), SARS, 변종, [키워드] Breakthrough infection cancer patient Cancer patients COVID curated database death rate death rates determine dose Effectiveness Efficacy General population Height hematologic Hematologic malignancy higher risk Hospitalization malignancies malignancy Messenger RNA mRNA mRNA vaccine Multiple myeloma Myeloma oncology outcome Patient patient data remained Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection severe SARS Therapies therapy university vaccination Vaccine variant [DOI] 10.1186/s13045-022-01290-8 PMC 바로가기 [Article Type] Article
The Effectiveness of Pfizer-BioNTech and Oxford-AstraZeneca Vaccines to Prevent Severe COVID-19 in Costa Rica: Nationwide, Ecological Study of Hospitalization Prevalence코스타리카에서 심각한 COVID-19를 예방하기 위한 Pfizer-BioNTech 및 Oxford-AstraZeneca 백신의 효과: 입원 유병률에 대한 전국 생태학적 연구Observational Study Published on 2022-05-202022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] 95% CI Administered Analysis AstraZeneca Complete condition Costa Rica Costa Rican Coverage COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines declined delta variant detect determine dominant dose dose-dependent effective Effectiveness Epidemiology estimate evaluated first dose hospital Hospitalization hospitalizations Hospitalized information Intervention monitoring Observational observational study Older Older age outcome Oxford-AstraZeneca Pfizer-BioNTech Policy Prevalence Prevent prevention real-world second dose severity single dose Single-dose study period Surveillance vaccination Vaccination Status Vaccine Vaccines variant virus [DOI] 10.2196/35054 PMC 바로가기 [Article Type] Observational Study
Peak value of serum KL-6 may be useful for predicting poor prognosis of severe COVID-19 patients혈청 KL-6의 피크 값은 심각한 COVID-19 환자의 나쁜 예후를 예측하는 데 유용할 수 있습니다Observational Study Published on 2022-05-192022-09-11 Journal: European Journal of Medical Research [Category] MERS, 바이오마커, 임상, [키워드] 95% CI Accuracy adjusted odds ratio Admission age alveolar Analysis analyzed Area AUC baseline characteristics best Biomarker Biomarkers Comorbidities Concentration COVID-19 COVID-19 patient COVID-19 patients criteria cut-off value defined determine discrimination early phase epithelial evaluate examination help high risk high-flow oxygen therapy higher risk Hospitalization hospitalized patient identify inclusion criteria indicated initial Injury Invasive mechanical ventilation KL-6 LDH Logistic regression analyses minimum multivariate logistic regression non-survivor observational study once a week oxygen Oxygen therapy Patient patients peak performed Pneumonitis poor prognosis predict Prognosis Prognostic value progression reflect reported required Respiratory failure retrospective sensitivity serum severe COVID-19 patient Sex single-center supplemental oxygen survivor Treatment U/mL [DOI] 10.1186/s40001-022-00690-3 PMC 바로가기 [Article Type] Observational Study
Pearson’s patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreakResearch article Published on 2022-05-182022-10-05 Journal: iScience [Category] 바이오마커, 신약개발, 임상, [키워드] absence Admission Analysis Aspartate aminotransferase AST Clinical finding clinical parameter clinical risk Cohort conducted correlated COVID-19 outbreak death dysregulated Guidance Health Sciences healthcare Healthcare systems Hospitalization hospitalized patient independent initial lactate dehydrogenase LDH Mortality neutrophil neutrophil count Outbreaks outcome patients with COVID-19 retrospective cohort study risk factor targeted therapy with COVID-19 [DOI] 10.1016/j.isci.2022.104415 [Article Type] Research article
Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study기계 학습 기반 병원 내 COVID-19 질병 결과 예측기(CODOP) 개발 및 평가: 다대륙 후향적 연구Article Published on 2022-05-172022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] allocation AUROC breakthrough infections calibrated Clinical outcome clinical parameter clinical utility clinically Cohort cohort of patient Computational biology country COVID-19 COVID-19 disease COVID-19 patient deaths development disperse effective heterogeneous hospital Hospital admission hospital resources Hospitalization hospitalizations hospitalized COVID-19 patients Human In-hospital Latin Latin America machine-learning maintain Medicine New offer outcome pandemic patient cohort patient cohorts prediction Predictive Retrospective study risk stratification SARS-CoV-2 variants sensitivity Spain specificity Systems biology tested Triage USA vaccination vaccination rate Vaccination Status variant virus waning immunity [DOI] 10.7554/eLife.75985 PMC 바로가기 [Article Type] Article