Potential utilities of mask‐wearing and instant hand hygiene for fighting SARS‐CoV‐2Research Article Published on 2020-04-082022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] Aerosols approach caused coronavirus country COVID‐19 COVID‐19 Efficacy evaluated experiments hand hygiene hygiene Influenza virus literature review Mask medical masks medical system N95 masks Novel coronavirus pandemic Patient Potential previous study quantification SARS‐CoV‐2 Seven soap sodium Spread Support supported These data utility virus was performed [DOI] 10.1002/jmv.25805 PMC 바로가기 [Article Type] Research Article
Visualizing an unseen enemy; mobilizing structural biology to counter COVID-19 1Editorial Published on 2020-04-012022-10-27 Journal: Acta crystallographica. Section D [Category] Coronavirus, SARS, [키워드] Coronaviruses COVID-19 COVID-19 pandemic Crystallography editorial effective information researcher SARS-CoV-2 therapeutic agents These data Viral protein [DOI] 10.1107/S2059798320004830 PMC 바로가기 [Article Type] Editorial
Visualizing an unseen enemy; mobilizing structural biology to counter COVID-19 1Editorial Published on 2020-04-012022-10-28 Journal: Acta Crystallographica. Section F [Category] Coronavirus, SARS, [키워드] Coronaviruses COVID-19 COVID-19 pandemic Crystallography editorial effective information researcher SARS-CoV-2 therapeutic agents These data Viral protein [DOI] 10.1107/S2053230X20004847 PMC 바로가기 [Article Type] Editorial
Molecular docking and dynamics simulation of FDA approved drugs with the main protease from 2019 novel coronavirusResearch Article Published on 2020-03-312022-10-28 Journal: Bioinformation [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV azelastine binding binding pocket conivaptan docking drug dynamics simulation effective FDA approved drug feature hydrophobic interaction in vitro in vivo involved main protease maintain protease repurposing residues SARS-CoV sequence homology target protein These data [DOI] 10.6026/97320630016236 PMC 바로가기 [Article Type] Research Article
Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral ProteinsArticle Published on 2020-03-252022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV Antiviral caused Community coronavirus costly COVID-19 database develop functional Genomics Health information interactome knowledge molecular mechanism proportions protein-protein interactions rapid response Region Research SARS Coronavirus SARS-CoV-2 similarity structural genomics These data Vaccine viral infection virus [DOI] 10.3390/v12040360 PMC 바로가기 [Article Type] Article
The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion ConformationStructure and Assembly Published on 2019-09-182022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] alphacoronavirus spike antigens betacoronaviruses biological processe cause concerning conformation conformational Cryo-electron microscopy cryo-EM described domain effort epidemic diarrhea facilitate glycoprotein glycosylated heterogeneity high mortality rate High-resolution host cells host immune responses IMPROVE in viral Infection information Like macromolecular membrane fusion molecular mechanism N terminus Neonatal NL63 observation other coronaviruses pathogenic PEDV prefusion conformation Receptor binding receptor engagement Receptor-binding domain reveal S protein S1 subunit S1-CTD spike Spike protein Spike proteins Stage Structure subunit the S1 subunit the spike protein These data triggering trimer trimeric spike Vaccine Vaccines virus [DOI] 10.1128/JVI.00923-19 PMC 바로가기 [Article Type] Structure and Assembly
Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila세포질 비호환성의 Two-By-One 모델: 초파리에서 cifA 및 cifB의 형질전환 발현에 의한 합성 요약Research Article Published on 2019-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Bacteria caused comparable cytoplasmic Dengue dengue viruses Drosophila Drosophila melanogaster dual Embryo embryonic embryos expression female functional Gene expression analysis Genes Genetic genetic model hypothese hypotheses implication incompatibility induce infect infections kill lethality male mechanism methodology Modification phage Population predict Release Replication reported rescue rescued responsible robust Spread Strains Support synthetic These data transgenic uninfected vector control virus viruses wild type Wolbachia Zika [DOI] 10.1371/journal.pgen.1008221 PMC 바로가기 [Article Type] Research Article
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expressionResearch Article Published on 2019-05-162022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] abundantly expressed activity addition ADP-ribose ADP-ribosylation Affect antiviral activities Antiviral effect antiviral therapy cellular Coronaviridae coronavirus Coronavirus replication Critical disease enzyme expression facilitate host cell host response human cells identify IFN immune response in vivo independent inhibited inhibitor Innate immunity interferon knockdown less macrodomain Macrophage mice Modification monomer murine mutant mutant virus Mutation PARP PARP12 PARP14 PARPs pathogenic Polymer post-translational modification Prevent Protein Regulation Replication required significantly siRNAs target protein These data Togaviridae virulence virus virus infection virus replication Virus-host interaction viruses while wild-type wild-type virus [DOI] 10.1371/journal.ppat.1007756 PMC 바로가기 [Article Type] Research Article
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and AlpacasArticle Published on 2019-03-022022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] alpaca Camel Camels Complete disease Dromedary effective human infections humans humoral immune response interruption Lower MERS-CoV Middle East naïve nasal turbinate Neutralizing one health outbreak protection protein subunit vaccine reduce reduced respiratory risk robust Serum neutralizing antibody significantly spike These data upper airway vaccination Vaccines viral shedding zoonotic zoonotic transmission [DOI] 10.3390/v11030212 PMC 바로가기 [Article Type] Article