Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in miceN7-메틸트랜스퍼라제 활성이 결핍된 약독화 코로나바이러스 생백신은 마우스에서 체액성 및 세포성 면역 반응을 모두 유도합니다Original Article Published on 2021-08-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral approach Attenuated vaccines cap structure caused CD4 CD8 Cell culture Cellular immune response conserved coronavirus coronavirus vaccine Coronavirus vaccines Coronaviruses CoV COVID-19 pandemic CoVs Economy effective function guanine Health hosts humans humoral humoral immune response immune responses immunization induce infect Infection involved Live attenuated vaccine Live attenuated vaccines livestock MHV MHV-A59 mice murine hepatitis virus mutant N7-Methyltransferase nsp14 Protein provide replication efficiency respiratory RNA RNA virus robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus single dose T cell T cell responses the cell Treatment Vaccine variety Viral Viral RNA virus viruses wild-type [DOI] 10.1080/22221751.2021.1964385 PMC 바로가기 [Article Type] Original Article
mRNA Vaccines Enhance Neutralizing Immunity against SARS-CoV-2 Variants in Convalescent and ChAdOx1-Primed SubjectsArticle Published on 2021-08-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] B.1.351 BNT162b2 booster cellular ChAdOx1-nCoV-19 characterized Combination convalescent convalescent plasma COVID-19-convalescent individual Donor facilitate heterologous vaccination regimes using mRNA vaccines may allow enhanced protection against SARS-CoV-2, including current VOCs identify IFN-γ response immune responses immunization immunological protection Immunological response individual individuals investigated moderate mRNA mRNA vaccine mRNA-1273 Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing capacity Observational cohort study receiving required RNA vaccines may facilitate rapid (re-) qualification of convalescent plasma donors with high titers of broadly neutralizing antibodies SARS-CoV-2 serological significantly subject triggered vaccinated individual vaccination Vaccine variants of concern VOCs widespread [DOI] 10.3390/vaccines9080918 PMC 바로가기 [Article Type] Article
Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recoverySARS-CoV-2에 대한 체액 및 세포 면역 반응은 회복 후 최대 1년까지 지속됩니다.Article Published on 2021-08-172022-09-12 Journal: Nature Communications [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] Antimicrobial responses build cellular Cellular immune response Concentration convalescent stage Course COVID-19 Critical decrease effective Effectiveness Follow-up full-length hospital discharge humoral IgG level IgG levels immune protection immune response immune responses Immunity individual Kinetics neutralizing capacity Patient persistence protective immunity public health SARS-CoV-2 SARS-CoV-2 vaccination serum serum neutralizing capacity Spread Support the SARS-CoV-2 thought viral infection virus [DOI] 10.1038/s41467-021-25312-0 PMC 바로가기 [Article Type] Article
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern2회분의 SARS-CoV-2 백신 접종은 우려되는 새로운 SARS-CoV-2 변종에 대한 강력한 면역 반응을 유도합니다Article Published on 2021-08-172022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antimicrobial responses B.1.1.7 B.1.351 circulating Cohort conserved coronavirus dose epitope Epitopes generate high potency immune response immune responses immunization induce Infection Lineage magnitude majority natural infection neutralization Pathogens Pfizer Pfizer-BioNTech PROTECT prototype report required respiratory response robust SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 vaccination SARS-CoV-2 variant second dose second dose of vaccine severe acute respiratory syndrome Coronavirus single dose T cell T cell response T cells understanding vaccination Vaccine vaccine doses Vaccines variants variants of concern VoC [DOI] 10.1038/s41467-021-25167-5 PMC 바로가기 [Article Type] Article
Oral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection비강내 백신과 결합된 구강 박테리아는 인플루엔자 A 바이러스 및 SARS-CoV-2 감염으로부터 보호합니다Research Article Published on 2021-08-172022-09-12 Journal: mBio [Category] MERS, SARS, 신종인플루엔자, 진단, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant Administered administration Antibiotics Antibody Response Bacteria Bacterial bacterial pathogen Combined commensal bacteria coronavirus Critical demonstrated Disruption gut microbiota healthy immune responses Immunity induce Infection Influenza Influenza virus intranasal intranasal vaccine intranasally less lysozyme mucosal mucosal immunity mucosal surface MYD88 nasal oral oral cavity PAMPs pathogen-associated molecular pattern PROTECT SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly lower Vaccine Vaccines virus infection [DOI] 10.1128/mBio.01598-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2-Specific Antibody and T Cell Response Kinetics According to Symptom Severity증상 중증도에 따른 SARS-CoV-2-특이적 항체 및 T 세포 반응 역학Article Published on 2021-08-172022-09-12 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed antibody Antibody Response assays blood sample cell-mediated immune response collected Community convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient ELISA enrolled enzyme enzyme-linked immunospot evaluated greater groups hospital Human humoral IgG antibody IgG response IgM and IgG IgM antibodies IgM antibody immune responses interferon interferon-γ Kinetics Longevity Mild moderate not significantly different nucleoprotein overlapping Patient patients with COVID-19 peaked peptide peptides response SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses severe acute respiratory syndrome Coronavirus severe symptom severe symptoms severity significant difference significant differences significantly Spike protein Spike proteins symptom onset symptom severity T-cell Response Treatment waned were measured [DOI] 10.4269/ajtmh.20-1594 PMC 바로가기 [Article Type] Article
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questionsCOVID-19 회복기 혈장 기증자의 항체 지수: 답이 없는 질문Original Article Published on 2021-08-162022-09-12 Journal: Clinics [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response association candidate Care characterized Clinical characteristics clinical manifestation contagiousness convalescent COVID-19 patient convalescent plasma coronavirus correlated COVID-19 Diagnosis disease severity Evolution Health hypothese IgA IgG IgG antibody immune responses Immunity immunoglobulin A Infection Mild moderate neutralize not differ Patient polymerase chain positive presenting professional question raised SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe symptoms severity significantly significantly higher subject Symptom symptomatic Symptoms the antibody the disease viral clearance virus [DOI] 10.6061/clinics/2021/e2818 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in CellsMicrobiology Published on 2021-08-132022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Accessory accessory protein accessory protein ORF3a activated acute respiratory syndrome Apoptosis cells coronavirus expression HEK293T cell Host host immune responses IFN IFN signaling IFN-β IL-6 immune responses induce inhibitor innate immune responses Interaction interferon investigated IRF3 modulation Necrosis ORF6 ORF7b ORF8 pathogenicity Phosphorylation promoted Protein Regulatory reported SARS-CoV-2 signaling pathway TNF-α Transcription transcription factor Tumor VERO E6 cells virus–host interaction [DOI] 10.3389/fmicb.2021.654709 PMC 바로가기 [Article Type] Microbiology
Pathogenic Mechanisms of Vaccine-Induced Immune Thrombotic Thrombocytopenia in People Receiving Anti-COVID-19 Adenoviral-Based Vaccines: A Proposal항-COVID-19 아데노바이러스 기반 백신을 접종받는 사람들에서 백신 유도 면역 혈전성 혈소판 감소증의 병원성 기전: 제안Immunology Published on 2021-08-132022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 receptor activate adenoviral vectors administration affected amplify antibodies binding blood stream cell activation characterized Combination complexes component endothelia erythrocytes erytrocyte extracellular DNA favor heparin IL-6 immune immune response immune responses individual Infection Inflammatory injection leucocyte life-threatening mandatory mast cell Mast cells mechanism natural antibodies occur pathophysiological mechanism PF-4 PF4 Platelet platelet activation Platelets promote Protein receiving serum IgG spike Spike protein Spread Symptom syndrome thrombocytopenia thrombotic thrombotic event Thrombotic events Thrombotic thrombocytopenia Trigger triggering Vaccine Vaccines vector VITT [DOI] 10.3389/fimmu.2021.728513 PMC 바로가기 [Article Type] Immunology
Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: a randomized, double-blind, placebo-controlled, Phase I trial건강한 성인의 COVID-19에 대한 재조합 인터페론-무장 RBD 이량 체 백신 (V-01)의 안전성 및 면역 원성 : 무작위, 이중 맹검, 위약 대조, Phase I 시험Clinical Trial Published on 2021-08-122022-08-13 Journal: Emerging Microbes & Infections [Category] 임상, 진단, [키워드] adverse event AEs Anti-RBD IgG Antigen center China clinical trial clinical trials Control COVID-19 COVID-19 pandemic disease control Dose escalation double-blind effective vaccine Effective vaccines elderly participants elicited enrolled first dose fusion protein grade 3 Guangdong healthy humans IFN-PADRE-RBD-Fc dimer immune responses immunogenicity induce initiated intramuscularly low dose Neutralizing antibodies neutralizing antibody PADRE Participants peaked phase Phase I Placebo placebo-controlled preliminary finding prevention progression protective immunity Randomized Randomly RBD dimer RBD IgG receive recombinant COVID-19 vaccine recombinant protein vaccine Safe Safety safety profile SARS-CoV-2 subgroup supported the vaccine Trial V-01 Vaccine [DOI] 10.1080/22221751.2021.1951126 PMC 바로가기 [Article Type] Clinical Trial