These data – Page 61 – Communicable Diseases Research

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다

Research Article

Published on 2019-02-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activation

Research Paper

Published on 2018-10-292022-10-28
Journal: Virulence [Category] Coronavirus,

[키워드] activated activating acute enteritis Affect Amino acid amino acid residue bovine cause caused Cell contribute Critical Culture demonstrated domain down-regulation Eagle epithelial cell line exhibited expression fetal gastroenteritis indicated individual Infection infections Inflammation Inflammatory response inhibitor intestinal intestinal inflammation involved IκB monoclonal Necrosis NF-κB NF-κB NF-κB activation nitric oxide NSP2 nuclear p65 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines Protein Regulation Replication reporter reverse transcription significantly suggested TGEV These data tissue transcription factor transmissible gastroenteritis virus Viral protein virus
[DOI] 10.1080/21505594.2018.1536632 PMC 바로가기 [Article Type] Research Paper

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Research Article

Published on 2018-10-092022-10-29
Journal: mBio [Category] Coronavirus,

[키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss
[DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article

Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network

비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다

Research Article

Published on 2018-06-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers
[DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses

Research Article

Published on 2018-05-012022-10-29
Journal: mBio [Category] Coronavirus, MERS,

[키워드] absence antibodies Betacoronavirus caused cellular coronavirus CoV CoVs cultured cells Effect genomic genomic RNA gRNA IFN IFNAR in viral in vitro in vivo increases in Infection innate immune innate immune response innate immune system interferon interferon response interferon signaling locus marrow-derived macrophage MAVS mechanism MHV mice murine hepatitis virus mutant mutant virus Mutation not affect Nsp15 ORF1b packaged packaging signal Pathogenesis pathogenicity positive positive-sense promote receptor reduced remained replicated Replication required response restored RNA RNA molecule RNA packaging RNAs selective selective packaging significantly strain subgenomic RNAs These data TLR7 treated Type virion virions virulence virus virus replication viruses weight loss
[DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article

MERS-CoV spillover at the camel-human interface

Research Article

Published on 2018-01-162022-10-31
Journal: eLife [Category] Coronavirus, Fulltext, 조류인플루엔자,

[키워드] Analysis approach Arabian Peninsula caused Cluster common cold Complete Contact coronavirus demonstrated distribution driven by effort Endemic Epidemic Epidemiology Evidence Evolution example Genome group hospital Host host tropism hosts Human humans Hypothesis illnesses Infection introduced mapped MERS MERS coronavirus MERS-CoV Middle East mitigate morbidity Mortality New coronavirus occur occurred outbreak Outbreaks Patient phylodynamics phylogenetics Pneumonia Population reconstructed respiratory syndrome coronavirus SARS Coronavirus sequence sequenced sequenced genomes severe respiratory symptom Spread structured coalescent Support syndrome the epidemic These data transfer unlikely utilised virus was collected widespread zoonosis zoonotic Zoonotic introduction
[DOI] 10.7554/eLife.31257 PMC 바로가기 [Article Type] Research Article

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

Research Article

Published on 2017-11-152022-11-01
Journal: Science Advances [Category] Coronavirus, MERS,

[키워드] Acidic alternative route basolateral Caco-2 cell caused cells demonstrated effective epidemiological epithelial Evidence Fatality rate histological examination Human human DPP4 human gastrointestinal tract Infection Infection route Inflammation inhibitor inoculated intestinal epithelial cells intestinal organoid intestinal tract less lethal infection Live virus lung tissues MERS-CoV MERS-CoV infection mice Middle East Patient progression respiratory infection respiratory syndrome coronavirus robust shown small intestine small intestines specimen Stool susceptible These data transgenic mice viral replication virological study virus transmission
[DOI] 10.1126/sciadv.aao4966 PMC 바로가기 [Article Type] Research Article

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall
[DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation

항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증

Research Article

Published on 2016-09-072022-09-17
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray
[DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다

Research Article

Published on 2016-07-222022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence
[DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article