Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatientsMeta-Analysis Published on 2022-05-112022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 임상, 치료법, [키워드] 95%CI Administered Analysis antibodies clinical clinical trial Comorbidity convalescent plasma COVID-19 outpatient death decrease died disease severity double-blind Endpoint Evidence favor highest Hospital admission Hospitalization Hospitalized IgG Intervention mechanical ventilation median age Meta-analysis multicenter Odds ratio Outpatient outpatients Patient patient data polyclonal progression Prospective Randomized controlled trials randomized trial recruitment reduced required risk SARS-CoV-2 suggested Symptom symptom resolution symptomatic Symptoms the disease therapeutic potential Treatment viral infection [DOI] 10.1038/s41467-022-29911-3 PMC 바로가기 [Article Type] Meta-Analysis
Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 2019 coronavirus disease 95% CI age Antibody titer Antibody titers AUC baseline Biochemistry characteristic Cohort cohort study collected COVID-19 COVID-19 infection demographics downloaded Factor Factors Hospitalization host immunity Human Cytomegalovirus immune markers Infectious disease Linear Discriminant Analysis lipids Metrics Model participant pathogen predict profile public health risk risk factor sensitivity serology Severe infection severity specificity subset threshold UK biobank was used [DOI] 10.1038/s41598-022-07307-z [Article Type] Research
Survival analysis of COVID-19 patients in Ethiopia: A hospital-based studyObservational Study Published on 2022-05-092022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] Admission admitted to ICU age analyzed Care carried chronic chronic kidney diseases chronic obstructive Clinical characteristics close monitoring confidence COVID-19 COVID-19 case COVID-19 disease COVID-19 patient Cox regression analysis death deaths Final global public health hazard high mortality higher risk HIV/AIDS Hospitalization Hospitalized hospitalized patient independent risk factor interval intranasal Kidney disease laboratory-confirmed majority median medical record Mortality mortality rate nine Observational cohort study occurred Older oxygen Patient patients hospitalized performed predictor Probability pulmonary disease Ratio retrospective risk risk of death Sociodemographic survival survival analysis the patient those with comorbidity treated Treatment zone [DOI] 10.1371/journal.pone.0268280 PMC 바로가기 [Article Type] Observational Study
Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic델타 변이형 대유행 기간 동안 경증에서 중등도의 코로나바이러스 질환 환자를 대상으로 한 카시리비맙-임데비맙 치료의 실제 임상 결과Article Published on 2022-05-092022-09-11 Journal: International Journal of Medical Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission body temperature Casirivimab casirivimab-imdevimab cigarette smoking clinical Clinical deterioration Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Delta delta variant demonstrated Deterioration dyslipidemia Effectiveness Efficacy enrolled evaluated Fukushima greater hospital Hospitalization hypertension Imdevimab independent Japan Logistic regression analysis Mild-to-moderate monoclonal antibody monoclonal antibody therapy multivariate multivariate logistic regression analysis Neutralizing obesity Odds ratio Older pandemic Patient Propensity score real-world effectiveness. receiving reduce respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus significantly lower smoking therapy Treatment [DOI] 10.7150/ijms.71132 PMC 바로가기 [Article Type] Article
Clinical course and outcomes of COVID-19 patients with chronic obstructive pulmonary disease: A retrospective observational study in Wuhan, ChinaObservational Study Published on 2022-05-062022-10-05 Journal: Medicine [Category] 임상, [키워드] acute exacerbation Admission age age and sex Analysis analyzed China chronic obstructive clinical Clinical course Clinical outcome clinical outcomes Comorbidity COPD coronavirus disease correlated Course COVID-19 COVID-19 patient Cox regression death diagnosis of COVID-19 Dyspnea exhibited Hospitalization Huoshenshan Hospital Infection Inflammation Inflammatory responses Injury intensive care Kaplan-Meier Laboratory test mechanical ventilation outcome pathophysiology Patient performed proportion pulmonary disease Randomly regression analysis Respiratory failure respiratory tract retrospective Retrospective study selected severe COVID-19 subsequent two groups viral clearance was performed Wuhan Wuhan, China [DOI] 10.1097/MD.0000000000029141 PMC 바로가기 [Article Type] Observational Study
The balancing role of distribution speed against varying efficacy levels of COVID-19 vaccines under variants변종에 따른 COVID-19 백신의 다양한 효능 수준에 대한 유통 속도의 균형 역할Article Published on 2022-05-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accessibility adverse outcome adverse outcomes attack rate caused COVID-19 COVID-19 pandemic COVID-19 vaccine deaths distribution Effectiveness Efficacy evaluated example Hospitalization hospitalizations immunization Infection initial Interaction key factor Mutation occurred pandemic public health raised reduce reducing regions SARS-CoV-2 speed Spread the vaccine understanding vaccination Vaccine variant variants [DOI] 10.1038/s41598-022-11060-8 PMC 바로가기 [Article Type] Article
Effect of Early Treatment with Ivermectin among Patients with Covid-19Covid-19 환자에서 Ivermectin의 조기 치료 효과Randomized Controlled Trial Published on 2022-05-052022-09-25 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, [키워드] acute respiratory syndrome Adaptive platform trial Admission adverse events Analysis assigned Bayesian credible interval Brazil caused clinics conducted coronavirus coronavirus disease defined Disease progression dose double-blind early diagnosis Effect Efficacy events finding hospital Hospital admissions Hospitalization incidence Intervention involved Ivermectin ivermectin group modified intention-to-treat no significant effect observation outcome Outpatient Patient patients per-protocol analysis Placebo placebo-controlled primary analysis progression public health randomization Randomized Randomly receive recruited regimen reported risk risk factor SARS-CoV-2 secondary outcome Symptom symptomatic the disease the placebo group Trial worsening [DOI] 10.1056/NEJMoa2115869 PMC 바로가기 [Article Type] Randomized Controlled Trial
Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California남부 캘리포니아의 2020-2021년 겨울 서지 동안 단일 대형 의료 시스템에서 게놈 감시에 의한 SARS-CoV-2 엡실론 변이체 및 입원 상태 조사Article Published on 2022-05-042022-09-11 Journal: American journal of clinical pathology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission B.1.427 B.1.429 California collected coronavirus COVID-19 Epsilon Epsilon variant frequencies Frequency genomic Genomic surveillance health system Hospitalization hospitalized patients ICU ICU admission ICU patient ICU Patients intensive care intensive care unit investigation outpatients patients respiratory sample Respiratory samples SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease status Surveillance System unique variant virulent was performed Winter [DOI] 10.1093/ajcp/aqab203 PMC 바로가기 [Article Type] Article
Genetic Landscape of the ACE2 Coronavirus ReceptorACE2 코로나바이러스 수용체의 유전적 지형Meta-Analysis Published on 2022-05-032022-09-11 Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases [DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis
Comparative effectiveness over time of the mRNA-1273 (Moderna) vaccine and the BNT162b2 (Pfizer-BioNTech) vaccine Research Published on 2022-05-022022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI age Analysis BNT162b2 BNT162b2 vaccine Comparative conducted database Diagnosis Effectiveness follow-up period Hospitalization ICU admission immunization incidence individual Infection Medicare Moderna mRNA-1273 mRNA-1273 vaccine no difference Pfizer-BioNTech post vaccination Primary outcome provide Research retrospective cohort study SARS-COV-2 infection second dose Separate statistical significance transfer vaccinate vaccinated individuals Vaccine Vaccines [DOI] 10.1038/s41467-022-30059-3 [Article Type] Research