Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study경증에서 중등도의 COVID-19 환자에서 항-CD3 단일클론항체(Foralumab)의 비강 투여로 폐 염증 및 혈액 염증 바이오마커 감소: 파일럿 연구Immunology Published on 2021-08-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 진단, [키워드] administration animal model animal models anti-CD3 Autoimmunity benefit Brazil C-reactive protein Chest CT clearance Control COVID-19 COVID-19 disease COVID-19 infection determine Dexa Dexamethasone disease downregulate Effect foralumab hyperactivity IL-6 immune immune response immune responses immunomodulatory properties immunomodulatory property lung lung infiltrate lung infiltrates lung involvement medication Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 monoclonal antibody morbidity morbidity and mortality nasal Outpatient Patient performed pilot study Randomized receive recruited reduction Result SARS-CoV-2 serum Serum IL-6 severe adverse events Standard of care state subject treated treated patients Treatment [DOI] 10.3389/fimmu.2021.709861 PMC 바로가기 [Article Type] Immunology
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2이전에 SARS-CoV-2에 감염된 의료 종사자의 ChAdOx1 nCoV-19 백신 1회 투여 후 항체 반응Research paper Published on 2021-08-122022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] (ChAdOx1 nCoV-19 Adenovirus-vectored vaccine Administered antibody Antibody Response blocking antibodies BNT162b2 BNT162b2 vaccine booster ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine contributed Delta dose effective expressing finding funding healthcare worker immune immune response immune responses individual infected with SARS-CoV-2 less Lineage Messenger RNA mild SARS-CoV-2 infection mRNA mRNA vaccine naïve Neutralizing antibodies neutralizing antibody Neutralizing antibody response of BNT162b2 participant post infection Post-vaccine Preexisting immunity Prior infection provide RBD-ACE2 RBD-specific IgG receiving recent regimen robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein serological response single dose Spike protein Support the SARS-CoV-2 two-dose regimen vaccination Vaccine variants variants of concern vectored vaccine wild type [DOI] 10.1016/j.ebiom.2021.103523 PMC 바로가기 [Article Type] Research paper
COVID-19 Vaccines in Patients with Maintenance HemodialysisReview Published on 2021-08-122022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] addition age Analysis anti-SARS-CoV-2 antibody antibody Antibody detection antibody formation Antibody Response caused Comorbidities concerning contagious COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination COVID-19 vaccines death dialysis disease dosage Effectiveness elicited Factors General population greater healthy control Hemodialysis hygiene immune response immune responses Immunity immunization immunosuppressive Infection information Isolation maintenance Measures Older age Patient populations Protective receiving remains uncertain repeated risk of COVID-19 serum albumin social distancing therapy timepoints vaccination Vaccine Vaccine development Vaccines [DOI] 10.3390/jpm11080789 PMC 바로가기 [Article Type] Review
Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화Brief Report Published on 2021-08-112022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19 [DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19시리아 햄스터의 시간적 omics 분석은 중간 정도의 COVID-19에 대한 세포 효과기 반응을 풉니다.Article Published on 2021-08-112022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] Adaptive immunity alterations Analysis Anti-viral blood sample Blood samples Cell cellular cellular mechanism cellular mechanisms Cellular responses COVID-19 COVID-19 patients COVID19 Cytotoxic T cell Cytotoxic T cells dataset datasets disease severity Endothelial cell endothelial cells epithelial cell epithelial cells Evidence expression functions Genes hamster identify IgM antibodies IgM antibody immune response immune responses Infection inflammatory lung injury Innate immunity longitudinal analysis lung Lung injury Lungs Macrophage macrophages Mechanisms of disease Moderate COVID-19 monocyte Monocyte-derived macrophages Pathomechanism Pathomechanisms post infection pro-inflammatory Pro-inflammatory genes proteomics response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Subtypes T cell T cells Temporal Therapeutic strategies transcriptional response Viral viral clearance viral infection [DOI] 10.1038/s41467-021-25030-7 PMC 바로가기 [Article Type] Article
Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms급성 후 증상이 있거나 없는 COVID-19에서 회복하는 개인의 장기 SARS-CoV-2 특이적 면역 및 염증 반응Article Published on 2021-08-102022-09-11 Journal: Cell Reports [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody levels CD107a CD4 CD8 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 degranulation expressing Frequency immune immune response immune responses Immunity individual Infection Inflammation Inflammatory response initial Long COVID Lung disease magnitude marker neutralization capacity observé participant PASC PCR-confirmed peptide peptide pool Post-acute sequelae of SARS-CoV-2 infection recovering from COVID-19 respiratory Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity Spectrum Symptom symptom onset T cell T cell response T cell responses T cells Viral viral shedding [DOI] 10.1016/j.celrep.2021.109518 PMC 바로가기 [Article Type] Article
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal studyCovid-19 코호트 (IMPACC)에서의 면역 표현형 평가 : 전향 적 종단 연구Multicenter Study Published on 2021-08-102022-09-10 Journal: Science Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] analyses assays assessment biologic Biomarker Biomarkers Blood clinical Clinical and laboratory data clinical criteria Course COVID-19 COVID-19 cohort description Disease progression effective feature generate genomic harmonization hospitalized patient hospitalized patients Host immune response host immune responses hypothese hypotheses identify immune responses Immunophenotyping Laboratory laboratory data longitudinal study manifestation metabolomic multicenter multisite pathogen processing proteomic protocol protocols Radiographic recruitment respiratory secretion severity Study design susceptibility with COVID-19 [DOI] 10.1126/sciimmunol.abf3733 PMC 바로가기 [Article Type] Multicenter Study
Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand태국의 COVID-19 환자에서 SARS-COV-2의 재조합 수용체-결합 단백질 (RBD)에 대한 항체 반응의 클래스 및 서브 클래스를 특성화하기위한 종단 분석Research Article Published on 2021-08-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme antibody Antibody assays Antibody Response Antibody responses contribute convalescent sera convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients Dengue fever detect domain ELISA ELISAs febrile healthy individual healthy individuals highest Host Human human immune response IgA IgG IgG level IgG levels IgG subclasse IgG subclasses IgG1 IgG3 IgM immune responses Infection Influenza Interpretation investigated leptospirosis longitudinal median molecular assays murine murine typhus natural infection ORF1ab ORF1ab gene outbreak Patient patients patients with COVID-19 Protein RBD RBD antigen reactivity respiratory RT-PCR SARS-CoV-2 SARS-COV-2 infection sera serological assays serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly higher Spike protein target tested Therapeutics tropical typhus Viral Viral detection viral spike protein [DOI] 10.1371/journal.pone.0255796 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 A phase 1 randomized clinical trialSARS-COV-2에 대한 mRNA- 지질 나노 입자 백신 후보의 안전성 및 면역 원성은 1 상 무작위 임상 시험Clinical Trial Published on 2021-08-102022-08-13 Journal: Wiener Klinische Wochenschrift [Category] MERS, SARS, 임상, 진단, [키워드] Belgium comparable convalescent sera CureVac CVnCoV CVnCoV dose CVnCoV doses CVnCoV vaccination dosage Dosage-dependent increases Dose-response elicited ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Escalation Frequency Germany Ghent group Hannover healthy IgG antibodies IgG antibody immune response immune responses immunogenicity increases in interim analysis intramuscular dose Lipid nanoparticle Lipid nanoparticles LNP Local local AEs Mild moderate Munich Neutralizing antibodies overlapped Phase 1 phase 1 study Placebo platform Protein randomized clinical trial RBD reactogenicity Receptor binding domain response Result S protein S‑protein Safe Safety SARS-CoV-2 SARS-CoV‑2 SARS-CoV‑2 neutralizing titer SARS-CoV‑2 neutralizing titers SARS-CoV‑2 S‑protein second dose sequence-optimized mRNA coding serious AEs seroconverted severity supplementary material systemic adverse event systemic adverse events systemic AEs Tübingen vaccination Vaccine vaccine candidate Volunteer was measured [DOI] 10.1007/s00508-021-01922-y PMC 바로가기 [Article Type] Clinical Trial
Harnessing immunological targets for COVID-19 immunotherapyReview Published on 2021-08-092022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] antibodies caused Cell contagious COVID-19 COVID-19 vaccine Cytokine storm develop disease help host immune system Immune cell immune response immune responses immunological Immunotherapy Innate Innate immunity Liposome long-lasting microbial infection molecular mRNA Novel coronavirus Protective protective immunity SARS-CoV-2 stimulate T-cell target viral infection viruses [DOI] 10.2217/fvl-2021-0048 PMC 바로가기 [Article Type] Review