A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to NeuroinflammationT 세포 수용체 신호 분자 Vav1의 천연 변이체는 이펙터 T 세포 기능과 신경 염증에 대한 감수성을 모두 감소시킵니다Research Article Published on 2016-07-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Affect alteration Antigen antigen receptor Autoimmune candidate gene CD4 T cell CD4 T cells changes in chromosome 9 Control cytokine cytokine production Cytokines Diseases effector effector T cell effector T cells FOXP3 function functions Genetic genetic study GM-CSF guanine highlight IFN-γ IL-17 immune system immunization Inflammatory cytokine Inflammatory cytokines intrinsic leads locus mechanism mice MOG molecule natural Neuroinflammation Non-synonymous normal enzymatic activity nucleotide peptide phenotype physiological polymorphism Polymorphisms proportion Quantitative receptor reduce reduced Regulatory T cell regulatory T cells Signaling susceptibility T cell T cell receptor T cells Th1/Th17 These data transducing Treg variant Vav1 [DOI] 10.1371/journal.pgen.1006185 PMC 바로가기 [Article Type] Research Article
A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive보존된 DNA 반복은 게놈 아카이브에서 트리파노소마 브루세이 표면 항원의 다양한 레퍼토리 선택을 촉진합니다Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated addition African African trypanosomiasis antigenic variation archive assumption bloodstream catastrophic Cell cell cycle Chromosomal translocation Chromosomal translocations chromosome chronic condition conserved demonstrated DNA DNA sequence Donor event expression gene conversion genetic change Genome genomic homolog homology Host Hypothesis identify implicated induce infect Infection iteration mammalian manipulation natural infection observation observé outcome parasite pathogen Pathogens promote Protein proximal Recombination recombination event reduction in Region Repeat repertoire required selected Selection sequence silent species Support surface Surface glycoprotein switching synthetic tested the cell These data transcribed translocation Trypanosoma Trypanosoma brucei Trypanosome trypanosomiasis Variant Surface Glycoprotein VSG [DOI] 10.1371/journal.pgen.1005994 PMC 바로가기 [Article Type] Research Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial CellsResearch Article Published on 2016-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] A549 cell A549 cells addition Affect antiviral activity antiviral response Cell cellular chloride coronavirus 229E decrease decreased expression deficiency diminished downstream DPI dysregulated expression G6PD glucose-6-phosphate dehydrogenase homeostasis Impaired Infection Inflammatory response inhibitor MAPK NADPH NADPH oxidase NF-κB occurred oxidative stress PGE Phosphorylation provide reduced reducing Regulation response Signaling subunit susceptibility These data TNF-α transcriptional level Treatment tumor necrosis factor-α up-regulated viral infections viral replication was determined [DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
Inactivation and safety testing of Middle East Respiratory Syndrome CoronavirusArticle Published on 2015-07-172022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] acetone biosafety BSL BSL-2 BSL-3 buffer caused CDC Cell culture center Complete Contact Control coronavirus Culture deaths dose East effective evaluate evaluated Evidence experimental work fixation handling Human human infection human-to-human transmission inactivation irradiation Laboratory MERS-CoV MERS-CoV infected cell methanol middle Middle East other coronaviruses prevention protocol reagent required respiratory RNA specimen Standard cell These data Transmission virus [DOI] 10.1016/j.jviromet.2015.07.002 PMC 바로가기 [Article Type] Article
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast [DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article
Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection녹농균 급성 화상 및 만성 외과적 상처 감염에 대한 요건Research Article Published on 2014-07-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major accompanied acute and chronic infections acute and chronic P. aeruginosa wound infections acute and non-diabetic chronic wound infections acute burn wound infections acute infection acute infections acute wounds addition amino acids Bacterial bed sores Burn burn wound burn wound infections burns carbon carbon source caused chemotactic chemotaxis chronic chronic and acute wounds chronic infection chronic infections chronic wound chronic wound infections cofactor cofactors colonization complex Critical determinant diabetic ulcers energy expression Fatty acid fatty acids fitness flagellar function Gene Expression Gene expression profiling Genetic genomic growth healthcare high mortality High-throughput sequencing in vivo Infection infections insertion Intensive Intervention metabolic genes murine model murine models mutant non-diabetic chronic wound infection non-diabetic chronic wound infections not correlated nutritional requirements opportunistic infection opportunistic Infections opportunistic pathogen P. aeruginosa P. aeruginosa wound infections pathogen Pathogenesis persistence power primary source profiles Pseudomonas aeruginosa purines Requirement RNA-Seq Sepsis Sequencing Soft tissue Soft tissue infections Spread Strains Surgical Wound Infection These data tissue damage Tn-seq trajectory Transcriptome Travel utility Variation virulence while Wound Infection wound infections [DOI] 10.1371/journal.pgen.1004518 PMC 바로가기 [Article Type] Research Article
A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum플라스모듐 팔시파룸(Plasmodium falciparum)에서 변경된 퀴닌 및 퀴니딘 반응에 대한 새로운 후보 유전자로서의 HECT 유비퀴틴-단백질 리가제Research Article Published on 2014-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Altered Analysis antimalarial antimalarial drug Asia association candidate candidate gene changes in chromosome chromosome 13 complex conducted contribute contributing to cross cytotoxic activity defend demonstrated drug Efficacy experiment Factor Factors Genetic genetic screens genetic trait identify IMPROVE initial isolate Laboratory Ligase likelihood locus malaria malaria parasite moderate multiple allele multiple alleles mutated novel occur P. falciparum Plasmodium falciparum preservation progeny Quantitative quantitative trait locus quinidine Quinine response responsiveness segment sensitivity strain subset Surveillance susceptibility These data Treatment treatment failure ubiquitin ligase [DOI] 10.1371/journal.pgen.1004382 PMC 바로가기 [Article Type] Research Article
Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic RegionsPrion 균주의 광범위한 다양성은 차등 샤페론 상호 작용 및 고유한 아밀로이드 생성 영역에 의해 정의됩니다Research Article Published on 2014-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregates aggregation amyloid Analysis canonical chaperone cofactor cofactors complex conformation conformational conformational change consequence Critical determinant disease disease pathology Disease progression Diseases disorders Diversity domain element examined Extensive Factor help Host Hypothesis induce Interaction involved manifestation modulating molecular neurodegenerative pathology phenotypic phenotypic variation prion progression Propagation Protein Proteins provided PSI Region responsible stability strain Strains structures Support These data Transmission unique Variability variant variants Variation variety widespread yeast [DOI] 10.1371/journal.pgen.1004337 PMC 바로가기 [Article Type] Research Article
Analysis of the Host Transcriptome from Demyelinating Spinal Cord of Murine Coronavirus-Infected MiceResearch Article Published on 2013-09-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accompanied accompany Antigen presentation approach Central nervous system changes in CNS contribute CORD cytokine DAP12 debris clearance demyelinating Demyelination disease Diseases Evidence expression Factor found Gene High-throughput sequencing highlight Host host antiviral response host transcriptome immune infiltration Immune-mediated increased expression induce Infected Infection Inflammation information involved knowledge lipid metabolism lipid transport Macrophage MHV microglia mouse hepatitis virus multiple sclerosis neurodegenerative pathway persistent infection RNA-Seq several gene spinal Support These data transcriptional change TREM2 upregulated viral infection [DOI] 10.1371/journal.pone.0075346 PMC 바로가기 [Article Type] Research Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article