Silence of the Lambs: The Immunological and Molecular Mechanisms of COVID-19 in Children in Comparison with AdultsReview Published on 2021-02-072022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory syndrome Admission Adults alteration Analysis analyzed Antigen Asymptomatic children clinical condition clinical manifestation coronavirus COVID-19 death defined develop diffusion disease effective explain Hospitalization Host immune response immune system immunological infected children Infection Innate immunity intensive care knowledge literature measure mechanism of action Mild MIS-C molecular mechanism pediatric repeated SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease severe COVID-19 severity of COVID-19 silence susceptibility therapeutic understanding Variation virus [DOI] 10.3390/microorganisms9020330 PMC 바로가기 [Article Type] Review
Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A VirusArticle Published on 2021-02-032022-10-28 Journal: Viruses [Category] COVID-19, 신종인플루엔자, [키워드] acute infections addition Antiviral antiviral response ATPase block broad-spectrum common cold coronavirus coronavirus coronavirus OC43 COVID-19 vaccine derivatives disease effective Effective vaccines H1N1 Host Human immortalized include induce Infection influenza A virus Influenza virus inhibit inhibitor inhibitory innate immune Innate immunity Major mice mouse OC43 oseltamivir primary human cells Remdesivir Replication respiratory respiratory syncytial virus respiratory virus ribavirin RSV SARS-CoV-2 significantly thapsigargin treat vaccination virus [DOI] 10.3390/v13020234 PMC 바로가기 [Article Type] Article
COVID-19 vaccines: where we stand and challenges aheadCOVID-19 백신: 우리가 서 있는 곳과 앞으로 도전하는 곳Review Published on 2021-02-012022-09-11 Journal: Cell Death and Differentiation [Category] 변종, 임상, 치료제, [키워드] adopted approved BCG clinical evaluation clinical trials COVID-19 dose doses effort elapsed Emergency use exceptional Genome group human population Immunity immunological individual Innate immunity over pandemic phase Phase III clinical trials platform positive problem reducing SARS-CoV-2 SARS-CoV-2 virus Scientific community Spread subject the SARS-CoV-2 virus Vaccine vaccine candidate Viral Viral variants [DOI] 10.1038/s41418-020-00720-9 PMC 바로가기 [Article Type] Review
The COVID-19 immune landscape is dynamically and reversibly correlated with disease severityClinical Trial Published on 2021-02-012022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] acute COVID-19 Adaptive immune response Adaptive immunity alteration Analysis Clinical improvement Clusters Cohort coronavirus disease correlated Course COVID-19 critically ill patients Cytometry disease disease severity dominant dysregulated immune response family feature foundation hospitalized COVID-19 identify IL-6 pathway immune immune correlate immune response Immunity individual Innate Innate immunity Intervention Leonard longitudinal Mild moderate disease outcome Patient presenting SARS-CoV-2 severe COVID-19 severe disease specimen trajectory were used [DOI] 10.1172/JCI143648 PMC 바로가기 [Article Type] Clinical Trial
Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine ImmunizationReview Published on 2021-01-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] addition amelioration of disease contribute current disease effective vaccine facilitate Factors Genetic immune correlate immune responses Immunity induce Infection innate immune Innate immunity Local lower risk mucosal mucosal immunity neutralizing antibody Neutralizing antibody titer Potential protection robust SARS-CoV-2 SARS-COV-2 infection severity suggested sustained T-cell immunity Th1 response Th1 responses trained immunity type I interferon type I interferons Vaccine Viral transmission [DOI] 10.3390/pathogens10020138 PMC 바로가기 [Article Type] Review
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across speciesCoronaviruses Published on 2021-01-292022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] 3CLpro cleavage cleave cleaved cleaving contribute COVID-19 COVID-19 patients Critical cytokine Direct disease ENCODE example explain function Genome homolog Host IFN response implication in-vitro assay inflammatory pathway Inflammatory response innate immune response Innate immunity involved IRF3 lack mediated cleavage molecular mechanism motif NLRP12 NSP3 (PLpro) nsp5 NSP5 (3CLpro) pathophysiology PLPro polyprotein protease Protease activity Protein Replication responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protease TAB1 [DOI] 10.1080/22221751.2020.1870414 PMC 바로가기 [Article Type] Coronaviruses
Cannabinoids as Key Regulators of Inflammasome Signaling: A Current PerspectiveInflammasome 신호 전달의 주요 조절자로서의 칸나비노이드: 현재의 관점Review Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, 치료제, [키워드] activated Anti-inflammatory cannabidiol cannabinoid cannabinoids cannabis caspase caspase-1 chronic inflammatory diseases chronic inflammatory disorder chronic inflammatory disorders concerning coronavirus coronavirus disease COVID-19 current Cytokines cytoplasmic Delta-9 tetrahydrocannabinol detect drug elements etiology Evidence human disease human diseases human disorder IL-18 indicate Inflammasome inflammasome activation inflammasome signaling inflammasomes Inflammatory Inflammatory diseases inflammatory disorders inflammatory signaling ingredient Innate immunity interleukin marijuana maturation mechanism Medical conditions microbial milieu modulating pandemic pathophysiology plant pro-inflammatory cytokines promote protein complex protein complexes pyroptosis referred to Regulation regulator Research secretion Support tetrahydrocannabinol Treatment variety [DOI] 10.3389/fimmu.2020.613613 PMC 바로가기 [Article Type] Review
Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylationReview Published on 2021-01-262022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Activation antagonized Antiviral antiviral responses cellular coronavirus COVID-19 pandemic DNA viruses DUB dysregulation enzyme evade Evidence immune evasion include innate immune response Innate immunity interferon ISG15 knowledge mechanism Pathogenesis pathway post-translational modification Protein regulate Regulation RIG-I-like receptor RLRs RNA virus SARS-CoV-2 Signaling turn type I interferon ubiquitin upregulation Vaccines viral evasion viral pathogen virus infection [DOI] 10.3390/v13020182 PMC 바로가기 [Article Type] Review
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages기관지폐포 세척액의 선천적 및 적응 면역 단일 세포 프로파일링을 통해 심각한 COVID-19와 경증 구별Article Published on 2021-01-212022-09-12 Journal: Cell Research [Category] 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] adaptive Alveolar macrophages Anti-inflammatory BAL bioinformatics Bronchoalveolar lavage build CD4 CD8 Cell change Characteristics characterized clearance contribute COVID-19 Critical Evidence expressing fibrosis functions Gene Expression Genome-wide analysis of gene expression host immune system Hyperinflammatory immune immunopathology in viral Innate immunity involved lung Lung epithelial cells Macrophage marker Mild monocyte naïve neutrophil Non-COVID-19 Patient Pneumonia proportion reveal single-cell Stress T-cell Trajectories trajectory undergo vice [DOI] 10.1038/s41422-020-00455-9 PMC 바로가기 [Article Type] Article
Enterovirus D68 molecular and cellular biology and pathogenesisJBC Reviews Published on 2021-01-212022-10-04 Journal: The Journal of Biological Chemistry [Category] 비임상, [키워드] accumulating acute flaccid myelitis Adaptive immunity AFM AFM, acute flaccid myelitis antigens cascade CDC, US Centers for Disease Control and Prevention cellular change changes in children contribute COVID-19, Coronavirus disease 2019 eIF4, eukaryotic initiation factor 4 EMG, electromyography study enterovirus Enterovirus D68 Epidemiology EV-A71, enterovirus A71 EV-D68, enterovirus D68 Genetic GI, gastrointestinal highlight hnRNP, heterogenous nuclear ribonucleoprotein host cell receptor host cells ICAM, intercellular adhesion molecule include Infection Injury Innate immunity iPS, induced pluripotent stem cell IRES, internal ribosome entry site IVIG, intravenous immunoglobulin MDA, melanoma differentiation–associated protein metabolism molecular molecular feature motor neuron NCS, nerve conduction study pathogen Pathogenesis pathogenic receptor Research respiratory virus responsible RIG, retinoic acid–inducible gene severe respiratory illness similarity strain therapeutic approaches TLR, Toll-like receptor Toxicity Viral RNA virulence virus replication widespread [DOI] 10.1016/j.jbc.2021.100317 PMC 바로가기 [Article Type] JBC Reviews