Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfectionSARS-COV-2- 특이 적 CD4 반응의 관계 COVID-19 중증도 및 HIV-1 및 결핵 공동 감염의 영향Clinical Trial Published on 2021-06-152022-08-13 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] AIDS/HIV Antigen attributes CD4 Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity decrease Disease progression disease severity expression flow cytometry Frequency function HIV-1 HLA-DR hospitalized COVID-19 patients humoral immune response humoral immune responses immune responses implication involved knowledge magnitude Mycobacterium tuberculosis Patient patients phenotype proliferation reduced relationship SARS Coronavirus SARS-CoV-2 severe disease skewed Support T cell T cell depletion T cell response T cells the SARS-CoV-2 Tuberculosis [DOI] 10.1172/JCI149125 PMC 바로가기 [Article Type] Clinical Trial
First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19첫 번째 접종 mRNA 백신 접종은 COVID-19에서 회복된 피험자에서 SARS-CoV-2에 대한 면역학적 기억을 재활성화하기에 충분합니다.Article Published on 2021-06-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 진단, [키워드] Adaptive immune response Adaptive immunity B cell responses BNT162b2 mRNA cellular Clinical practice Cohort contrary COVID-19 COVID-19 vaccination COVID-19 vaccine determine ENhance evaluated humoral immune response IgA IgG IgM immune response Immunity immunoglobulins Immunological memory immunology individual individuals injection mandatory mRNA vaccination neutralizing antibodies titer performed question required SARS-CoV-2 SARS-COV-2 infection second dose serological subject subjects T cells tested vaccination vaccine dose vaccine injection [DOI] 10.1172/JCI149150 PMC 바로가기 [Article Type] Article
Landscape of epitopes targeted by T cells in 852 individuals recovered from COVID-19: Meta-analysis, immunoprevalence, and web platformCOVID-19에서 회복된 852명의 T 세포가 표적으로 하는 에피토프의 풍경: 메타 분석, 면역 유병률 및 웹 플랫폼Meta-Analysis Published on 2021-06-152022-09-11 Journal: Cell Reports Medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis CD4 CD8 Cohort cohorts complement convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines diagnostic diagnostics epitope Epitopes fraction help identify Immunity immunodominant immunodominant epitopes immunological Immunological studies immunoprevalent epitopes individual individuals information landscape majority Meta-analysis platform population coverage recorded SARS-CoV-2 severe acute respiratory syndrome Coronavirus T cell T cell epitope T cell epitopes T cell response T cell responses T cells tested Vaccine variants variants of concern web-based platform [DOI] 10.1016/j.xcrm.2021.100312 PMC 바로가기 [Article Type] Meta-Analysis
Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective studySARS-COV-2 감염을 앓고있는 무증상, 경미하고 중요한 증상 환자의 바이러스 부하, 림프구 서브 세트 및 사이토 카인 : 후 향적 연구Comparative Study Published on 2021-06-122022-09-01 Journal: Virology Journal [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age ANOVA Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic patient asymptomatic patients attack B cell B cells biological microscope Cell Chi-square Concentration coronavirus coronavirus disease coronavirus disease-2019 correlated COVID-19 Critical Critical case cytokine Cytokines diabetes Diabetes Mellitus disease enrolled Fisher Fisher's exact test flow cytometer Flow cytometric analysis group hospital Hospitalization IFN-α IFN-γ IL-10 IL-2 IL-5 IL-6 IL-8 IL10 IL2 IL4 IL5 IL6 IL8 infected individuals interleukin laboratory characteristics lymphocyte Lymphocyte subset Lymphocytes lymphopenia marker Microscope Mild Mild symptom mild symptoms NK cell NK cells No statistical differences occurred Patient patients patients with COVID-19 Plasma cytokine Pneumonia positively correlated respiratory Respiratory system Result Retrospective study RT-PCR SARS-CoV-2 SARS-COV-2 infection SCS severe acute respiratory syndrome Coronavirus severity of COVID-19 significant difference source of infection sputum statistical difference statistical differences subject subset symptomatic patient Symptomatic patients T cells T lymphocytes throat-swab TNF-α underlying disease underlying diseases variance Viral Viral load viral loads was used with COVID-19 [DOI] 10.1186/s12985-021-01597-x PMC 바로가기 [Article Type] Comparative Study
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset초기 T 세포 및 결합 항체 반응은 COVID-19 RNA 백신 효능 발병과 관련이 있습니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses Analysis binding binding antibodies binding antibody BNT162b2 BNT162b2 vaccine clinical trials Cohort Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research demonstrated detectable doses Efficacy element first dose glass healthcare worker hour immune responses Immunity Neutralizing Neutralizing activity Neutralizing antibodies Pfizer/BioNTech Phase III clinical trials primary endpoint receiving respiratory response responses RNA RNA vaccine RNA vaccines SARS-CoV-2 Severe acute respiratory syndrome single dose Support T cell T cells the vaccine undetectable vaccination Vaccine vaccine efficacy virus was performed with COVID-19 [DOI] 10.1016/j.medj.2021.04.003 PMC 바로가기 [Article Type] Article
Alterations in T and B cell function persist in convalescent COVID-19 patients회복 중인 COVID-19 환자에서 T 및 B 세포 기능의 변화가 지속됨Clinical and Translational Report Published on 2021-06-112022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단, [키워드] Abstract Activation acute COVID-19 Affect alteration B cell B cell subset B cells breathlessness caused CD8 change changes in Characteristics Clinical outcome clinical outcomes conducted Context contribute convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus disease COVID-19 COVID-19 patient cytokine defined disease Effect elevated Evidence examined fatigue finding Frequency functional funding Giving groups Health hospital discharge Hospitalization hospitalized COVID-19 patient identify IL-10 IL-17 IL-6 immune response Infection Long COVID longer-term immunity Lung disease Lung pathology lymphocyte Medicine Novel coronavirus outcome pandemic parameter Patient persistence phenotype Phenotypes phenotypic Population pro-inflammatory receptor restored skewed subgroup subgroups subsequent Symptom Symptoms T cell T cells Trust viral infection Wellcome Trust with COVID-19 [DOI] 10.1016/j.medj.2021.03.013 PMC 바로가기 [Article Type] Clinical and Translational Report
Interleukin-35 Suppresses Interleukin-9-Secreting CD4 + T Cell Activity in Patients With Hepatitis B-Related Hepatocellular CarcinomaOriginal Research Published on 2021-06-102023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus Hepatocellular carcinoma Interleukin-35 interleukin-9 T cells [DOI] 10.3389/fimmu.2021.645835 PMC 바로가기 [Article Type] Original Research
Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection지속적인 SARS-CoV-2 감염이 있는 COVID-19 환자의 임상 및 분자 특성Article Published on 2021-06-092022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Antimicrobial responses CD14 Cell Characteristics chemokines clinical correlation COVID-19 patient COVID-19 patients cytokine Cytokines described expression Genes healthy donor healthy donors immune characteristics Immune suppression Immunosuppression independent Infection interleukin LDs less lymphotoxin molecular molecular feature monocyte Monocytes natural killer Necrosis NK cell Pathways Patient patients patients with COVID-19 persistence persistent infection reduced Regulatory T cell regulatory T cells ribosomal protein RNA sequencing SARS-COV-2 infection short duration Single-cell RNA sequencing Systems analysis T cells TNF Tumor tumor necrosis tumor necrosis factor viral infection viral shedding [DOI] 10.1038/s41467-021-23621-y PMC 바로가기 [Article Type] Article
Diagnostic performance of four SARS-CoV-2 antibody assays in patients with COVID-19 or with bacterial and non-SARS-CoV-2 viral respiratory infectionsCOVID-19 환자 또는 박테리아 및 비 SARS-CoV-2 바이러스 호흡기 감염 환자에서 4가지 SARS-CoV-2 항체 분석의 진단 성능Comparative Study Published on 2021-06-092022-09-10 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody assays Bacterial bacterial and viral infections Bacterial infection Bacterial infections bacterial respiratory infections benefit Cell Chlamydia Control coronavirus COVID-19 COVID-19 patients cross-reactivity disease ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological studies Epidemiological study Euroimmun Evidence evidence of expressing false-positive result fatal disease highest IgA IgG Interpretation Legionella pneumophila Mycoplasma pneumoniae Patient patients with COVID-19 pneumoniae positive respiratory Respiratory disease respiratory infections SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 spike protein sensitivity sera serological evidence Specificities specificity Spike protein supplementary material T cells the SARS-CoV-2 vaccine response vaccine responses Viral viral infection viral infections viral respiratory viral respiratory infection Vircell vulnerable patients [DOI] 10.1007/s10096-021-04285-4 PMC 바로가기 [Article Type] Comparative Study