Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosisReview Published on 2020-08-012022-10-04 Journal: Seminars in Immunology [Category] 비임상, [키워드] Adaptive immunity adolescents and adult approach BCG candidate CD4+ CD8+ clinical evaluation correlates of protection diagnostics disease drug regimens effective Efficacy effort End endpoints Epidemic Factors high risk identify immune response immune responses include Infection Infectious disease Innate immunity Innate training Mycobacterium tuberculosis Next generation vaccine novel pathogen Population positive Protective protective immune response Protein Research revaccination stimulated Strategy sustained T cells Th1/Th17 Transmission Trial trials Tuberculosis Tuberculosis (TB) Vaccine vaccine candidate Vaccine development Vaccine(s) World Health Organization [DOI] 10.1016/j.smim.2020.101431 PMC 바로가기 [Article Type] Review
Transforming vaccine development백신 개발 혁신Review Published on 2020-08-012022-08-31 Journal: Seminars in Immunology [Category] MERS, 신약개발, [키워드] adjuvants clinical trials COVID-19 develop flexible Human Human genetics machine machine learning Platform technologies pressure Real world evidence Regulatory Regulatory convergence required SmaRT Smart clinical trials System Systems biology timeline Transforming unique urgency Vaccine Vaccine development Vaccine discovery Vaccines Vaccines safety. [DOI] 10.1016/j.smim.2020.101413 PMC 바로가기 [Article Type] Review
Implications of SARS-CoV-2 genetic diversity and mutations on pathogenicity of the COVID-19 and biomedical interventionsReview article Published on 2020-08-012022-10-05 Journal: Journal of Taibah University Medical Sciences [Category] 변종, [키워드] “COVID-19 Affect analysed Antiviral antivirals approach article caused Chemotherapy claimed Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical eligible European Evolution Factor filtered FIVE genetic diversity health emergency implication Intervention investigated Measures medical subject heading molecular mutant Mutation non-structural protein objective pathogenicity RdRP Result RNA-dependent RNA polymerase S protein SARS-CoV-2 serodiagnosis serodiagnostic Surveillance the S protein Transmission Treatment USA vaccination Vaccine development Vaccines virulence [DOI] 10.1016/j.jtumed.2020.06.005 [Article Type] Review article
Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primatesArticle Published on 2020-07-312022-10-29 Journal: Vaccine [Category] COVID-19, [키워드] antibody production Antibody titer CHO cell confirmed case COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 vaccine death evidenced examined expressing fusion protein global pandemic immunized immunogenic induce Infection injection live SARS-CoV-2 Live virus mice MOST Neutralizing activity neutralizing response Protein Pseudovirus neutralization assay recombinant responsible SARS-CoV-2 SARS-CoV-2 spike Spike protein STABLE Strong vaccination Vaccine Vaccine development virus virus neutralizing titer [DOI] 10.1016/j.vaccine.2020.06.066 PMC 바로가기 [Article Type] Article
Using COVID ‐19 as a teaching tool in a time of remote learning: A workflow for bioinformatic approaches to identifying candidates for therapeutic and vaccine development원격 학습 시대의 교육 도구로 COVID-19 사용: 치료제 및 백신 개발 후보를 식별하기 위한 생물정보학적 접근을 위한 워크플로Covid‐19 Published on 2020-07-292022-09-10 Journal: Biochemistry and Molecular Biology Education [Category] SARS, 치료제, [키워드] active learning approach approaches bioinformatics candidate cause cellular biology Computational biology COVID COVID‐19 creating Critical critical thinking develop Distance learning eliminating example flexible Genomics immunology information inquiry‐based teaching integration of research into undergraduate teaching involved knowledge Laboratory life microbes mind Molecular biology pandemic Research target therapeutic utility Vaccine Vaccine development Viral Virology virus [DOI] 10.1002/bmb.21413 PMC 바로가기 [Article Type] Covid‐19
Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccinesResearch Article Published on 2020-07-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] amplification analysed Analysis Antigen biological processe can be used change characterized condition coronavirus COVID-19 drug target effective effort globe host cell host response inactivated include infection kinetics information mass spectrometry modulated new virus overcome pandemic platform Prevent produced proteome proteomics resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell shotgun Spread Tandem mass spectrometry Vaccine Vaccine development viral amplification viral particle Viral particles viral protein detection virus [DOI] 10.1080/22221751.2020.1791737 PMC 바로가기 [Article Type] Research Article
Immunogenic SARS-CoV-2 Epitopes: In Silico Study Towards Better Understanding of COVID-19 Disease—Paving the Way for Vaccine DevelopmentArticle Published on 2020-07-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate amino acids analyses Antigen presentation Better binding caused COVID-19 COVID-19 outbreak COVID-19 patient deaths develop development effective elicit epitope Epitopes Factor FIVE help histocompatibility complex HLA homology modeling immune defense immune responses immunoinformatics in silico in silico analysis in vitro Infection MHC MHC class I epitopes MHC molecules molecular molecular dynamics simulations nine novel coronavirus SARS-CoV-2 novel coronaviruses outbreak outcome SARS-CoV SARS-CoV virus SARS-CoV-2 SARS-CoV-2 epitope sequence sequence similarity Spread structural biology T cell response T-cell triggering understanding Vaccine Vaccine development viral peptides virus [DOI] 10.3390/vaccines8030408 PMC 바로가기 [Article Type] Article
COVID-19: Mechanisms of Vaccination and ImmunityReview Published on 2020-07-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate Clinical management COVID-19 Critical Effects high affinity immune responses Immunity immunization induce Infection nucleic acid tests Prevent PROTECT Safe SARS-CoV-2 serology Trial vaccination Vaccination strategies Vaccine development vaccine platform Vaccines virus virus-neutralizing antibody [DOI] 10.3390/vaccines8030404 PMC 바로가기 [Article Type] Review
Expedited COVID-19 vaccine trials: a rat-race with challenges and ethical issuesPerspectives Published on 2020-07-222022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] candidate vaccine clinical trial COVID-19 COVID-19 vaccine COVID-19 virus drugs Ethics global effort management media molecular target MONITOR pandemic platform Research resource risk the vaccine timelines Trial Vaccine Vaccine development Volunteer [DOI] 10.11604/pamj.2020.36.206.23977 PMC 바로가기 [Article Type] Perspectives
The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization StrategiesImmunology Published on 2020-07-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accelerated acute respiratory syndrome addition animal models Candidates caused conditions coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop Diseases effective example First wave group Herd herd immunity human clinical trial human clinical trials immune response Immunity immunodeficiency immunopathology individual induction Influenza virus Intervention Long mass immunization measure Middle East morbidity and mortality Prophylactic reducing road SARS-CoV SARS-CoV-2 Spread Strategy technology vaccination Vaccine vaccine candidate Vaccine development weakened immune system [DOI] 10.3389/fimmu.2020.01817 PMC 바로가기 [Article Type] Immunology