Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 20192019년 코로나바이러스 질병 치료에서 Xuebijing 주사의 메커니즘 탐구에 대한 중국 전통 의학 네트워크 약리학 연구Article Published on 2020-12-012022-08-31 Journal: Chinese journal of natural medicines [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 Affect Analysis angiotensin Angiotensin-converting enzyme Anti-inflammatory Antiviral apigenin Chinese community-acquired pneumonia components Compound coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape database docked drug enrichment analysis Gene ontology help IL6 immune response indicated ingredient injection KEGG Kyoto Luteolin MAPK1 mechanism molecular docking multiple pathway multiple pathways network network pharmacology Ontology other compound other compounds overlapping Pathway enrichment analysis Perspective Pneumonia potential mechanism PPI network predict Proteins provided quercetin rutin S protein SALVIANOLIC ACID screened Sepsis Spike protein target target gene Target genes targets TCM TNF Traditional Chinese medicine treat Treatment with COVID-19 Xuebijing injection. [DOI] 10.1016/S1875-5364(20)60038-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predispositionSARS-CoV-2-특이 T 세포 반응 및 COVID-19 환자 소인과의 상관관계Clinical Trial Published on 2020-12-012022-08-31 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상, 치료법, [키워드] Active disease acute physiology and chronic health evaluation II acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed Antigen caused CD4+ CD4+ T cells cells cellular immunity cellular response Cellular responses Comorbidity comparable coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 defined died diminished disease elevated Ex vivo exhibited expression Factor Frequency global pandemic Health helper cell impairment individual intensive care magnitude membrane membrane protein Mild Mild disease moderate mounted nucleocapsid Patient patient age patients PD-1 predisposition proliferation Protein Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe infection Spike protein Spike proteins T cell T cell response T cell responses T cells T helper cell target Viral with COVID-19 [DOI] 10.1172/JCI140965 PMC 바로가기 [Article Type] Clinical Trial
Protein-Driven Mechanism of Multiorgan Damage in COVID-19Research article Published on 2020-12-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] activate biological networks candidate Combination COVID-19 damage damaged drug drug-drug interaction ellagic acid Endocrine Exosomes expressed Extracellular extracellular vesicle Extracellular vesicles eyes identify Lungs mathematical mechanism Multiorgan Multiorgan damage Musculoskeletal neurologic organ Perturbation predict Protein protein-protein interaction Proteins SARS-CoV-2 SARS-CoV-2 proteins severe COVID-19 patients Subdiffusion the lungs a treat [DOI] 10.1016/j.medidd.2020.100069 [Article Type] Research article
Interferon‐stimulated gene products as regulators of central carbon metabolismViewpoint Published on 2020-12-012022-10-31 Journal: The Febs Journal [Category] Coronavirus, MERS, SARS, [키워드] activate analyses Antigen antiviral immune response antiviral response biochemical carbon metabolism cellular COVID‐19 eicosanoid enzyme Evidence expression GAPDH gene product help immune response immunometabolism individual inhibit inhibiting innate immune response innate immune system interfere ISG ISGs mechanism metabolic product metabolite modulate modulating NFAT nitric oxide NOS Pathways performed Protein Proteins reaction regulate RSAD2 SAM stimulate Support viperin viral disease viral infections viral life cycle Viral proteins viral replication viruses [DOI] 10.1111/febs.15625 PMC 바로가기 [Article Type] Viewpoint
The Latest Achievements in the Construction of Influenza Virus Detection AptasensorsReview Published on 2020-11-302022-10-28 Journal: Viruses [Category] Coronavirus, SARS, [키워드] achievement addition aptamer Aptamers aptasensors cause changes in construction contribute death detection diagnostic disease DNA element example flu Infection Influenza Influenza virus initial nucleic acids pandemic Pathogens Protein Proteins Quantitative RNA selected sensitivity specificity Symptoms virus [DOI] 10.3390/v12121365 PMC 바로가기 [Article Type] Review
Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019Article Published on 2020-11-282022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] acute COVID-19 albumin association BMI body mass index C reactive protein coronavirus disease correlation COVID-19 COVID-19 prognosis defined determine diagnosed enrolled index Inflammation International Malnutrition men moderate nasal oxygen nutritional risk Patient patients percentage plasma presenting previous study Prognosis Proteins respiratory infections Retrospective study risk severe COVID-19 severity Support weight loss with COVID-19 [DOI] 10.3390/nu12123679 PMC 바로가기 [Article Type] Article
Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and VaccinesReview Published on 2020-11-282022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition Affect anticancer approach Cancer cancer treatment candidate CD8 Cell cell type cells co-stimulatory molecule complexes cytosolic DCs dendritic cell dendritic cell (DC) EVs Express extracellular vesicle extracellular vesicles (EVs) highlight histocompatibility complex Immune cell immune function immune response immune responses immune-suppressive tumor microenvironment Immunotherapy impair Interaction Intercellular communication Ligand lipids malignant membrane myeloid cell natural killer nucleic acid offer oncogenic oncopathogens Pathogens Perspective platform promote Prophylactic Proteins raised regulate rejection responses resulting RNAs secreted secreting simple stimulate stimulatory subset T cells therapeutic therapeutic option translate Transport Tumor tumor cells tumor-derived EVs unique Vaccine Vaccines variety Vesicle [DOI] 10.3390/cancers12123558 PMC 바로가기 [Article Type] Review
Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and TestingResearch Published on 2020-11-252022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID-19, SARS, [키워드] A549 ACE2 African green monkey Analysis approach BRCA1 Breast cancer Caco-2 Calu-3 can be used cause cell line change changed Chlorocebus clinical proteomics Cohort COVID-19 COVID-19 pandemic COVID-19 research diagnostic diagnostics evaluate Evidence expression expression data facilitate Factor feasibility genomes globe Innate immunity involved kDa label-free quantification manuscript mass spectrometry monitoring parallel reaction monitoring peer-reviewed peptides positive profile protease inhibitors Protein protein expression Proteins proteome proteomic proteomics Region representing Research SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 research Spread SRP9 stable-isotope labeling supernatant synthetic synthetic peptide targeted mass spectrometry Testing TMPRSS2 transcriptional regulators Vero Cell Vero E6 Vero E6 cell viral entry viral infection virus widespread [DOI] 10.1074/mcp.RA120.002164 PMC 바로가기 [Article Type] Research
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infectionSARS-CoV-2 감염의 3가지 동물 모델에서 높은 예방 및 치료 효능을 가진 인간 항체의 신속한 식별530 Published on 2020-11-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Ab1 ACE2 ADCC ADCC activity Administered aggregate aggregation animal model animal models antibody antibody-dependent cellular cytotoxicity Antigen assays BALB/c mice binding Combination competition Complete Coronaviruses COVID-19 Culture dose effective Efficacy elicited exhibited expressing Fab glycoprotein hACE2 hamster hamsters human ACE2 human cell human cell membrane human monoclonal antibodies Human monoclonal antibody IgG1 in vitro inhibited lack lowest mAb mAbs mechanism microbes monoclonal neutralization neutralized pandemic Prophylactic prophylactically Prophylaxis Protein Proteins public health threat Rapid RBD Receptor binding domain replication-competent SARS-CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 replication SARS-CoV-2 spike scFv sequence Significance somatic mutations tested the SARS-CoV-2 therapeutic antibodies therapeutic efficacy therapy tissue tissue culture transgenic mice Vaccines virus virus infection was selected wild-type [DOI] 10.1073/pnas.2010197117 PMC 바로가기 [Article Type] 530
A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID‐19 and Other VirusesCOVID-19 및 기타 바이러스 검출을 위한 압전 및 자기 변형 바이오 센서 재료 검토Review Published on 2020-11-242022-09-01 Journal: Advanced Materials (Deerfield Beach, Fla.) [Category] B형 간염, Fulltext, 진단, 치료기술, [키워드] (coronavirus disease 2019 acute respiratory syndrome acute respiratory syndrome coronavirus addition artificial intelligence Bacterial biosensor biosensors changed classical coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 critique data analytics Dengue detection detection properties Detection sensitivity Early detection Ebola electromagneto‐mechanical design examined experimental work Fever Final future work hepatitis B immunodeficiency IMPROVE Influenza influenza A Internet of Things limitations machine learning material MONITOR Other papilloma piezoelectric/magnetostrictive materials Progress Proteins Research researcher respiratory review severe acute respiratory syndrome Coronavirus spores Spread Threats vaccinia virus virus detection viruses [DOI] 10.1002/adma.202005448 PMC 바로가기 [Article Type] Review