Colchicine’s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial Research Published on 2020-05-272022-10-05 Journal: International journal of obesity (2005) [Category] SARS, 바이오마커, [키워드] addition adjust affected age analyzed Atherosclerosis baseline benefit Benjamini–Hochberg procedure blood sample BMI C-reactive protein cardiometabolic changed circulating clinical trial Colchicine colchicine’ collected Concentration COVID-19 demonstrated double-blind Effect Effects eight endothelial function Factor false discovery rate FDR groups IL-6 IMPROVE Inflammatory innate immune system involved low-density mechanism metabolism multiple testing not different obesity objective outcome oxidized Placebo post-intervention Protein Randomized Randomized controlled trial recent receptor Research Result secreted serum sample significantly significantly increased syndrome was used [DOI] 10.1038/s41366-020-0598-3 [Article Type] Research
Cross-sectional prevalence study of MERS-CoV in local and imported dromedary camels in Saudi Arabia, 2016-2018Research Article Published on 2020-05-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Active surveillance African age collected concurrent detection rate Endemic Epidemiology female highlight Horn of Africa Jeddah Local male Measures MERS-CoV Middle East NAb nasal swab neutralizing antibody Older positive positively correlated Prevalence prevalence study reduced respiratory RNA Sample Saudi Arabia screened sera Seroprevalence significantly increased Vaccine development Viral RNA viral RNA load virus widespread [DOI] 10.1371/journal.pone.0232790 PMC 바로가기 [Article Type] Research Article
Intensive Care Risk Estimation in COVID-19 Pneumonia Based on Clinical and Imaging Parameters: Experiences from the Munich CohortArticle Published on 2020-05-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Accuracy affected C-reactive protein characteristic clinical Clinical parameters collected Computed tomography Confirmed COVID-19 infection coronavirus disease Course COVID-19 CRP diagnostic estimation evaluate evaluated experience Ground glass opacity high risk ICU ICU Patients ICU treatment identify IL-6 imaging Infection intensive care intensive care unit Laboratory leukocyte lung lung parenchyma lymphocyte counts machine multivariate Munich parameter Patient PCR polymerase chain quantified radiological Radiological parameters radiologist random risk sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe disease course severity significantly significantly increased specificity Standard deviation Treatment Volume was performed [DOI] 10.3390/jcm9051514 PMC 바로가기 [Article Type] Article
Government Intervention, Risk Perception, and the Adoption of Protective Action Recommendations: Evidence from the COVID-19 Prevention and Control Experience of ChinaArticle Published on 2020-05-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Action adoption adoption of PARs bootstrap census China conducted Control coronavirus disease COVID-19 COVID-19 pandemic Effect effective experience form Gender Government government intervention Intervention likelihood mechanism Multiple regression Perception prevention proportion Protective recommendation Risk perception Sample size seeking significantly significantly increased [DOI] 10.3390/ijerph17103387 PMC 바로가기 [Article Type] Article
Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in ChildrenPediatrics Published on 2020-05-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abnormal coagulation Adenovirus age Appendicitis case sery CD16 CD3+ CD4+ CD56 CD8+ T lymphocytes Characteristics children Chlamydia clinical Clinical characteristics clinical feature consolidations cough Course COVID-19 CRP disease female Fever first manifestation FIVE gastroenteritis ground-glass opacity had no hemorrhage Hospitalized hydronephrosis hyponatremia IL-10 IL-6 Infection Influenza virus information kidney Legionella leukopenia liver Local lung lymphopenia male manifestation Myocardial natural killer cell non-respiratory symptoms novel coronavirus disease Novel coronavirus disease 2019 occurred one patient outbreak parainfluenza virus Pathogens Patient patients PCT pediatrics pleura positive ranged required respiratory syncytial virus SARS-CoV-2 SARS-CoV-2 nucleic acid Serum ferritin severe COVID-19 significantly increased spread to suppurative Symptom tested the disease the patient Treatment Two patient Wuhan Wuhan, China [DOI] 10.3389/fped.2020.00258 PMC 바로가기 [Article Type] Pediatrics
Immune responses to porcine epidemic diarrhea virus (PEDV) in swine and protection against subsequent infectionResearch Article Published on 2020-04-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] B cell Blood CD4/CD8 Cell cytometry analysis disease epidemic diarrhea evaluated fecal Flow Frequency humoral IgA IgG antibody immune response increase in Infection intestine Lymph node memory T cell MLN mucosal immune PEDV persist positive Prevent PROTECT Re-infection response RNA serum significantly higher significantly increased subsequent T cell understanding virus were infected [DOI] 10.1371/journal.pone.0231723 PMC 바로가기 [Article Type] Research Article
Prognostic value of NT-proBNP in patients with severe COVID-19중증 코로나19 환자에서 NT-proBNP의 예후 가치Research Published on 2020-04-152022-09-06 Journal: Respiratory Research [Category] Communicable Disease, COVID-19, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed best cardiac injury Case fatality rate caused China coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cut-off value defined enrolled Factors Fatality rate hospitalized patient hospitalized patients In-hospital death independent risk factor ineligible information Injury International medical records N Terminal NT-proBNP NT-proBNT outbreak outcome Patient peptide potential risk predicted Primary outcome public health emergency respiratory Result risk of death SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly increased specificity with COVID-19 [DOI] 10.1186/s12931-020-01352-w PMC 바로가기 [Article Type] Research
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysisArticle Published on 2020-04-102022-11-15 Journal: Clinical chemistry and laboratory medicine [Category] meta-analysis, SARS, 바이오마커, 변종, 비임상, 신약개발, 유전자 메커니즘, 임상, 치료기술, 치료법, 치료제, [키워드] 95% CI 95% confidence interval abnormality analyzed biochemical Biomarker China clinician CNKI Coagulation Cohort coronavirus disease COVID-19 Critical disease distress elevated evaluate fatal COVID-19 fatal disease form hematologic hospitalized patient identify IL-10 IL-6 immune Inflammation Infrastructure Injury interleukin Kidney function Laboratory laboratory abnormality Laboratory parameters liver lymphocyte Lymphocyte count marker mean difference measure Meta-analysis MONITOR Mortality non-survivor pandemic parameter Patient patients with COVID-19 Platelet predictor progression risk stratification Serum ferritin severe disease severity significantly significantly increased survivor Survivors the disease was performed WBC Web of Science while White blood cell [DOI] 10.1515/cclm-2020-0369
Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong KongOriginal Article Published on 2020-03-052022-10-30 Journal: Infection Control and Hospital Epidemiology [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus analyzed approach Appropriate Characteristics China Cluster Clusters collected confirmed case confirmed cases Contact tracing coronavirus disease COVID-19 diagnostic Epidemiology HCW HCWs healthcare worker Hong Kong hospital Infection infection control Isolation Laboratory measure molecular nasopharyngeal nosocomial Patient Pneumonia Prevent quarantine Saliva SARS-CoV-2 significantly increased surgical Surveillance the SARS-CoV-2 throat swabs transmission of SARS-CoV-2 Viral load was performed [DOI] 10.1017/ice.2020.58 PMC 바로가기 [Article Type] Original Article
Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis비알코올성 지방간염에서 미리오신의 치료 효과 및 자가포식 조절Research Published on 2019-10-212022-09-06 Journal: Lipids in Health and Disease [Category] B형 간염, Communicable Disease, [키워드] Acox-2 active CHB administration Adults alternate days analyzed animal model autophagy autophagy function autophagy marker autophagy markers ballooning blockade body weight ceramide ceramide signaling Ceramides change CHB chronic hepatitis Chronic Hepatitis B Control Cpt-1α de novo synthesis disease dyslipidemia elevated expression pattern Fabp1 fatty Fatty acid fatty acid metabolism Fatty liver fatty liver disease healthy hepatic autophagy function HepG2 cell HepG2 cells HFD-induced NASH High fat diet incubated Lipid accumulation liver Liver Biopsy liver biopsy-proven patient liver biopsy-proven patients Liver histology liver pathology lobular inflammation mechanisms metabolism myriocin NAFLD NASH NASH patient NASH patients Non-alcoholic fatty liver disease non-NASH patients nonalcoholic fatty liver Nonalcoholic Fatty Liver Disease oral administration Pathogenesis pathogenic Patient PPARα profiles qPCR qPCR analysis randomly divided RATs Registered Registration Regulation Regulatory restored Result reversed screened serum transaminase serum transaminases significantly significantly increased sphingolipid steatohepatitis steatosis subject three groups Treatment were measured [DOI] 10.1186/s12944-019-1118-0 PMC 바로가기 [Article Type] Research