Clinical characteristics, treatment, and prognosis of 74 2019 novel coronavirus disease patients in Hefei: A single-center retrospective study허페이의 2019년 신종 코로나바이러스 감염증 환자 74명의 임상적 특징, 치료 및 예후: 단일 센터 후향적 연구Comparative Study Published on 2021-05-282022-09-11 Journal: Medicine [Category] SARS, 치료제, [키워드] 2019 novel coronavirus Admission C-reactive protein C-reactive protein (CRP caused CD4/CD8 Characteristics China clinical Clinical characteristics Clinical data collected Computed tomography coronavirus disease cough COVID-19 COVID-19 patient COVID-19 patients Cytotoxic T cell Cytotoxic T cells disease epidemiological Epidemiology erythrocyte sedimentation erythrocyte sedimentation rate ESR expectoration fatigue followed by Hospitalization hospitalized patient ICU ICU patient ICU Patients Incubation period Inflammatory indicators intensive care intensive care unit Laboratory much higher non-ICU non-ICU patient non-ICU patients Novel coronavirus novel coronavirus disease nucleic acid Patient patients Pneumonia Prognosis proportion pulmonary computed tomography radiological Retrospective study SARS-CoV-2 sedimentation rate significantly higher single-center Spread Symptom symptom onset symptoms of infection T cells T helper cell T helper cells tested the median transmission of SARS-CoV-2 Treatment viral nucleic acid Wuhan [DOI] 10.1097/MD.0000000000025645 PMC 바로가기 [Article Type] Comparative Study
Deconvoluting the T Cell Response to SARS-CoV-2: Specificity Versus Chance and Cognate Cross-ReactivitySARS-CoV-2에 대한 T 세포 반응의 해체: 특이성 대 우연 및 동족 교차 반응성Immunology Published on 2021-05-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] Antibody Response Antigen antigens Biomarker chance characteristic clinically Cognate Cold common common cold common cold Coronaviruses coronavirus Course COVID-19 cross-reactive cross-reactivity ELISPOT exposure to False negative Human Immune monitoring immune protection Immunological memory ImmunoSpot individual individuals induce infected individual infected individuals infected with SARS-CoV-2 majority mega peptide pools Mild MOST negative control negative controls peptide peptide pool peptide pools provided respond response SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection serum antibodies serum antibody specific serum T cell T cell affinity T cell memory T cell response T cells Viral viral infections virus [DOI] 10.3389/fimmu.2021.635942 PMC 바로가기 [Article Type] Immunology
Regulatory KIR + RA + T cells accumulate with age and are highly activated during viral respiratory diseaseOriginal Paper Published on 2021-05-272022-10-28 Journal: Aging Cell [Category] COVID-19, MERS, SARS, [키워드] accumulate accumulated activated Activation addition Affect age aging Blood CD45RA CD8 CD8+ T cells characterized coronavirus COVID‐19 disease explain expresse expressed expression feature healthy individual identify Immune suppression immunological increase Infection Infectious disease Influenza influenza A Influenza virus killer‐cell immunoglobulin‐like receptors KIR marker Older older population phenotypical proliferation Regulation Regulatory regulatory T cells respiratory symptoms respiratory viral respiratory viral infection subset susceptibility T cell T cells T‐cell T‐cell response T‐cell responses T‐cell activation unique viral respiratory viral respiratory disease [DOI] 10.1111/acel.13372 PMC 바로가기 [Article Type] Original Paper
Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease SeverityICU에 입원한 COVID-19 환자의 PBMC에서 손상된 세포독성 반응: 질병 중증도를 예측하는 바이오마커Immunology Published on 2021-05-262022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Admission advance Algorithm analyzed association Biomarkers blood sample Blood samples cause CD4 CD8 lymphocytes + CD8+ T cell CD8+ T cells Cell cell population Cellular immune response center COVID-19 COVID-19 severity Critical cytotoxic cytotoxic cell cytotoxic response decrease develop effort elicit feature forest form hospitalized patients ICU IL-2 immune immune response immunological parameter Impaired infected cell infected cells Inflammatory response Invasive mechanical ventilation marker MHC class I MHC class I molecules NK and NKT cells NKT Novel coronavirus novel coronavirus SARS-CoV-2 pandemic parameter Patient PBMC plasma predict pseudotyped SARS-CoV-2 Random forest recruited reduce viral replication reduced response SARS-CoV-2 SARS-COV-2 infection Spain subpopulation susceptible T cell T cells target cell target cells Th1 the disease to define translated Tregs Viral viral replication [DOI] 10.3389/fimmu.2021.665329 PMC 바로가기 [Article Type] Immunology
Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?Review Published on 2021-05-262024-09-02 Journal: Cancers [Category] 대상포진, [키워드] Jak JAK inhibitor leukemia NK cells STAT T cells [DOI] 10.3390/cancers13112611 PMC 바로가기 [Article Type] Review
SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다Article Published on 2021-05-252022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술, [키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type [DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article
Immunosuppression as a Hallmark of Critical COVID-19: Prospective StudyArticle Published on 2021-05-232022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] adaptive Admission analyzed B cells Cell cells Clinical deterioration Clinical outcome comprehensive analysis Course COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill Cytokines dysregulation hospital Hospitalization ICU IL-2 IL-2/INFγ ratio Immunosuppression immunosuppressive impaired function INFγ Infection leukocyte lymphocyte subpopulation Lymphocyte subsets naïve NK cell NK cells non-ICU outcome outcomes Patient patients with COVID-19 performed Peripheral blood predict Prospective reductions in regulatory T cells required response SARS-CoV-2 SARS-COV-2 infection secreted subpopulations subsequent T cell T cells TCR γ/δ cells TCRα/β the disease the SARS-CoV-2 TNFα Treg cell Treg cells [DOI] 10.3390/cells10061293 PMC 바로가기 [Article Type] Article
Repeated Exposure to Subinfectious Doses of SARS-CoV-2 May Promote T Cell Immunity and Protection against Severe COVID-19SARS-CoV-2의 하위 감염 용량에 대한 반복적인 노출은 T 세포 면역 및 심각한 COVID-19에 대한 보호를 촉진할 수 있습니다Opinion Published on 2021-05-222022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] absence COVID-19 COVID-19 infection COVID-19 infections detrimental disease severity dose environmental exposure Europe European country exposure to facial masking Factor Factors fomites heterogeneous Hospitalization immune immune protection immunization increasingly induce Inflammation Intervention intestinal tract long term low-dose memory T cells Mortality observation pandemic positive protection protective immunity provided reducing respiratory resulting SARS-CoV-2 SARS-CoV-2 dynamics SARS-CoV-2 particles SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells severe COVID-19 short term Spread starting suggested T cell T cell memory T cell responses T cells transmissible variant vaccination Vaccinations Viral viral particle virus widespread [DOI] 10.3390/v13060961 PMC 바로가기 [Article Type] Opinion
Peripheral and lung resident memory T cell responses against SARS-CoV-2SARS-CoV-2에 대한 말초 및 폐 상주 기억 T 세포 반응Article Published on 2021-05-212022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute infection Anti-inflammatory Antiviral antiviral response Apoptosis apoptotic Biopsy material Blood CCR7 Cell cellular immunity circulating Clinical outcome Convalescent patients COVID-19 Cytokines degranulation disease severity functional highlight identify IFNγ IL-10 IL-12p70 IL-4 IL-4 responses Infection Infectious diseases initial limit lung lung biopsy lung parenchyma Lungs memory T memory T cell memory T cells modulated Mucosal immunology outcome Patient patients with COVID-19 peptide peptides peripheral persistence positioned profiles reduce Reinfection required resident respiratory respiratory tract response responses against SARS-CoV-2 SARS-COV-2 infection secreting severity Spread T cell T cell response T cell responses T cells these cell These cells Viral viral infection Viral protein Viral proteins virus-specific T cell window [DOI] 10.1038/s41467-021-23333-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19Review Published on 2021-05-212023-06-18 Journal: Cell Host & Microbe [Category] Fulltext, SARS, [키워드] CD4 CD8 Epitopes SARS-CoV-2 T cells [DOI] 10.1016/j.chom.2021.05.010 PMC 바로가기 [Article Type] Review