Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release AssaySARS-CoV-2 감염 후 구조 단백질의 광범위한 T 세포 표적화: 자동화된 인터페론 감마 방출 분석을 사용한 T 세포 반응성의 높은 처리량 평가Immunology Published on 2021-05-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] Antibody titer Antigen antigens approach assessment automated body mass body mass index breadth C-terminus characteristic comparable confirmed case confirmed cases Control control subjects convalescent coronavirus disease Coronavirus disease 2019 correlated COVID-19 days post infection Elecsy Elecsys facilitate followed by fresh whole blood Gamma groups high accuracy high through put IgG immune response immune responses Infection interferon gamma interferon gamma release assay (IGRA) large cohort less magnitude membrane nucleocapsid PCR positive Protein reactivity Release Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SCT seropositive seropositive individual Seropositivity Sex significantly specific antibodies structural protein structural proteins subject T cell T cell response T cell responses T cells targeting targets tested throughput virion virus was performed were assessed Whole blood [DOI] 10.3389/fimmu.2021.688436 PMC 바로가기 [Article Type] Immunology
Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age풍토성 코로나바이러스에 의해 유도된 순환하는 CD4 T 세포는 항원 특이성 및 연령과 관련된 풍부함 및 기능적 잠재력에 있어 큰 격차를 나타냅니다.Article Published on 2021-05-202022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age CD4 CD4 T cell CD4 T cells Cell Cell-mediated immunity circulating collected comparable coronavirus cross-reactive disparity display endemic human coronavirus endemic human coronaviruses epitope Epitopes evaluated examined functional granzyme granzyme B HCoV Infection Influenza interferon interferon-γ interleukin interleukin-2 lack long-lasting memory cell Memory cells nucleocapsid Potential protective immunity reactivity recruited recruitment response robust SARS-CoV infection SARS-CoV infections SARS-CoV-2 SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus specificity Spike proteins Stimulation subject subjects T cells thought Vaccinations Viral antigen [DOI] 10.1093/infdis/jiab076 PMC 바로가기 [Article Type] Article
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석Report Published on 2021-05-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법, [키워드] CD4 Clonal analysis clone clones conserved Coronaviruses cross-reactive cross-reactivity effector Endemic epitope Epitopes helper HLA-DP HLA-DR identify immunodominance immunodominant individual individuals memory T cells nucleoprotein processed robust S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants Subunit vaccine subunit vaccines T cell T cell epitope T cell epitopes T cell response T cells the RBD Vaccination strategies Vaccination strategy [DOI] 10.1126/science.abg8985 PMC 바로가기 [Article Type] Report
HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children어린이의 다기관 염증 증후군에서 TRBV11-2 T 세포의 HLA 클래스 I 관련 확장Article Published on 2021-05-172022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, [키워드] Activation allele Antigen Bacterial CDR3 characterized children clinical feature Clinical features clone complementarity-determining region correlated COVID-19 distribution HLA HLA class I HLA class I alleles Hyperinflammatory syndrome immunology indicated Inflammatory Interaction mechanism MIS-C motif Patient residue SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum cytokine levels severity Shock specificity spike glycoprotein superantigen syndrome T cell T cell receptor T cells TCR Toxic shock Toxic shock syndrome TRBV11-2 triggered [DOI] 10.1172/JCI146614 PMC 바로가기 [Article Type] Article
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice자가 증폭 RNA 및 아데노바이러스 COVID 백신을 사용한 이종 백신 요법은 생쥐에서 강력한 면역 반응을 유도합니다Article Published on 2021-05-172022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Adaptive immunity Antibody Response Antibody responses boost CD4 T cells Cellular immune response ChAdOx1 clinical trial clinical trials comparable COVID COVID-19 Cytotoxic T cell Cytotoxic T cells demonstrated disease Efficacy example Heterologous heterologous prime-boost heterologous vaccination regimen heterologous vaccination regimens homologous immune response immunogenicity induce Infectious diseases mice Neutralising titre regimen regimens RNA RNA vaccine robust SARS-CoV-2 Single-dose T cells Th1 titre titres vaccination Vaccine Vaccines vectored vaccine viral vectors [DOI] 10.1038/s41467-021-23173-1 PMC 바로가기 [Article Type] Article
Functional characterization of CD4 + T cell receptors crossreactive for SARS-CoV-2 and endemic coronavirusesArticle Published on 2021-05-172023-07-01 Journal: The Journal of Clinical Investigation [Category] SARS, [키워드] COVID-19 immunology Imprinting MHC class 2 T cells [DOI] 10.1172/JCI146922 PMC 바로가기
Immunological Aspects of SARS-CoV-2 Infection and the Putative Beneficial Role of Vitamin-DReview Published on 2021-05-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression activating Activation acute respiratory syndrome adaptive Adaptive immunity Alveolar Type II amplification angiotensin-converting enzyme 2 antibody Antigen antimicrobial peptide aspect attenuate autophagy B cells Bioavailability caused CD4 Cell cells circulating combating complex Concentration coronavirus Coronavirus disease 2019 Coronavirus-2 correlated COVID-19 criteria cytokine release Cytokine storm Cytokine storms defend Degradation determine dosage Effectiveness ENhance enzyme epithelial cell Evidence expression Future Health immune response Immunity incidence increase individuals with COVID-19 infect Inflammation inhibit inhibiting Innate immunity Interaction Local lysosomal macrophages mechanism meet Multiple nuclear observation Organ failure Particle Population pro-inflammatory cytokine progression promote RAS receptors renin–angiotensin–aldosterone system required responsible role SARS-CoV-2 SARS-CoV-2 viral particles secretion serum severe acute respiratory syndrome coronavirus 2 severity of COVID-19 shown Signaling Spike protein suppresse T cell T cells T helper tissue Toll-like receptor virus Vitamin D Vitamin D supplementation [DOI] 10.3390/ijms22105251 PMC 바로가기 [Article Type] Review
Old and new coronaviruses in the elderlyEditorial Published on 2021-05-152022-10-28 Journal: Aging (Albany NY) [Category] Coronavirus, SARS, [키워드] coronavirus COVID-19 cross-reactive memory HCoV immunosenescence SARS-CoV-2 T cells [DOI] 10.18632/aging.203065 PMC 바로가기 [Article Type] Editorial
Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity지속적인 COVID-19 증상은 SARS-CoV-2-특이적 T 세포 면역의 발달에 최소한의 영향을 미칩니다Article Published on 2021-05-152022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] 229E accompanied analyzed Cellular immune response cellular immunity complications convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 COVID-19 symptom COVID-19 symptoms development Diagnosis dysregulated dysregulation eight human coronaviruses human coronaviruses 229E Impact individual infected individuals Infection initial majority Mild-to-moderate N protein NL63 persistent persistent COVID-19 symptom Persistent COVID-19 symptoms public health reactivity regulate SARS-CoV-2 SARS-CoV-2-infected individual SARS-CoV-2-infected individuals Symptom symptom duration T cells the N protein Viral viral infection viral infections virus-specific cellular immunity while [DOI] 10.3390/v13050916 PMC 바로가기 [Article Type] Article
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface임신 중 산모 호흡기 SARS-CoV-2 감염은 산모-태아 경계면에서 강력한 염증 반응과 관련이 있습니다Article Published on 2021-05-142022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Cell cells center Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable early pregnancy exhibited full term Genes had no healthy histology Hofbauer cells immortalized cell line immortalized cell lines immune immune activation immune mechanism immune responses immunohistochemistry in vitro in vivo increased expression increased risk Infection Inflammatory response Local majority marker Maternal morbidity natural killer NIH outcome pathophysiology performed Placenta placental Placentas precursor precursors preeclampsia Pregnancy pregnancy complications pregnant women PROTECT respiratory robust SARS-CoV-2 SARS-COV-2 infection shielding single-cell stem cell stem cells Support T cells transcriptomics Viral viral infection viral invasion Viral RNA women [DOI] 10.1016/j.medj.2021.04.016 PMC 바로가기 [Article Type] Article