To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell AnalysisTo Ki 또는 Not to Ki: T 세포 분석을 위한 Ki-67의 사용 및 잠재력 재평가Immunology Published on 2021-04-092022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] analyses Analysis analyzed Antigen antigen-specific CD8 T cells approach Autoimmune disease Autoimmune diseases blood sample can be used Cancer immunotherapy Care CD8 T cell CD8 T cells Cell cell cycle cells clonal expansion COVID-19 demonstrated diabetes DNA dye dual effective example excluded experimental work flow cytometric flow cytometry Health Health care healthy donors human peripheral blood identify immune infections infectious mononucleosis Ki-67 lab lymphocyte Lymphocytes marker mice offer organ-specific Patient Peripheral blood phenotypic Potential proliferation provide provoke re-evaluation staining T cell T cell proliferation T cells tissues Type 1 diabetes window [DOI] 10.3389/fimmu.2021.653974 PMC 바로가기 [Article Type] Immunology
T cell reactivity to regulatory factor X4 in type 1 narcolepsyArticle Published on 2021-04-092023-06-08 Journal: Scientific Reports [Category] 신종인플루엔자, [키워드] Autoimmune diseases Autoimmunity Circadian rhythms and sleep Hypocretin immunology Neuroimmunology neuroscience Orexin Sleep T cells [DOI] 10.1038/s41598-021-87481-8 PMC 바로가기 [Article Type] Article
Persistent cellular immunity to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 지속적인 세포 면역Article Published on 2021-04-052022-09-10 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 바이오마커, [키워드] addition affected alteration average CD4 CD8 Cell cell division cellular immunity contribute elicit expression functional globe immune response individual individuals Infection memory memory T cells pandemic persistent reactive recall recovered responses responsible SARS-CoV-2 SARS-COV-2 infection T cell T cell memory T cell response T cell responses T cells [DOI] 10.1084/jem.20202515 PMC 바로가기 [Article Type] Article
Recent advances in non-specific immune memory against bovine tuberculosisReview article Published on 2021-04-012022-10-05 Journal: Comparative Immunology, Microbiology and Infectious Diseases [Category] 비임상, [키워드] Affect bovine Bovine tuberculosis diagnostic disease Gamma delta T cells hosts humans immune memory immune response immune response mechanism innate immune response Interaction knowledge mammals Mycobacterium bovis non-specific recent recent finding Support T cells trained immunity Tuberculosis Vaccine [DOI] 10.1016/j.cimid.2021.101615 [Article Type] Review article
Prognostic roles of KL-6 in disease severity and lung injury in COVID-19 patients: A longitudinal retrospective analysisCOVID-19 환자의 질병 중증도 및 폐 손상에서 KL-6의 예후 역할: 종단적 후향적 분석Article Published on 2021-04-012022-08-31 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] Biomarker change clinical information coagulation disorders Cohort collected Computed tomography Concentration conducted coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID-19 COVID-19 patient COVID-19 severity discharge discharged patients disease severity elevated follow-up period KL-6 Laboratory test Laboratory tests lung Lung injury lung lesion lung lesions median Mild mild COVID-19 patient mild patient mild patients noninvasive parameter Patient Pearson Pearson R Prognosis Prognostic value Retrospective analysis serum significantly significantly higher subset T cell T cells U/mL [DOI] 10.1002/jmv.26793 PMC 바로가기 [Article Type] Article
Convalescent plasma, cytomegalovirus infection, and persistent leukopenia in COVID-19 recovery phase: What is the link?코로나19 회복기 회복기 혈장, 거대세포바이러스 감염, 지속성 백혈구 감소증: 연관성은?Case Reports Published on 2021-04-012022-09-11 Journal: Journal of postgraduate medicine [Category] SARS, 치료제, [키워드] Co-infection complete recovery convalescent plasma Corticosteroid Corticosteroids Course COVID-19 COVID-19 infection cytomegalovirus cytomegalovirus infection decrease diagnosed discharge Dysphagia fluconazole Ganciclovir high risk hospital Immunity Immunosuppression Infection intravenous latent infection leukopenia leukopenia. male NK cell NK cells Oropharyngeal Patient persistent plasma Reactivation Secondary infection Severe COVID-19 Infection sick suffered supportive therapies suspicion synergistic T cell T cells thrush treated worsened [DOI] 10.4103/jpgm.JPGM_1168_20 PMC 바로가기 [Article Type] Case Reports
Pronounce expression of Tim-3 and CD39 but not PD1 defines CD8 T cells in critical Covid-19 patientsPD1이 아닌 Tim-3 및 CD39의 발현은 중요한 Covid-19 환자에서 CD8 T 세포를 정의합니다Article Published on 2021-04-012022-08-31 Journal: Microbial pathogenesis [Category] MERS, SARS, 바이오마커, 진단, [키워드] (PD-1) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD39 CD8 CD8 T cell CD8 T cells CD8 T-cell Cell cell counts cells combinations coronavirus coronavirus disease COVID-19 Critical dysregulated immune response Exhausted cell expressing expression Frequency group healthy control healthy controls Immunoglobulin individual inhibitory receptor Inhibitory Receptors Lymphocytes marker mononuclear cell mononuclear cells mucin New coronavirus no difference no significant differences Patient patients patients with COVID-19 PBMCs PD-1 PD1 Peripheral blood Peripheral blood mononuclear cells phenotype programmed cell death programmed cell death protein Pronounce Protein recruited Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant difference significant differences significantly lower subject T cells T lymphocyte T lymphocytes T-cell the healthy three group three groups TIM-3 Viral viral infection [DOI] 10.1016/j.micpath.2021.104779 PMC 바로가기 [Article Type] Article
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protectionSARS-CoV-2에 대한 인간 중화 항체는 최적의 치료 보호를 위해 온전한 Fc 효과기 기능을 필요로 합니다Article Published on 2021-04-012022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Administered antibody benefit caused CD8 CD8+ CD8+ T cells Cell clinical trials COVID-19 pandemic Depletion disease effector function function hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IMPROVE in vivo Infection Inflammation innate immune loss-of-function lung Lung disease Lung infection lung; mAb mAbs mechanism of action mice mitigate monocyte Monocytes mouse model Neutralizing Neutralizing antibodies neutralizing antibody Pathogenesis phenotype preserved Prophylaxis reduce required respiratory Respiratory mechanics RNA RNA sequencing SARS-CoV-2 Signaling T cell T cells therapeutic therapy tissue repair transcriptional variant Virological [DOI] 10.1016/j.cell.2021.02.026 PMC 바로가기 [Article Type] Article
Pre-existing T-cell immunity to SARS-CoV-2 in unexposed healthy controls in Ecuador, as detected with a COVID-19 Interferon-Gamma Release AssayArticle Published on 2021-04-012023-06-19 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, [키워드] COVID-19 ELISPOT Interferon-gamma (IFN-γ) release assay (IGRA) nucleocapsid protein pre-existing immunity SARS-CoV-2 Spike protein T cells [DOI] 10.1016/j.ijid.2021.02.034 PMC 바로가기
Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019말초 호중구 및 T-림프구 하위 집합을 모니터링하면 코로나바이러스 질병 2019의 중증도와 질병 진행을 구별하는 데 도움이 될 수 있습니다Research Paper Published on 2021-03-312022-09-10 Journal: Aging (Albany NY) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis analyzed Antiviral assist AUC baseline CD3+ CD3+CD4+ CD3+CD4+ T cells CD3+CD8+ CD4+ CD4+ T lymphocyte CD8+ T cells center characteristic clinical Clinical significance clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytotoxic T cell Cytotoxic T cells disease Disease progression evaluate expression help helper helper T cells lymphocyte Lymphocytes monitoring neutrophil neutrophil to CD4+ T lymphocyte ratio/N4R NK cell NK cells patients with COVID-19 peripheral lymphocyte Potential biomarker potential biomarkers progression Public receiver operating characteristic respiratory SARS-CoV-2 SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus severity subset T cell T cells T lymphocyte T-cell test negative therapy [DOI] 10.18632/aging.202701 PMC 바로가기 [Article Type] Research Paper