ACE2 protein – Page 7 – Communicable Diseases Research

SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19

안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향

Article

Published on 2021-04-252022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women
[DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

SARS-CoV-2에 대한 인간 ACE2 수용체 다형성 및 변경된 감수성

Article

Published on 2021-04-122022-09-10
Journal: Communications Biology [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 protein ACE2 receptor ACE2 variant ACE2 variants Affect affecting affinity Alter analyzed angiotensin assays binding biochemical caused CoV S-protein COVID-19 dataset E35K effective engage entry of SARS-CoV-2 genomic group higher affinity host cell host cells host susceptibility Human human Angiotensin-converting enzyme identify include Interaction modulate Molecular biology Novel coronavirus polymorphism population groups predicted Protective Protein Proteins Pseudotyped virus receptor reported representing respiratory Respiratory illness S-protein SARS-CoV SARS-CoV-2 soluble ACE2 susceptibility variant variants Viral viral spike virus–host interactions wild-type wildtype
[DOI] 10.1038/s42003-021-02030-3 PMC 바로가기 [Article Type] Article

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection

Research Article

Published on 2021-04-092022-10-27
Journal: BioMed Research International [Category]

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection

Research Article

Published on 2021-04-092022-10-27
Journal: BioMed Research International [Category] COVID-19, MERS, SARS,

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection

인간 ACE2 유전자의 고위험 미스센스 변이체 및 SARS-CoV-2 감염에 대한 감수성의 실리코 분석

Research Article

Published on 2021-04-092022-09-10
Journal: BioMed Research International [Category] 변종,

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

폐 상피 세포에서 E3 유비퀴틴 리가제 Skp2에 의한 SARS-CoV-2 수용체 ACE2의 분해

Article

Published on 2021-04-012022-09-12
Journal: Frontiers of medicine [Category] MERS, SARS, 진단,

Evidence for CAT gene being functionally involved in the susceptibility of COVID-19

CAT 유전자가 COVID-19의 감수성에 기능적으로 관련되어 있다는 증거

Review

Published on 2021-04-012022-09-11
Journal: FASEB journal : official publication of the Federa [Category] SARS, 변종,

[키워드] ACE2 ACE2 protein acting addition affecting Analysis binding bioinformatics Bioinformatics analysis candidate gene caused Cell cell membrane coronary pneumonia coronavirus COVID-19 disease distress DNA variants Effectiveness EHF eQTL Evidence expression Extracellular Genes Genetic Genetic variant genetic variants Genome-wide association study GWASs Interaction Intracellular Invasion involved Lungs molecular novel positive correlation potential risk Prognosis Protein Protein binding protein interaction regulate regulated reported respiratory distress Respiratory distress syndrome S protein starting susceptibility syndrome Treatment understanding variant
[DOI] 10.1096/fj.202100008 PMC 바로가기 [Article Type] Review

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.

Research Article

Published on 2021-03-242022-08-13
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein
[DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

423

Published on 2021-03-232022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, Fulltext, SARS, 조류인플루엔자,

[키워드] ACE2 ACE2 ortholog ACE2 protein analyses Analysis angiotensin-converting enzyme 2 bat caused characterized chose close contact coronavirus COVID-19 Cross-species transmission facilitate FIVE functional Genetic genetic analysis Health highlight Host host cell host range host receptor host tropism hosts hotspot Human infect Interaction intermediate host mammal mammalian MONITOR New World monkey ortholog outbreak Outbreaks pandemic of COVID-19 predicted Prevent receptor receptor ACE2 reservoir residue restrict reveal risk SARS-CoV-2 SARS-CoV-2 entry Significance Spike protein Support susceptible the SARS-CoV-2 Transmission viral entry zoonotic
[DOI] 10.1073/pnas.2025373118 PMC 바로가기 [Article Type] 423

Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 Research

SARS-CoV-2 연구에서 단백질 2차 구조 알고리즘의 적용

Review

Published on 2021-03-052022-09-11
Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors Algorithm Algorithms Amino acid amino acid sequence Analysis application binding affinity can be used can not compare protein Complete computational tool computational tools Contact Course COVID-19 evaluate example experiments explained faster Genome global effort help highlight homology information nucleotide pandemic Pandemics Protein protein similarity protein structure question reflected required Research SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure sequence sequence similarities similarity Spike protein Structure the binding affinity Vaccine design viruses while zoonotic origin zoonotic origins
[DOI] 10.1021/acs.jproteome.0c00734 PMC 바로가기 [Article Type] Review