COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective surveyArticle Published on 2021-06-022022-10-30 Journal: Leukemia [Category] COVID-19, MERS, SARS, [키워드] Admission Allogeneic Analysis autologous Cell cell transplantation COVID-19 COVID-19 patient Diagnosis disease European Factor group GVHD haematological diseases HCT hematopoietic high risk ICU immunodeficiency Immunosuppression increased mortality increased the risk Infectious diseases Lower respiratory tract Marrow median age median time Mortality multicenter Older age Other overall survival Patient patients performance status recipients reported risk significantly Society Spanish STEM survival transplantation [DOI] 10.1038/s41375-021-01302-5 PMC 바로가기 [Article Type] Article
Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 PatientsImmunology Published on 2021-06-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptive affected age Allogeneic alloHSCT immunology analyzed approach Cell co-morbidities collected data Comorbidities Course COVID-19 COVID-19 immunology COVID-19 patient COVID-19 patients cytokine cytokine overproduction cytokine production Cytokine release syndrome Cytopathic effect damaged DAMP Deleterious deteriorate disease event expression facilitated Factor Genes Genetic hallmark highlighting HLADR homeostasis Host immune system Immunity immunogenetic profiling Increases Inflammatory cytokines inflammatory process Interaction intracellular signaling Invasion laboratory data Malnutrition modify molecular monocyte monocytic-marrow derived suppressor cells over-production of cytokine overproduction pathogenicity pathway Patient patients pro-inflammatory cytokines receptors regimen released respond sequence severity Signal transduction similarity spreads stimulate System TCR beta repertoire tissue Transcription turn vicious cycle virus virus infection [DOI] 10.3389/fimmu.2021.658896 PMC 바로가기 [Article Type] Immunology
Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report중증 코로나19 환자의 온정 간엽줄기세포 치료: 증례보고Case Reports Published on 2021-06-012022-09-10 Journal: Croatian Medical Journal [Category] MERS, SARS, 신약개발, [키워드] 49 days acute respiratory distress acute respiratory distress syndrome addition affected Allogeneic Antiviral ARDS attending physicians Bacterial infection Case report Cell Clinical course cold-like symptom cold-like symptoms compassionate use COVID-19 discharged Exhaustion family general condition hospital immunosuppressive intensive care intensive care unit mechanically ventilated Mesenchymal stem cells MSC MSC therapy Patient physician rapid clinical deterioration respiratory distress severe COVID-19 severe symptom severe symptoms Side effect stem cell supportive therapy syndrome therapy Treatment Trial [DOI] 10.3325/cmj.2021.62.288 PMC 바로가기 [Article Type] Case Reports
Safety and immunogenicity of a first dose of SARS‐CoV‐2 mRNA vaccine in allogeneic hematopoietic stem‐cells recipientsShort Report Published on 2021-06-012022-10-31 Journal: Ejhaem [Category] COVID-19, [키워드] absence Allogeneic Chemotherapy Control control arm Efficacy and safety Elecsys Factor first dose healthy controls Immunosuppressive treatment injection lymphopenia Messenger RNA mRNA vaccine of BNT162b2 Patient patients Pfizer‐BioNTech Prospective Study provide rate of seroconversion receptor‐binding domain recipient Roche Safe Safety SARS‐CoV‐2 Spike protein vaccination Vaccine was tested [DOI] 10.1002/jha2.242 PMC 바로가기 [Article Type] Short Report
Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cellsMesenchymal Stem Cells Published on 2021-05-192022-10-28 Journal: Stem cells translational medicine [Category] Coronavirus, SARS, [키워드] addition advance Allogeneic Autoimmune diseases autologous Cell clinical trial clinical trials COVID‐19 demonstrated Efficacy Endpoint Evidence Exosome Exosomes Extracellular vesicles graft rejection Human human pluripotent stem cells immune Immune cell immunomodulatory property Increasing indication Inflammatory inflammatory disease inflammatory disorders liver Liver cirrhosis mesenchymal stem cell mesenchymal stem/stromal cell therapy MSC MSCs organ transplantation Osteoarthritis outcome prevalent pulmonary disease pulmonary inflammation rejection stem cell Stem cell therapy supported therapeutic therapeutic use therapy tissue Trial while [DOI] 10.1002/sctm.21-0021 PMC 바로가기 [Article Type] Mesenchymal Stem Cells
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment급성 호흡곤란 증후군에서 중간엽 줄기세포의 치료 기전은 Covid-19 치료의 가능성을 보여줍니다Review Published on 2021-05-102022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 비임상, [키워드] acute respiratory distress acute respiratory distress syndrome adipose Adipose tissue administration adverse effect adverse effects Allogeneic analyzed animal experiments ARDS attenuate Bone marrow breath cell infusion cells Clinical studies clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients cytokine Cytokines Effects Endoplasmic reticulum Evidence Exosome Exosomes experiment fibrosis highlight inflammatory cells inhibit mechanism mesenchymal stem cell Mesenchymal stem cells modulate mortality rate MSC MSC therapy MSCs paracrine patients with ARDS pulmonary fibrosis raising recent respiratory distress severe COVID-19 stem cell Stress syndrome therapeutic tissue Treatment umbilical Umbilical cord [DOI] 10.1186/s12967-021-02862-x PMC 바로가기 [Article Type] Review
Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapyCOVID-19 및 암 면역 요법에서 공유된 염증 경로 및 치료 전략Article Published on 2021-05-012022-09-12 Journal: Journal for immunotherapy of cancer [Category] SARS, 진단, [키워드] acute respiratory distress adverse event Allogeneic anti-inflammatory drug Anti-inflammatory therapy antibody Antigen approach ARDS benefit Cancer immunotherapy caused Cell cells characterized chimeric circulating cytokines clinical trial Complication coronavirus COVID-19 CRS cytokine disease drug drugs Effect elevated Endothelial dysfunction exaggerated immune response Graft-versus-host disease help Hospitalization immune system Immunotherapy infection with SARS-CoV-2 Inflammation Inflammation mediators Inflammatory inflammatory pathway inhibiting interleukin-6 interstitial involved mechanism monoclonal antibody Mortality pathogenesis of COVID-19 pathway performed preliminary evidence reducing reduction in SARS-COV-2 infection stimulate suppress syndrome systematic review systemic manifestation therapeutic strategy therapy toxicities Toxicity Treatment trials triggered viral infection [DOI] 10.1136/jitc-2021-002392 PMC 바로가기 [Article Type] Article
Allogeneic transplant procurement in the times of COVID-19: Quality report from the central European cryopreservation siteCOVID-19 시대의 동종 이식 조달: 중앙 유럽 냉동 보존 사이트의 품질 보고서Research Published on 2021-04-082022-09-10 Journal: Journal of Translational Medicine [Category] MERS, 바이오마커, 진단, [키워드] addition Administered Allogeneic analyzed apheresis CD34 CD34+ cell enumeration Cell Cell therapy Concentration correlation COVID-19 pandemic cryopreservation cryoprotectant DMSO Donor dose Engraftment Europe European Evidence evidence of examined feasible freezing Graft Graft quality Hematopoietic stem cell instances Laboratory leukocyte limitation neutrophil no evidence of Patient Platelet Post-thaw recovery product Quality Quality control Result Single Cell stem cell Stem cell dose Stem cell enumeration stem cells supplementary material therapy time lag Transplant Transplant logistics viability was selected while [DOI] 10.1186/s12967-021-02810-9 PMC 바로가기 [Article Type] Research
Case Report: Severe COVID-19 Pneumonia in a Patient With Relapsed/Refractory Hodgkin’s LymphomaOncology Published on 2021-03-182022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] acute respiratory distress adverse outcome Allogeneic allogeneic stem cell ARDS autologous brentuximab Cancer Chemotherapy China coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Donor donor lymphocyte infusion EBV Effect expected global pandemic graft-versus-host-disease GVHD haematological malignancy Hodgkin’s lymphoma Immunosuppression lymphocyte lymphoma lymphoproliferative disease multiorgan failure Patient reported risk Severe COVID-19 pneumonia Stem cell transplantation suffered syndrome therapy treated viral infection [DOI] 10.3389/fonc.2021.601709 PMC 바로가기 [Article Type] Oncology
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiencyX-연관 중증 복합 면역결핍증이 있는 유아의 간염과 관련된 SARS-CoV-2 감염Case Reports Published on 2021-03-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 치료기술, [키워드] adaptive Adaptive immunity Allogeneic Antigen B cells caused CD34 Cell clinically combined immunodeficiency Conditioning convalescent plasma COVID-19 deficiencies deficiency disorder Donor dysfunction Gene therapy Hepatitis IL-2 receptor Immunity immunodeficiency Inborn error inborn errors of immunity Infant infected with SARS-CoV-2 Mutation Nasopharyngeal swab nasopharyngeal swabs Natural killer cells NK cells opportunistic Infections Patient respiratory respiratory symptom respiratory symptoms resulting RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibodies SCID selected severe combined immunodeficiency specific antibodies stem cell Transplant transplantation treated X-linked [DOI] 10.1016/j.clim.2020.108662 PMC 바로가기 [Article Type] Case Reports