analogue – Page 7 – Communicable Diseases Research

Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2

Article

Published on 2021-02-252022-10-29
Journal: Microorganisms [Category] COVID-19,

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus

글루코실세라마이드 합성효소 억제제는 SARS-CoV-2 및 인플루엔자 바이러스의 복제를 방지합니다

Accelerated Communication

Published on 2021-02-252022-09-10
Journal: The Journal of Biological Chemistry [Category] 비임상, 신종인플루엔자,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analogue antiviral drugs Antiviral effect antiviral therapies breath caused CC50, cytotoxicity concentration 50% cell membranes Cerdelga clinical trials component coronavirus COVID-19 COVID-19 pandemic CPE, cytopathic effect creating cross DENV, dengue virus dependency disrupt DMSO, dimethyl sulfoxide DNJ, deoxynojirimycin drug Drug administration DsiRNA, Dicer-substrate siRNA examined food GCS, glucosylceramide synthase GlcCer, glucosylceramide global health glucosylceramide glucosylceramide synthase GZ-161, GENZ-667161 GZ-346, Genz-123346 H1N1 Health host cell host cell membrane host cell membranes Infection Influenza Influenza virus inhibit inhibitor life cycle life cycles limit LSD, lysosomal storage disease MDCK, Madin–Darby Canine Kidney membrane MOI, multiplicity of infection NB-DNJ, N-butyl–DNJ not applicable outcomes Phase III clinical trials PR8, influenza virus A/PR/8/34 (H1N1) Prevent Replication replication of SARS-CoV-2 respiratory SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus SI, selective index specific inhibitor specific inhibitors sphingolipids Support synthesis the United State therapeutic target Treatment United States Vaccine venglustat Viral viral life cycle virus viruses
[DOI] 10.1016/j.jbc.2021.100470 PMC 바로가기 [Article Type] Accelerated Communication

Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease

SARS 코로나바이러스 2 파파인 유사 프로테아제에 대한 새로운 억제 스캐폴드를 추구하기 위해 인실리코 파이프라인 기반 유사체 구축

Article

Published on 2021-02-202022-09-10
Journal: Molecules [Category] MERS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogue analogues approved AutoDock AutoDock tools binding affinities binding affinity caused comparable Compound conducted Consequences coronavirus COVID-19 crystal structure cysteine cysteine proteases docked docking drug Drug discovery drug-likeness electrostatic Enamine Establishing fatality feature identify in silico in vitro inhibit inhibitor inhibitors Interaction knowledge lack Ligand M pro molecular docking novel outbreak pandemic Papain Papain-like protease performed PL^pro predicted profiles protease protein-ligand interaction Region Replication respiratory SAR SARS coronavirus 2 SARS coronaviruses SARS-CoV-1 SARS-CoV-2 scaffold hopping severe acute respiratory syndrome Coronavirus similarity targets Viral viral replication Virtual screening
[DOI] 10.3390/molecules26041134 PMC 바로가기 [Article Type] Article

Immediate Effects of a Telerehabilitation Program Based on Aerobic Exercise in Women with Fibromyalgia

Article

Published on 2021-02-202022-10-30
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS,

Action of Dipeptidyl Peptidase‐4 Inhibitors on SARS‐CoV‐2 Main Protease

Communication

Published on 2021-02-172022-10-31
Journal: ChemMedChem [Category] COVID-19, SARS,

[키워드] Action analogue Analysis approved binding blocked catalytic activity COVID‐19 COVID19 docking DPP-4 drug candidate Drug repurposing enzymatic assay functional inactive inhibitor inhibitors linagliptin M pro main protease (M^pro) pandemic protease SARS-CoV-2 SARS‐CoV‐2 suggested
[DOI] 10.1002/cmdc.202000921 PMC 바로가기 [Article Type] Communication

Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

Article

Published on 2021-02-112022-10-04
Journal: Scientific Reports [Category] 치료제,

Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues

Review

Published on 2020-12-312022-10-27
Journal: BioMed Research International [Category]

Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues

바이러스 감염 중 MAPK 캐스케이드에 대한 분자적 통찰력: HCQ와 HCQ 유사체 간의 잠재적인 누화

Review

Published on 2020-12-312022-09-10
Journal: BioMed Research International [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome coronavirus analogue analogues antimalarial approach approved attacks cascade cause claimed Combination coronavirus country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host host defense Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism mitogen mitogen-activated protein kinase molecular mechanisms molecular pattern molecular patterns Pandemics pathway Potential Protein quinoline receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Transcription transducing Treatment variety Viral viral infection viral infections Virus Disease
[DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review

Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues

Review

Published on 2020-12-312022-10-27
Journal: BioMed Research International [Category] COVID-19, MERS, SARS,

Different types of physical activity are positively associated with indicators of mental health and psychological wellbeing in rheumatoid arthritis during COVID-19

Observational Study

Published on 2020-11-302022-10-04
Journal: Rheumatology International [Category] MERS, SARS, 임상,