Latex Microsphere-Based Bicolor Immunochromatography for Qualitative Detection of Neutralizing Antibody against SARS-CoV-2Communication Published on 2022-02-072022-10-27 Journal: Biosensors [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] analyzed angiotensin-converting enzyme 2 antibody approach avoidance binding domain carried clinically conditions detection Effectiveness functions immune system Infection Interaction Interpretation lateral flow immunoassay Latex latex microspheres LFIA limit of detection microsphere neutralizing antibody point-of-care positive Qualitative RBD Receptor binding domain reduce risk SARS-CoV-2 SARS-CoV-2 detection serum serum sample Severe infection stimulate the S1 subunit the spike protein vaccination were used [DOI] 10.3390/bios12020103 PMC 바로가기 [Article Type] Communication
CTD of SARS-CoV-2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separationSARS-CoV-2 N 단백질의 CTD는 상분리를 조절하는 데 상호작용하는 ATP 및 핵산 결합을 위한 비밀 도메인입니다Article Published on 2022-02-012022-09-11 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] affinity anti-SARS-CoV-2 ATP ATP: Nucleic acid bind binding binding domain cellular Complete Concentration Critical CTD domain drug target function generate gRNA host cell interface intrinsically life cycle liquid-liquid phase separation (LLPS) living cell modulating MOST N protein NMR NMR spectroscopy NTD nucleic acid nucleocapsid nucleocapsid (N) protein. offer pandemic probe Protein regions representing residue Result SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-CoV-2 variants structures target targets the SARS-CoV-2 unique variant viral life cycle virus [DOI] 10.1002/pro.4221 PMC 바로가기 [Article Type] Article
Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal포르투갈에서 확인 된 SARS-COV-2의 고주파 돌연변이를 갖는 슈도 바이러스의 감염성 및 항원 성Original Article Published on 2022-01-272022-09-10 Journal: Archives of Virology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus antibodies antigenicity B.1.1.7 binding domain caused cell line coronavirus Cross-species transmission D614G Effectiveness Efficacy Epidemic epidemiological Epidemiological investigation evade evaluated hACE2 Health host immunity Huh7 immunized infect Infectivity monoclonal antibodies monoclonal antibody mouse serum mutant mutant strain Mutant strains mutants Mutation N439K N501Y neutralization activity Neutralizing activity nine overexpressing Portugal Prevalence Prevention and control pseudovirus pseudoviruses Receptor binding domain reduced Region regions respiratory S477N SARS-CoV-2 SARS-CoV-2 mutation severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spike protein Spread strain Strains supplementary material susceptible cell tested Vaccine Vaccines Variation Vero was performed was used weakened were used [DOI] 10.1007/s00705-021-05327-0 PMC 바로가기 [Article Type] Original Article
Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study한국에서 첫 12주 동안 BNT162b2 mRNA 백신 2차 접종에 대한 항체 반응: 전향적 종단 연구Article Published on 2022-01-242022-09-12 Journal: Vaccine [Category] SARS, 진단, [키워드] acute respiratory syndrome Analysis anti-RBD antibody Antibody Response binding binding domain BNT162b2 BNT162b2 mRNA vaccine coronavirus declined decrease hospital initial inter-individual interquartile range IQR Korean less median neutralising antibody Older participant Pfizer/BioNTech positive correlation produced Receptor binding domain SARS-CoV-2 second dose severe acute respiratory syndrome coronavirus 2 significantly South Spearman the antibody the antibody response vaccination Variation [DOI] 10.1016/j.vaccine.2021.12.012 PMC 바로가기 [Article Type] Article
Quantum optical immunoassay: upconversion nanoparticle-based neutralizing assay for COVID-19양자 광학 면역 분석 : COVID-19에 대한 상향 전환 나노 입자 기반 중화 분석Article Published on 2022-01-242022-09-01 Journal: Scientific Reports [Category] 진단, 치료기술, 치료제, [키워드] a glass ACE-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody binding domain Biological physics coated with confocal microscope COVID-19 detect dynamic range fluorescent glass high affinity IgG antibody Infection infections Nanoparticles Nanoscale biophysics Neutralizing neutralizing antibody optical Optical sensors pandemic Particle Particles population immunity Prevent Protein quantum reduction in required SARS-CoV-2 receptor SARS-CoV-2 virus sensitivity severity substrate target cells the SARS-CoV-2 virus therapeutic vaccination Viral virion virus was used [DOI] 10.1038/s41598-021-03978-2 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of the Third Booster Dose with Inactivated, Viral Vector, and mRNA COVID-19 Vaccines in Fully Immunized Healthy Adults with Inactivated VaccineArticle Published on 2022-01-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addition administration adverse events anti-RBD AZD1222 binding domain BNT162b2 booster booster dose booster response booster vaccination clinical trial CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 vaccine dose doses healthcare healthy IgA IgG immunogenicity Inactivated vaccine indicated individual Infection mRNA mRNA vaccine neutralization activity outbreak pandemic Patient platform proportion RBD receiving Safe Safety SARS-CoV-2 secreting Serious Adverse Events serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significant increase Spread T-cell Response third dose vaccination Vaccines variant vector Viral vector Viral vector vaccine wild-type [DOI] 10.3390/vaccines10010086 PMC 바로가기 [Article Type] Article
Persistence of Anti-SARS-CoV-2 Antibodies in Long Term Care Residents Over Seven Months After Two COVID-19 Outbreaks두 번의 COVID-19 발생 후 7개월 동안 장기 요양 시설 입소자의 항 SARS-CoV-2 항체 지속성Immunology Published on 2022-01-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료법, [키워드] 229E Analysis Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike antibody antibody levels approved attack rate binding domain Canada Care carried changes in collected comparison COVID-19 COVID-19 outbreak cross reaction demonstrated evaluate finding Gradual HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 human coronavirus human coronavirus (HCoV) humoral humoral immune response Humoral response humoral responses individual individuals Long long term Long term care facilities median MONITOR monitors Month multiplexed immunoassay NL63 nucleocapsid OC43 outbreak Outbreak investigation outbreak investigations Outbreaks over participant participated performed platform provided public health RBD reaction Receptor binding domain Reinfection resident SARS-CoV-2 serologic test serologic testing serologic tests serological serological survey Serological surveys seronegative seropositive seropositive individual serostatus serum serum sample serum samples Seven Spike protein Spike proteins statistical analyses statistically significant survey term the spike protein were used [DOI] 10.3389/fimmu.2021.775420 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults젊은 스웨덴 성인에 대한 인구 기반 연구에서 SARS-CoV-2에 특이적인 B 및 T 세포 면역Clinical Trial Published on 2022-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age allergy assessment Asthma Asymptomatic asymptomatic infections Barn binding domain birth cohort body mass body mass index cellular immunity Characteristics Cohort conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease detectable disease Effects ELISA ELISPOT Factor Follow-up Health humoral humoral and cellular immunity IgA IgE IgG IgG titer IgG titers IgM Immunity IMPROVE indicate individual Infection memory B memory B cells memory response memory T memory T cells Mild mild to moderate mild to moderate disease milieu moderate disease participant population-based cohort positive public transport respiratory rhinitis risk Risk factors SARS-CoV-2 SARS-COV-2 infection seronegative seropositive seropositive subject Seropositivity severe acute respiratory syndrome Coronavirus Sex smoking specific IgM subject subjects subpopulation subset Swedish Symptom symptomatic and asymptomatic T cells T-cell T-cell immunity T-cell Response T-cell responses Transport vaccination whom young adults [DOI] 10.1016/j.jaci.2021.10.014 PMC 바로가기 [Article Type] Clinical Trial
Resistance of SARS-CoV-2 beta and gamma variants to plasma collected from Canadian blood donors during the spring of 20202020년 봄 동안 캐나다 헌혈자로부터 수집된 혈장에 대한 SARS-CoV-2 베타 및 감마 변이체의 내성Article Published on 2022-01-012022-09-11 Journal: Transfusion [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Abbott Abbott Laboratories Aliquots Analysis Anti-spike Architect Beta beta VoCs binding domain blood donor Blood donors can be used can not clinical trial collected cross-sectional cross-sectional design enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays First wave IgG Immunity inhibition assay lentivirus neutralization neutralization capacity neutralization test neutralize neutralizing capacity Neutralizing titer pandemic pilot study plaque reduction neutralization Plaque reduction neutralization test plasma Preliminary data PRNT Protein pseudotyped Qualitative random reduced repeated resistance SARS CoV-2 SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant service specimen the SARS-CoV-2 variant VoC VOCs was performed was used wild-type SARS-CoV-2 [DOI] 10.1111/trf.16713 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Neutralization in Convalescent Plasma and Commercial Lots of Plasma-Derived Immunoglobulin회복기 혈장 및 혈장 유래 면역글로불린 상업 로트에서의 SARS-CoV-2 중화Article Published on 2022-01-012022-09-12 Journal: BioDrugs : clinical immunotherapeutics, biopharmac [Category] MERS, SARS, 진단, [키워드] analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody average binding domain Comorbidity Concentration convalescent convalescent plasma Course COVID-19 COVID-19 pandemic D614G determine Donor effective ELISA Final heterogeneous population high variability humoral IgG immunization immunodeficiency Immunoglobulin increase in indicated intravenous investigated lot-to-lot variability maximum microneutralization neutralization neutralization capacity Neutralizing Neutralizing antibody titer neutralizing capacity normalized Patient patient population patients pharmacokinetic PID plasma produced profile Protective question RBD reactivity Research Result SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 neutralization serological Standard Support tested the WHO vaccination while [DOI] 10.1007/s40259-021-00511-9 PMC 바로가기 [Article Type] Article