Real-time diagnosis and Gleason grading of prostate core needle biopsies using nonlinear microscopy Research Published on 2021-11-022022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] 바이오마커, [키워드] Analysis Anxiety average benefit biopsies biopsy calculated collected Confidence intervals diagnose Diagnosis evaluated FFPE fluorescence microscopy fluorescent formalin-fixed paraffin-embedded genitourinary gold standard GRADE group H&E High-resolution histologic histology investigated Microscopy MRI NLM nuclear pathologist Pathologists Patient patients populations processed Prostate Rapid real time reduce Research sectioning sensitivity similarity specificity specimen subsequent tissue tissue analysis were recorded were stained [DOI] 10.1038/s41379-021-00960-1 [Article Type] Research
The Influence of SARS-CoV-2 Pandemic in the Diagnosis and Treatment of Cervical DysplasiaArticle Published on 2021-10-142022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] Admission All the patient applied biopsy Cancer Cervical clinically colposcopy COVID-19 pandemic decrease Diagnosis disease dysplasia Emergency examined Gynecology histopathological hospital Hospitalization incidence include infected with SARS-CoV-2 influence invasive lesion management material morphopathology pandemic pathological Patient Result Retrospective study reveal risk Romania SARS-CoV-2 Severe case the SARS-CoV-2 took place Treatment [DOI] 10.3390/medicina57101101 PMC 바로가기 [Article Type] Article
Elevated Neutrophil Gelatinase-Associated Lipocalin Is Associated With the Severity of Kidney Injury and Poor Prognosis of Patients With COVID-19Clinical Research Published on 2021-10-082022-10-04 Journal: Kidney International Reports [Category] 바이오마커, [키워드] Acute kidney injury Acute tubular injury Admission AKI analyzed baseline Biomarker biopsy Blood collected Columbia University Comorbidities consecutive patient COVID-19 COVID-19 infection diagnose Diagnosis diagnostic dialysis elevated ELISA enrolled enzyme-linked immunosorbent Hospital admission Hospitalization implicated In-hospital death Infection Injury interquartile kidney Kidney biopsy Kidney function Kidney injury KIM1 Loss marker median molecular mRNA expression need for dialysis neutrophil New York NGAL Odds ratio outcomes pandemic Patient Poor Predictive prospective cohort Result risk RNA SARS-CoV-2 sensitivity serum creatinine severity Shock specificity Stage stages tested the patient Urine with COVID-19 [DOI] 10.1016/j.ekir.2021.09.005 PMC 바로가기 [Article Type] Clinical Research
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19중요한 COVID-19에서 항체 및 보체 의존성 폐렴 손상과 관련된 향상된 호산구 매개 염증Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation adaptive immune responses addition airway airways antibody Antibody Response biopsy complement Complement activation complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients Critical disease disease pathogenesis driver enhanced eosinophil evidenced Fcγ receptor FcγR hallmark immune immune complex Immune complexes immune responses Inflammation innate immune responses lung lung biopsies mechanism membrane myeloid cell myeloid cells pandemic Pathogenesis Pneumonia receptor respiratory respiratory specimen respiratory specimens SARS-CoV-2 SARS-COV-2 infection Signaling subsequent T helper vasculature Viral Viral pneumonia [DOI] 10.1016/j.celrep.2021.109798 PMC 바로가기 [Article Type] Article
Angiotensin‐Converting Enzyme 2 (SARS‐CoV‐2 receptor) expression in human skeletal muscle인간 골격근에서의 안지오텐신 분비 효소 2 (SARS -COV -2 수용체) 발현Original Article Published on 2021-10-042022-09-01 Journal: Scandinavian Journal of Medicine & Science in Spor [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 expression ACE2 protein Adiposity age analyzed angiotensin association biopsies biopsy body composition body fat cardiorespiratory cardiorespiratory fitness collected COVID‐19 determine determined by DXA enzyme exercise explained Express expression fat Interaction lean mass leg legs low fat men men and women Multiple Multiple regression analysis obesity positive Predictive Predictive value Previous studies previous study protein expression receptor regression analysis SARS‐CoV‐2 Sex difference sex differences sexual dimorphism Skeletal muscle slope subject Variability variance vastus lateralis vastus lateralis muscle VO2max was determined was reduced weight western blot women [DOI] 10.1111/sms.14061 PMC 바로가기 [Article Type] Original Article
Prioritizing breast imaging services during the COVID pandemic: A survey of breast imaging facilities within the Breast Cancer Surveillance ConsortiumCOVID-19 팬데믹 기간 동안 유방 영상 서비스의 우선 순위: 유방암 감시 컨소시엄 내 유방 영상 시설에 대한 조사Article Published on 2021-10-012022-09-11 Journal: Preventive medicine [Category] SARS, 치료기술, [키워드] biopsy Breast Breast cancer Breast imaging Cancer screening Characteristics Clinical practice COVID COVID-19 COVID-19 pandemic diagnostic Diagnostic imaging evaluate Factor Health services research Healthcare delivery imaging examination mammography pandemic Patient Preventive services radiology reduced reported risk factor Risk factors Screening suspicion the United State The United States United States [DOI] 10.1016/j.ypmed.2021.106540 PMC 바로가기 [Article Type] Article
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cellsArticle Published on 2021-09-232022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Activation anti-TNF Apoptosis autoinflammatory disease biochemical biopsy canonical CASP8 caspase caspase-8 cell death Cell death and immune response contribute Critical Crohn's disease Crohn’s disease cytokine death dependence driven by driver epithelial Ex vivo feature Genetic Gut Host IBD IEC IFN-γ immunopathology independent induce Inflammatory bowel disease inhibitor interferons intestinal epithelial cell Intestinal Organoids involved JAK inhibitor kill killing kinase loss-of-function mechanisms MLKL mucosal necroptosis Organoid pathway required retained sustained synergistic T cells therapeutic efficacy TNF-α TNFR1 Tumour-necrosis factors ZBP1 [DOI] 10.1038/s41419-021-04151-3 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium선입견 인간 자궁 내막에서 SARS-CoV-2 세포 진입 인자의 단일 세포 RNA 시퀀싱Article Published on 2021-09-182022-09-11 Journal: Human reproduction (Oxford, England) [Category] SARS, 치료기술, [키워드] ACE2 Analysis ANPEP Asymptomatic COVID-19 Biohub biopsy board BSG canonical carriers caution CD209 Cell cell entry cell type cells chance CLEC4G Cohort conducted COVID-19 CTSB CTSL dataset Donor during pregnancy early pregnancy Efficiency epithelial cell epithelial cells European examined expressed expression expression of gene Factor Focusing framework furin Gene Expression Gene Expression Omnibus head healthy Horizon IFITM1 implication Infection Innovation luminal LY6E menstrual menstrual cycle Miguel NCBI NRP1 offer Pregnancy processed Program proliferative Proteases protein expression raw data receptor receptor ACE2 reported reproductive resource reveal risk risk of infection RNA sequencing SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 receptor scRNAseq Sequence Read Archive single-cell level Single-cell RNA-sequencing Spanish Stanford stromal cells supported the SARS-CoV-2 tissue TMPRSS11A TMPRSS2 TMPRSS4 transcriptomics transmission of SARS-CoV-2 Type union vertical transmission viral infection virus [DOI] 10.1093/humrep/deab183 PMC 바로가기 [Article Type] Article
Fine Needle Aspiration Biopsy Case Volumes: A Two-year Analysis of FNA biopsy Diagnostic Categories During the COVID-19 PandemicConference abstract Published on 2021-09-012022-10-05 Journal: Journal of the American Society of Cytopathology [Category] 진단, [키워드] aspiration biopsy COVID-19 needle [DOI] 10.1016/j.jasc.2021.07.106 [Article Type] Conference abstract
Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia인간 비강 상피에서 주요 SARS-CoV-2 진입 인자의 연령 및 기도 질환 관련 유전자 발현 패턴Article Published on 2021-09-012022-09-11 Journal: Virology [Category] SARS, 바이오마커, [키워드] ACE2 Affect age AGTR2 airway biopsy caused Course COVID-19 pandemic differential expression disease disease course downregulation epithelia examined expression of SARS-CoV-2 Factor Gene Expression gene expression pattern inverse correlation mucosal nasal NRP1 Patient patient groups SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 entry factors susceptibility the disease TMPRSS2 underlie [DOI] 10.1016/j.virol.2021.05.012 PMC 바로가기 [Article Type] Article