The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients돼지에서 대사 증후군의 심장 분자 설정은 질병 감수성을 나타내며 환자에서 Covid-19 결과를 악화시키는 메커니즘을 제안합니다.Article Published on 2021-10-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] aggregation Analysis animal model Arterial thrombosis association Blood blood test blood tests capture cardiovascular disease cardiovascular diseases change Comorbidity Complement pathway component components computational analysis COVID-19 CVD deregulation develop diabete diabetes disease elevated enriched pathway enzyme exacerbate expressed greater hallmark hallmarks hypertension identity immune response investigated mechanism metabolic syndrome metabolite metabolites metabolomics molecular Myocardial Myocardium obese obesity outcome overexpressed pathophysiology Patient patients patients with COVID-19 PIGS Platelet platelet aggregation pro-inflammatory pro-inflammatory markers Protein proteomics reveal risk risk factor Risk factors RNA methylation susceptibility syndrome Therapeutic approach thrombosis transcriptomics virus viruses while [DOI] 10.1038/s41598-021-99143-w PMC 바로가기 [Article Type] Article
Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months6개월 동안 입원부터 회복까지 COVID-19 환자의 SARS-CoV-2 유도 체액 면역 반응의 지속 가능성Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] MERS, SARS, 진단, 치료기술, [키워드] acquired immunity age all the patients analyzed anti-SARS-CoV-2 antibody capture chemiluminescence immunoassay CLIA convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients Convalescent patients coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 antibody COVID-19 patient COVID-19 symptoms detect dynamic exhibit Gender group help herd immunity Hospitalization Hospitalized humoral immune response humoral responses IgG antibody IgM IgM antibodies IgM/IgG Immunity induced investigated Month N protein observation over Patient peaked persistence positive Receptor binding domain reduced reducing Reinfection response retrospective cohort study risk S protein SARS-CoV-2 SARS-COV-2 infection serum sample serum samples severity specimen sustainability sustained the patient titers titers of IgG understanding undetectable vaccination Wuhan [DOI] 10.1007/s12250-021-00360-4 PMC 바로가기 [Article Type] Article
COVIDrugNet: a network-based web tool to investigate the drugs currently in clinical trial to contrast COVID-19Covidrugnet : Covid-19를 대조하기 위해 현재 임상 시험에있는 약물을 조사하는 네트워크 기반 웹 도구Article Published on 2021-09-302022-09-10 Journal: Scientific Reports [Category] 신약개발, 임상, 치료기술, 치료제, [키워드] Analysis approach capture clinical trial Consistency COVID-19 COVID-19 pandemic drug Drug discovery drug-target effective Evidence example help implementation implication IMPROVE Infection Medicine Medicines Network topology Networks and systems biology online tool pharmacological probe public health Research SARS-COV-2 infection starting the SARS-CoV-2 Therapies Treatment treatment of COVID-19 unmet need web application [DOI] 10.1038/s41598-021-98812-0 PMC 바로가기 [Article Type] Article
Computational workflow for functional characterization of COVID-19 through secondary data analysis보조 데이터 분석을 통한 CovID-19의 기능적 특성화를위한 계산 워크 플로Protocol Published on 2021-09-242022-09-10 Journal: STAR protocols [Category] SARS, 유전자 메커니즘, [키워드] Abstract Analysis association bioinformatics can not capture Complete complexes COVID-19 Data analysis disease feature functional Gene Expression Genomics Health Sciences heterogeneous identify immunology interactions Meta-analysis molecular mechanism molecular mechanisms multiple model systems network network analysis other diseases outcomes pathophysiological pathophysiology protein interaction protein interactions protocol RNAseq Single Cell single-cell RNA-seq Standard step Systems biology transcriptional transcriptomic underlying disease [DOI] 10.1016/j.xpro.2021.100873 PMC 바로가기 [Article Type] Protocol
A Novel Smart City-Based Framework on Perspectives for Application of Machine Learning in Combating COVID-19Covid-19Review Published on 2021-09-112022-09-10 Journal: BioMed Research International [Category] 치료기술, [키워드] addition Algorithm application approach capture case studies component COVID-19 COVID-19 pandemic curtail detect effort framework generate globe Healthcare system help hospital Internet Internet of Things interoperability lockdown machine machine learning machine learning algorithm Machine learning algorithms machine learning model machine learning models multidimensional National novel outcome outlined Prevent promote Research SmaRT smart cities Spread spread of COVID-19 the disease Treatment triggered [DOI] 10.1155/2021/5546790 PMC 바로가기 [Article Type] Review
Snowball Sampling Study Design for Serosurveys Early in Disease Outbreaks질병 발생 초기 혈청 처리를위한 눈덩이 샘플링 연구 설계Observational Study Published on 2021-09-082022-09-10 Journal: American journal of epidemiology [Category] 임상, 치료기술, [키워드] Analysis association Asymptomatic asymptomatic infection asymptomatic infections capture Characteristics Contact Contact tracing coronavirus disease Coronavirus disease 2019 COVID-19 design effect disease severity early stage early stages estimation Evidence evidence of Host individuals infected cases Infection infection rate information observational study outbreak pandemic Pandemics parameters Probability proportion question Sample size sampling SARS-CoV-2 serological survey Serological surveys seropositive Seropositivity serosurvey sampling Snowball Spectrum Study design transmission chain [DOI] 10.1093/aje/kwab098 PMC 바로가기 [Article Type] Observational Study
Evaluation of a SARS-CoV-2 Capture IgM Antibody Assay in Convalescent Sera회복기 혈청에서 SARS-CoV-2 포획 IgM 항체 분석 평가Research Article Published on 2021-09-082022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alternative method antibody antibody duration capture capture IgM ELISA coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical death decrease detect diagnosing Diagnosis diagnostic disease domain ELISA ELISAs ENhance enzyme-linked immunosorbent enzyme-linked immunosorbent assay global pandemic Health care health care systems IgG IgG antibodies IgG antibody IgG ELISA IgM IgM antibodies IgM antibody Infection less life nucleocapsid patients PCR PCR-positive positive Prevalence Protein Proteins RBD RBD ELISA reached receptor Receptor-binding domain reported respiratory responsible SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike Sensitivity and specificity serological response serology serum serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Specificities specificity the RBD the receptor-binding domain the SARS-CoV-2 Transmission dynamics understanding undetectable vaccination while Wuhan Wuhan, China [DOI] 10.1128/Spectrum.00458-21 PMC 바로가기 [Article Type] Research Article
Targeted Hybridization Capture of SARS-CoV-2 and Metagenomics Enables Genetic Variant Discovery and Nasal Microbiome InsightsResearch Article Published on 2021-09-012022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Alter Analysis approach average Better capture clinically coronavirus COVID-19 defined detect diagnostics DNA double-stranded drug dsDNA Emergency use authorization Evidence FDA food Genetic Genetic variant Genome highlight Hybrid capture hybridization IMPROVE Infectious disease insight limit of detection metagenomics Microbiome molecular mutations nasopharyngeal Next-generation sequencing NGS Outbreaks pathogen polymerase chain positive Precision probes reverse transcription risk stratification RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral SARS-CoV-2-positive patients Spike protein Surveillance the SARS-CoV-2 genome the SARS-CoV-2 virus therapeutic therapeutic options urgency Vaccine variants viral evolution viral fitness viral genomics widespread [DOI] 10.1128/Spectrum.00197-21 PMC 바로가기 [Article Type] Research Article
Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individualsSARS-CoV-2 게놈 및 COVID-19 개인의 서브게놈 단편의 올리고뉴클레오티드 캡처 시퀀싱Research Article Published on 2021-08-252022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] allelic approach capture capture sequencing cause CDC clinical sample clinical samples Complete coronavirus disease Coronavirus disease 2019 COVID-19 Cycle threshold value effective facilitate Frequency full-length genome functional generate Genome genomic hybridization individual infected patients junction methodology mixture offer oligonucleotide oligonucleotide probe Open reading frame ORF1ab gene ORFs Patient qPCR assay Region representing RNA SARS-CoV-2 sequence Sequencing subpopulation suggested the SARS-CoV-2 genome transcriptional activity Transcriptome Viral load viral RNA species viral RNA specy [DOI] 10.1371/journal.pone.0244468 PMC 바로가기 [Article Type] Research Article
Use of research electronic data capture (REDCap) in a COVID-19 randomized controlled trial: a practical exampleCOVID-19 무작위 대조 시험에서 연구 전자 데이터 캡처 (REDCAP) 사용 : 실제 예Research Article Published on 2021-08-212022-09-10 Journal: BMC Medical Research Methodology [Category] Fulltext, MERS, SARS, 임상, [키워드] allocation sequence Antibody test Blinding can be used capture changed Complete component conducted confidentiality Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 Data collection defect Efficacy eligibility example feature Follow-up investigator investigators lab Longitudinal data offer parallel group powerful tool Protective protocols randomization Randomized Randomized controlled trials RCT RCTs receiving recruitment REDCap Registered Registration registration number reported Research Research Electronic Data Capture researcher Result Risk of bias SARS-CoV-2 antibody test secure supplementary material test results treatment arm Trial registration unique university web application XML [DOI] 10.1186/s12874-021-01362-2 PMC 바로가기 [Article Type] Research Article