cascade – Page 7 – Communicable Diseases Research

The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses

MEK1/2 억제제 ATR-002는 SARS-CoV-2 전파를 효율적으로 차단하고 전염증성 사이토카인/케모카인 반응을 완화합니다

Original Article

Published on 2022-01-102022-09-10
Journal: Cellular and Molecular Life Sciences [Category] 치료제,

Cognitive cascades: How to model (and potentially counter) the spread of fake news

Research Article

Published on 2022-01-072022-10-28
Journal: PLoS ONE [Category] Coronavirus, SARS,

[키워드] aggregate Analysis approach cascade cascades cognitive Cognitive function diffusion disease spread Effect epidemiologists expressive increasingly individual Interaction lack media Mental network outcome POD rejection reported researcher Spread structures Topology understanding
[DOI] 10.1371/journal.pone.0261811 PMC 바로가기 [Article Type] Research Article

The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders

심각한 COVID-19 및 관련 장애에서 DAMP 매개 염증의 영향

Review

Published on 2022-01-012022-09-12
Journal: Biochemical pharmacology [Category] MERS, SARS, 진단,

SARS-CoV-2 detection in wastewater as an early warning indicator for COVID-19 pandemic. Madrid region case study

COVID-19 전염병에 대한 조기 경고 지표로서 폐수에서 SARS-CoV-2 검출. 마드리드 지역 사례 연구

Article

Published on 2022-01-012022-09-11
Journal: Environmental research [Category] SARS, 치료기술,

[키워드] activate analysed Analysis carried cascade changed Concentration contributed correlated COVID-19 COVID-19 pandemic criteria distribution epidemiological epidemiological surveillance Epidemiology field Genome Health health authorities hospitalisation hotspot incidence rate incidence rates Infection information Interpretation knowledge Laboratory litre methodology outbreak pandemic parameter physicochemical Pilot test Public Public health methodology Result Safe Sample SARS-CoV-2 SARS-CoV-2 detection statistical analysis Surveillance tested to define virus wastewater wastewater-based epidemiology (WBE) WBE
[DOI] 10.1016/j.envres.2021.111852 PMC 바로가기 [Article Type] Article

Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin

Perspective

Published on 2021-12-242022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

[키워드] active cancer acute respiratory distress addition Admission ARDS arising C-reactive protein cascade caused clinical clinical trial Complete COVID-19 COVID-19 illness COVID-GRAM COVID-GRAM score Critical death demonstrated disease dysregulation EudraCT events exhibited high risk hospitalized patient IMPROVE inhibitor intensive care interstitial pneumonia Intervention invasive ventilation knowledge Legalon lymphocytopenia multiorgan failure outcome oxygen support Pathogenesis pathophysiology Patient patients Perspective predicted presenting Proinflammatory response pulmonary lesions receiving recruited required Research SARS-CoV-2 severe COVID-19 Side-effects silibinin STAT3 supportive care syndrome therapy transcriptional treating COVID-19 Treatment
[DOI] 10.3390/ph15010019 PMC 바로가기 [Article Type] Perspective

Physicians’ Experience with COVID-19 Vaccination: A Survey Study

Article

Published on 2021-12-172022-10-31
Journal: International journal for equity in health [Category] COVID-19,

The seven constitutive respiratory defense barriers against SARS-CoV-2 infection

SARS-COV-2 감염에 대한 7 가지 구성 호흡기 방어 장벽

Review

Published on 2021-12-172022-09-01
Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] SARS, 진단,

[키워드] activate adaptive Adaptive immune response adaptive immune responses airway alveoli antibodies antimicrobial peptide antimicrobial peptides Antiviral antiviral activity cascade Cell clearance component Defense Defensins and lactoferrin elicit ENhance epithelial cell Epithelial cell interferons epithelial cells functions Gas exchange IgA antibodies immune Immune cell immune cells immune responses immunomodulatory molecule Infection infectious agents Inhaled inhibit inhibit SARS-CoV-2 Innate immunity interferons Invasion lactoferrin Local luminal luminal surface mechanisms microbiota modulate Mucociliary clearance Mucus noxious overcome Particles pathogen peptides phagocytes receptor receptors regulate respiratory respiratory epithelial cells respiratory tract Respiratory tract microbiota respiratory viruses SARS-CoV-2 SARS-COV-2 infection secretory secretory IgA Seven subject surface tension Surfactant proteins tension these cell These cells Viral virus
[DOI] 10.1590/0037-8682-0461-2021 PMC 바로가기 [Article Type] Review

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics

가상 스크리닝 및 필수 역학에 의한 강력한 ACE2 활성화제로서의 담즙산 유도체 발견

Article

Published on 2021-12-162022-09-10
Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료제,

[키워드] ACE2 ACE2 expression acid activator addition angiotensin Angiotensin-converting enzyme approach assumed bile binding biochemical cascade Clinical prognosis comparable Compound contributing to COVID-19 COVID-19 disease derivative Diseases docking downregulate Dynamics enzyme Essential event Host host cell in silico in vitro Inflammation Interaction late stage leads life cycle ligands lung mechanism of action molecular molecular dynamics oxidative stress pharmacological potent provide receptor reduction regulated Regulation SARS-CoV-2 SARS-COV-2 infection Screening Spike protein the spike protein therapeutic potential Trigger triggers Ursodeoxycholic acid vessel Viral viral spike protein Virtual screening virus
[DOI] 10.1021/acs.jcim.1c01126 PMC 바로가기 [Article Type] Article

Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial Inflammation

SARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성

Research

Published on 2021-12-152022-09-10
Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured
[DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research

The protective role of vitamin C in the management of COVID-19: A Review

Review

Published on 2021-12-112022-10-30
Journal: Journal of the Egyptian Public Health Association [Category] COVID-19,