CD19 – Page 7 – Communicable Diseases Research

Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19

종단 임상 및 방사선 사진 평가에서 코로나19의 지속적인 폐 손상의 지표로 인터루킨-6이 밝혀졌습니다.

Research Paper

Published on 2021-01-012022-09-10
Journal: International Journal of Medical Sciences [Category] MERS, 바이오마커,

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial

B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19

SARS-CoV-2 대 말라리아의 B 세포 분석: 코로나19에서 형질모세포 및 비정형 기억 B 세포의 빈도 증가

Clinical Trial

Published on 2021-01-012023-07-13
Journal: Journal of leukocyte biology [Category] SARS, 말라리아,

[키워드] CD19 CD39 CD73 hyperinflammation
[DOI] 10.1002/JLB.5COVA0620-370RR [Article Type] Clinical Trial

B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients

COVID-19 환자의 중증도 관련 시그니처로서의 B 세포 하위 집합

Clinical Trial

Published on 2020-12-032022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] accompanied adaptive antiviral response affected Analysis antibody-secreting cell antibody-secreting cells approach association B cell B cell subset B cell subset frequencies B cell subsets B cell subsets frequencies B cells Biomarkers biomarkers of inflammation CD19 change changes in circulating clinical and laboratory parameters Clinical data Cluster cluster analysis correlated correlation correlations Course COVID-19 COVID-19 patients critical cases decrease disease course disease severity DN B cells double-negative B cell double-negative B cells exhibited feature Frequency Health health problem Hierarchical hierarchical cluster analysis Host immune response identify immature increase in laboratory parameter Laboratory parameters lymphocyte Lymphocytes memory memory B cells Memory B compartment mild cases mounted multiparametric flow cytometric multiparametric flow cytometric approach Other participant Patient Potential biomarker potential biomarkers respiratory respiratory parameters Result SARS-CoV-2 SARS-COV-2 infection severe and critical cases severe COVID-19 severity severity of COVID-19 signature Specific subpopulations subset terminally differentiated the disease transitional B cell transitional B cells with COVID-19
[DOI] 10.3389/fimmu.2020.611004 PMC 바로가기 [Article Type] Clinical Trial

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] COVID-19,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Circulating Cytokines and Lymphocyte Subsets in Patients Who Have Recovered from COVID-19

Research Article

Published on 2020-11-262022-10-27
Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] Alpha Analysis analyzed B cell B cells CD19 CD3 CD4 CD56 CD8 circulating Cohort Concentration consequence correlation COVID-19 COVID-19 infections cytokine decrease discharge Efficacy flow cytometry growth factor healthy controls hospital Hyperinflammatory IFN IL-10 IL-17 IL-2 IL-4 IL-6 IL-8 Immune status immune system increases in independent predictor Infection interferon gamma longitudinal study lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Necrosis NK cell NK cells observation Patient patients positively correlated recovered recovered patient recruited rehabilitation remained ROC Curve serum significantly higher significantly lower sustained T cell T cells TGF TNF- α
[DOI] 10.1155/2020/7570981 PMC 바로가기 [Article Type] Research Article

Nucleic acid and antibody assay results in Chinese patients with coronavirus disease 2019 (COVID-19)

Article

Published on 2020-10-122022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 진단,

[키워드] age alanine aminotransferase analyzed antibodies antibody antibody production antibody test result C-reactive protein CD19 CD4 CD8 cell count chain Characteristics China Chinese patient clinical coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 creatinine died discharge electronic medical records evaluate group groups IgG antibody IgM IL-6 individual Laboratory Laboratory test laboratory-confirmed SARS-CoV-2 infection lactate dehydrogenase male mild symptoms MOST Nasopharyngeal samples no difference no significant difference nucleic acid nucleic acids Patient patients positive producing Re-positivepatients reaction Result RT-PCR SARS-CoV-2 sputum Stool tested three group Treatment
[DOI] 10.1016/j.intimp.2020.107089 PMC 바로가기 [Article Type] Article

Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals

Research Article

Published on 2020-09-292022-10-31
Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS,

[키워드] abnormal increase acute respiratory syndrome Affect bead C reactive protein caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical severity Comorbidity complement conducted confirmed case coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical CRP cytokine Data analysis decrease demonstrated disease severity effort eligible flow cytometric Frequency global pandemic IFN IgA IgE IgG IgM IL-10 IL-2 IL-4 IL-6 immune system Immunity immunoassay Immunoglobulin Immunologic immunological characteristics immunological parameters Immunological response in both group individual Level lymphocyte subpopulation NDM neutrophil count NK cell no significant difference participant Peripheral blood pilot study proportion Result retrospective risk factor SARS-CoV-2 Sex significantly higher surface marker T2D Th1 cytokine TNF- α two groups Type type 2 diabete virus
[DOI] 10.1155/2020/6914878 PMC 바로가기 [Article Type] Research Article

COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

Research

Published on 2020-08-142022-10-30
Journal: Immunity & Ageing : I & A [Category] COVID-19,

[키워드] ACE2 adaptive age analysed angiotensin-converting enzyme inhibitor Asia average blocker C-reactive protein carried CD19 CD4 CD8 Clinical course cohorts Comorbidities country Course COVID-19 COVID-19 pandemic COVID-19 severity decrease Deleterious diabetes disease dyslipidaemia effectors enzyme European evidenced Fatality rate feature form health authorities hospitalized patient hypertension hypertensive patient immune system Immunity immunological immunosenescence inhibitor innate response interleukin 6 interleukin-6 Laboratory Local lymphocyte Lymphocyte count Lymphocytes male males Mild moderate multicentre natural killer Older outcome Patient Prognosis protective effect public health ranged receptor renin-angiotensin system reported Result Retrospective study risk factor SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severity significantly lower Spain Spanish spread to subpopulation the disease was performed
[DOI] 10.1186/s12979-020-00194-w PMC 바로가기 [Article Type] Research

Clinical Characteristics and Risk Factors for Disease Severity and Death in Patients With Coronavirus Disease 2019 in Wuhan, China

Medicine

Published on 2020-08-132022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Admission age CD19 CD3 CD4 CD4 cell Cell clinical clinical manifestation collected data Comorbidities Comorbidity conducted COVID-19 COVID-19 case Cox model Cytokines D-dimer death Deterioration diabete died disease deterioration elevated Factor Fever High-sensitivity C-reactive protein hypertension IL-10 IL-6 immune response immune responses Inflammation interleukin-10 IQR lactate dehydrogenase LDH Leukocytosis lymphocyte lymphopenia manifestation men Neurological symptom neutrophil Next-generation sequencing Older age organ dysfunction outcome Patient patients Pneumonia progressed progression progression of disease Renmin Hospital respiratory symptom Retrospective study risk factor Risk factors RT-PCR severity statistical analysis the disease the median university Wuhan Wuhan, China
[DOI] 10.3389/fmed.2020.00532 PMC 바로가기 [Article Type] Medicine