Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2
IMMUNOLOGY
[키워드] in vivo protection
ACE2 receptor
adverse event
antibody
binding
block
cellular receptor
characterized
complex
concentrations
conformational change
COVID-19
cryo-EM structure
dose
effective
Fab
Fab fragment
Human monoclonal antibody
human neutralizing antibody
immuno-therapy
Infection
membrane fusion
monoclonal antibody
Mouse models
occlude
postfusion
preclinical safety evaluation
prefusion
Prevent
progression
Receptor binding domain
rhesus macaque
SARS-CoV-2
single dose
subsequent
therapeutic
trimeric
[DOI] 10.1093/nsr/nwaa297 PMC 바로가기 [Article Type] IMMUNOLOGY
[DOI] 10.1093/nsr/nwaa297 PMC 바로가기 [Article Type] IMMUNOLOGY