Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-Resistant Salmonella Strains in Japan일본에서의 확장 스펙트럼 세팔로스포린 내성 살모넬라 균주 저장소로서의 식품 노동자Article Published on 2020-06-172024-08-21 Journal: Applied and Environmental Microbiology [Category] 살모넬라증, [키워드] chromosome CTX-M ESBL ESC food worker ISEcp1 reservoir Salmonella
The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapiesIM-Point of view Published on 2020-05-192022-10-30 Journal: Internal and Emergency Medicine [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” ACE-2 ACE-inhibitors angiotensin II receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB ARBs benefit binding blocker cardiovascular comorbidity cardiovascular disease cardiovascular diseases Cell cell types characterized China chromosome claimed Clinical course Clinical practice coding COVID-19 Deceased diabete disease Disseminated intravascular coagulation downregulation drugs Effect Effects Endothelial cell endothelial cells Endothelium enzyme epidemiological situation Evidence experimental model expressed expression female patient hazard host’s cell humans hypertension implication in vivo Infection intestinal involved Italian kidney molecular Mortality most prevalent comorbidity mRNA Neutral Occurrence Older Patient patients treated patients with COVID-19 Prospective Study protein level question Randomized receptor renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected patients smoking Spike protein subsequent targets therapy Thromboembolism thrombosis tissues TMPRSS2 protease treated Treatment Vasculitis worse prognosis [DOI] 10.1007/s11739-020-02364-6 PMC 바로가기 [Article Type] IM-Point of view
Copy number variants and fixed duplications among 198 rhesus macaques ( Macaca mulatta )198마리의 붉은털 원숭이( Macaca mulatta ) 사이의 복제 수 변종 및 수정된 중복Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] assumption Biomedical research chromosome composed concerning conducted copy copy number copy number variant Copy number variants dataset design of experiments disease risk distribution duplication duplications event Evolution experiment fixed focus functional consequences genetic difference genetic differences Genetic variation Genome genomes genomic genomic region high resolution High-resolution highlight human disease humans individual individuals inter-individual knowledge large sample Old World monkey Old World monkeys one individual organism Organisms orthologs performed Phylogenetic relationship profile reference genome Region regions representing Research rhesus rhesus macaque rhesus macaques sequence similarity species target gene Target genes variable regions Variation [DOI] 10.1371/journal.pgen.1008742 PMC 바로가기 [Article Type] Research Article
A patient with 46,XY/47,XYY karyotype and female phenotype: a case reportCase Report Published on 2020-03-242023-08-29 Journal: BMC Endocrine Disorders [Category] E형 간염, [키워드] 47,XYY chromosome manifestation [DOI] 10.1186/s12902-020-0523-8 PMC 바로가기 [Article Type] Case Report
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders11번 염색체에 있는 새로운 유전자간 변이의 파생된 대립유전자는 그린랜더의 낮은 체질량 지수 및 유리한 대사 표현형과 관련이 있습니다Research Article Published on 2020-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipose Adipose tissue affected affecting Alaska allele alteration Analysis Arctic association Author Beta biological processe biological processes BMI body mass body mass index body-mass body-mass index cholesterol chromosome chromosome 11 Cohort cohorts contribute derived allele expand Fat mass Frequency G allele G-allele Genetic genetic architecture genetic loci Genetic predisposition Genetic variant genetic variants genome-wide significant HDL-cholesterol identify independent insulin insulin resistance knowledge lean mass measure mechanism Meta-analysis Native obesity performed phenotype physical activity populations remained replicate Replication required risk significantly Stage stage 2 study population target targets the stage tissue traits Treatment Triglyceride variant visceral Waist circumference weight were assessed [DOI] 10.1371/journal.pgen.1008544 PMC 바로가기 [Article Type] Research Article
A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivityGWAS 접근 방식은 Dapp1을 대기 오염 유발 기도 과민 반응의 결정 요인으로 식별합니다.Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence AhR air pollutant Air pollution airway airways approach association Asthma Author chromosome chromosome 19 chromosome 3 chromosomes chronic inflammatory disease condition Dapp1 diesel exhaust Diversity exhibited exposure to expressed Factor Genes Genetic genetic architecture genetic determinant genetic determinants genetic factors Genome-wide association studies Genome-wide association study GWAS HMDP Human humans hybrid Hyperreactivity identify IL33 inbred strains inherent Interaction interactions invasive linear mixed model loci locus lung Lung function mapped mice modulate mouse mucosal tissues Panel Particle phenotype risk significantly significantly lower strain Support susceptibility loci while [DOI] 10.1371/journal.pgen.1008528 PMC 바로가기 [Article Type] Research Article
The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep ( Ovis aries )Soay 양의 야생 개체군에서 기생충 특이적 면역 반응의 유전적 구조( Ovis aries )Research Article Published on 2019-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect antibody antibody level antibody levels blood plasma chromosome CIITA class CLEC16A collected complex condition conditions Containing contribute driver Drivers ecological Effect Evidence evidence of Genetic genetic architecture genetic control Genetic variation genomic region heritable variation histocompatibility Host hosts humans identify IgA IgA level IgA levels IgE IgG IgG antibodies IgG antibody IgG level IgG levels IGH immune Immune profile immune response immune responses Immunity Immunoglobulin immunological Infection influence investigated knowledge Laboratory lectin loci maintain Major major histocompatibility complex MHC natural populations natural selection nematodes offer Organisms Ovis parasite parasites Population prevalent provide response sheep significantly the major histocompatibility traits understanding Variation while [DOI] 10.1371/journal.pgen.1008461 PMC 바로가기 [Article Type] Research Article
An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndromeADAMTS3 missense 변종은 Norwich Terrier 상기도 증후군과 관련이 있습니다.Research Article Published on 2019-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADAMTS3 addition affected airway airway obstruction airways Analysis approach association assumed breed Bulldog candidate gene canine caused change characteristic chromosome chromosome 13 contribute Critical determinant determinants disease Disruption dissociate English ENhance error examined ExoN facial feature flat French French bulldog Frequency Genetic genetic association genetic screens genetics Genome genome-wide association Health health screening heterogeneous highlight identify independent independent of Intervention Laryngoscopy loss of function Missense mutation missense variant motif oedema offer overlap pathology performed predisposing factor predisposition presenting prevalent Previous studies previous study prognostics resolved respiratory Respiratory disease respiratory diseases respiratory obstruction risk allele scored screened severity shown skull surgical surgical interventions Symptom syndrome Terrier treat upper upper airway variant variants was used [DOI] 10.1371/journal.pgen.1008102 PMC 바로가기 [Article Type] Research Article
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania실험 하이브리드의 전체 게놈 시퀀싱은 Leishmania에서 감수 분열과 같은 성적 재조합을 지원합니다Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele approach backcross breakpoint Cell Cell fusion chromosomal chromosome chromosomes classical clone Culture demonstrated described determine division event Evidence expected Frequency Gain Genes Genetic genetic analysis genetic map Genome Genotype genus growth heterozygosity heterozygous homologous homologous chromosomes homozygous hybrid instance isolate Leishmania loss of heterozygosity marker meiosis mitotic occur offspring parental parents physical position presenting progeny Recombination sequenced Sequencing sexual cycle species Stage strain Strong Support undergo vector while whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1008042 PMC 바로가기 [Article Type] Research Article