Identification of CD8 + T cell epitopes through proteasome cleavage site predictionsMethodology Published on 2020-12-142022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Accuracy analyzed C-terminal cleavage CD8 CD8+ T cell epitope cleavage cleavage site coefficient dataset epitope Epitopes evaluated Features identification Immunoproteasome introduced peptide predict predicted prediction proteasome Proteins provided random Result SARS-CoV-2 sensitivity server specificity T cell T cell epitope T cell epitopes unique [DOI] 10.1186/s12859-020-03782-1 PMC 바로가기 [Article Type] Methodology
Identification of CD8 + T cell epitopes through proteasome cleavage site predictionsMethodology Published on 2020-12-142022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, MERS, [키워드] Accuracy analyzed C-terminal cleavage CD8 CD8+ T cell epitope cleavage cleavage site coefficient dataset epitope Epitopes evaluated Features identification Immunoproteasome introduced peptide predict predicted prediction proteasome Proteins provided random Result SARS-CoV-2 sensitivity server specificity T cell T cell epitope T cell epitopes unique [DOI] 10.1186/s12859-020-03782-1 PMC 바로가기 [Article Type] Methodology
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulationProblems & Paradigms Published on 2020-11-172022-10-27 Journal: Bioessays [Category] COVID-19, [키워드] Analysis backbone binding ability BtCov/4991 chimeric cleavage site coronavirus Coronaviruses CoV CoVs cross evaluate furin cleavage site Gain‐of‐function studies Genetic genetic manipulation Host human cell Intervention Laboratory Mutagenesis Pandemics pangolin pangolin CoV performed RaTG13 RBD Receptor binding domain Recombination researcher resulting SARS‐CoV‐2 SARS‐CoV‐2 sequence the spike protein tissue virus [DOI] 10.1002/bies.202000240 PMC 바로가기 [Article Type] Problems & Paradigms
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulationProblems & Paradigms Published on 2020-11-172022-10-27 Journal: Bioessays [Category] Coronavirus, COVID-19, SARS, [키워드] Analysis backbone binding ability BtCov/4991 chimeric cleavage site coronavirus Coronaviruses CoV CoVs cross evaluate furin cleavage site Gain‐of‐function studies Genetic genetic manipulation Host human cell Intervention Laboratory Mutagenesis Pandemics pangolin pangolin CoV performed RaTG13 RBD Receptor binding domain Recombination researcher resulting SARS‐CoV‐2 SARS‐CoV‐2 sequence the spike protein tissue virus [DOI] 10.1002/bies.202000240 PMC 바로가기 [Article Type] Problems & Paradigms
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivityNeuropilin-1은 SARS-CoV-2 세포 진입 및 감염을 촉진합니다Report Published on 2020-11-132022-09-14 Journal: Science (New York, N.y.) [Category] MERS, SARS, 유전자 메커니즘, [키워드] abundantly expressed ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 antibody antiviral intervention antiviral therapeutics Autopsy bind blocked Cell Cell culture cellular entry cleavage site cofactor coronavirus coronavirus disease COVID-19 determine endothelial epithelial cells expression facilitate Factor furin furin cleavage site furin-cleaved substrates highest Host host cells inhibitor Interaction involved monoclonal monoclonal antibody mutant nasal Neuropilin-1 NRP1 Olfactory epithelium pathological protease raising reduced SARS-CoV SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection Science significantly Spike protein target the spike protein therapeutic target tissue tropism tissues understanding viral infection virus receptor viruses [DOI] 10.1126/science.abd2985 PMC 바로가기 [Article Type] Report
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2Article Published on 2020-10-102022-10-29 Journal: SLAS discovery : advancing life sciences R & D [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome Antiviral antivirals cell-based cleavage site clinically Confirmed confirmed case coronavirus coronavirus disease COVID-19 death determine disease drug Efficacy evaluate food global pandemic HTS identify Infection inhibitor initiated medical countermeasure Papain-like protease peptide PLPro Prevent reported SARS-CoV-2 Screening selective significantly Small molecules tested the disease the SARS-CoV-2 therapy treat triggered Vaccine [DOI] 10.1177/2472555220963667 PMC 바로가기 [Article Type] Article
Experimental and in silico evidence suggests vaccines are unlikely to be affected by D614G mutation in SARS-CoV-2 spike proteinBrief Communication Published on 2020-10-082022-10-04 Journal: NPJ Vaccines [Category] 변종, [키워드] Affect affected approach cleavage site comparable COVID-19 vaccine D614G mutation dose Efficacy Evidence experimental evidence ferret glycoprotein in silico INO-4800 introduced lack Mutation neutralisation assay performed Proteases RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 spike protein sera shown Spike protein Support supported the SARS-CoV-2 unlikely Vaccine Vaccines viral evolution virus isolate [DOI] 10.1038/s41541-020-00246-8 PMC 바로가기 [Article Type] Brief Communication
Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoproteinArticle Published on 2020-10-052022-10-30 Journal: Journal of Structural Biology: X [Category] COVID-19, [키워드] ab initio modelling abrogated Abstract cleavage site conformations coronavirus furin cleavage site glycan host cells human pathogen insertion Interaction Molecular dynamics simulation prefusion protease proteolytic cleavage regulate representing S1/S2 SARS-CoV-2 spike glycoprotein spike glycoprotein gene Structure the SARS-CoV-2 therapeutic target viral entry virulent [DOI] 10.1016/j.yjsbx.2020.100038 PMC 바로가기 [Article Type] Article
Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactionsResearch Article Published on 2020-09-242022-10-27 Journal: AIMS Microbiology [Category] COVID-19, [키워드] ACE2 attribute C-terminal cleavage Characteristics cleavage cleavage site cleavage sites complex conformational COVID-19 directional docked docking driven by drug target etiological agent full length functional host cell human ACE2 receptor interact Interaction intermolecular interaction molecular molecular docking N-terminal predicted priming provide residue resolved responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein serine protease Spike protein the SARS-CoV-2 the spike protein TMPRSS2 viral spike protein [DOI] 10.3934/microbiol.2020021 PMC 바로가기 [Article Type] Research Article
Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral M pro Protease Target Host Selenoproteins and Glutathione Synthesis?Nutrition Published on 2020-09-022022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] activate Algorithm antioxidant catalytically active cleavage site Clinical outcome component contribute coronavirus correlation COVID-19 cysteine protease Cytokine storm cytosolic deficiency DNA Effect exacerbated expected Factor glutathione Glutathione peroxidase glutathione peroxidase 1 GPx GPX1 inactive Inflammation inhibit knockdown M pro mechanism mutant NF-κB NF-κB activation oxidative stress precursors pro-inflammatory cytokines protease proteolytic rate-limiting enzyme reactive oxygen specy resulting ribonucleotide RNA synthesis SARS-CoV M SARS-CoV-2 Selenium SELENOF selenoprotein sequence shown target thioredoxin reductase transfected cells turn understanding virion production wild-type [DOI] 10.3389/fnut.2020.00143 PMC 바로가기 [Article Type] Nutrition