A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients특정 저밀도 호중구 개체군은 입원한 COVID-19 환자의 과응고 및 질병 중증도와 상관관계가 있습니다Research Article Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] activated acute respiratory distress acute respiratory distress syndrome ARDS Asymptomatic Bronchoalveolar lavage fluid cause CD16 CD38 CD44 Cell changed circulating circulation clinical disease Coagulation Coagulopathy contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Critical disease CXCR3 cytokine cytokine production D-dimer demonstrated develop disease severity disease status exhibiting expressing expression ferritin Frequency hospitalized COVID-19 patient IL-6 Immune cell immune cells immunology Inflammatory life-threatening low-density marker Mild MONITOR neutrophil Neutrophil extracellular traps Neutrophils Patient patients with COVID-19 phagocytic capacity Platelets Pneumonia Prognosis progression proinflammatory gene respiratory respiratory distress SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 severe COVID-19 subset Symptoms syndrome systemic inflammation These cells TNF-α upper respiratory tract venous Viral viral pathogen Viral pneumonia with COVID-19 [DOI] 10.1172/jci.insight.148435 PMC 바로가기 [Article Type] Research Article
Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model죽은 전체 게놈 감소 박테리아 표면 발현 코로나 바이러스 융합 펩티드 백신은 돼지 모델에서 질병으로부터 보호합니다423 Published on 2021-05-042022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Amino acid amino acid residues anamnestic response Bacteria Bacterial Betacoronavirus Cell cell surface clinical disease conserved core coronavirus coronavirus disease Coronavirus disease 2019 coronavirus vaccine COVID-19 cross-protection demonstrated diarrhea disease downstream Efficacy elicited ENhance epidemic diarrhea Escherichia coli evaluated Express expressing expression vector fusion peptide genome-reduced bacteria vaccine platform highly conserved fusion peptide immune system Immunity Interaction interferon interferon-γ offer pandemic Pathogens PEDV peptide PIGS platform porcine epidemic diarrhea virus (PEDV) principle proof PROTECT Protective provide provided reduced residue responses SARS-CoV-2 sequence Significance sterilizing immunity target tested tissue Transport upstream utility Vaccine vaccine antigen vaccine immunogenicity vaccine platform Vaccines viral RNA load virus whole-genome [DOI] 10.1073/pnas.2025622118 PMC 바로가기 [Article Type] 423
Comparative evaluation of semi-quantitative CT-severity scoring versus serum lactate dehydrogenase as prognostic biomarkers for disease severity and clinical outcome of COVID-19 patientsResearch Published on 2021-04-282022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] Accuracy Biomarker cause Chest clinical disease Clinical outcome Comparative Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 disease course COVID-19 disease severity COVID-19 patient COVID-19 patients Critical case critical cases Critical disease CT scan CT severity scoring cut-off value disease severity evaluate evaluated healthcare high mortality hospital Hospital admission identify investigated LDH medical resource Medical resources mild case Mortality Negative predictive value p value pandemic Patient positive positive RT-PCR Predictive prognostic prognostic biomarker Result retrospective risk semi-quantitative sensitivity serum serum lactate severe disease severity significantly higher specificity Support [DOI] 10.1186/s43055-021-00493-2 PMC 바로가기 [Article Type] Research
Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice감염성 클론은 감염된 K18-인간 ACE2 마우스에서 심각한 폐 질환을 일으키는 SARS-CoV-2를 생성합니다Research Article Published on 2021-04-202022-09-10 Journal: mBio [Category] MERS, SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 benefit Brain brains causative agent cause caused changes in clinical disease clinically clone consolidation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine development Cytokines develop effective facilitate feature Genetic hACE2 human ACE2 immunopathology in viral in vivo Infection infectious clones K18-hACE2 K18-hACE2 mice Laboratory lung Lung infection Lung pathology Lungs mCherry mice morbidity Mortality pandemic Pathogenesis Patient Pneumonia Postinfection Produce produced pulmonary Research respiratory respiratory viruses RG-rescued SARS-CoV-2 virus RG-rescued SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 research SARS-CoV-2 toolkit SARS-CoV-2-mCherry severe acute respiratory syndrome Coronavirus severe COVID-19 structures toolkit utility Validity valuable resource variety Viral Viral pneumonia viruses weight loss [DOI] 10.1128/mBio.00819-21 PMC 바로가기 [Article Type] Research Article
Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignanciesResearch Published on 2021-04-012022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] acute phase addition Analysis analyzed approach CD3+ CD38 CD4+ CD79B CD8+ T cells change clinical disease Coagulation coexistent consecutive patients coronavirus disease (COVID-19) correlated correlation count COVID-19 COVID-19 patient COVID-19 patients Critical CyTOF cytokine Cytometry demonstrated Differentially expressed genes disease effector memory expressed expression First wave Gene expression profiling group Hematological malignancies Hematological malignancy Hospitalized Host immune response IFIT3 IL-6 Immune cell immune response indicate Inflammation intensive care unit involved IP-10 leukemia LIPI Low T3 syndrome marker mononuclear cell multiplex NanoString NLR NLRP3 outbreak Patient patients with COVID-19 PBMC performed Peripheral blood Pneumonia presenting radiologic reduced reduction reported Result Rome SARS-CoV-2 serum Serum level serum levels severe COVID-19 severity single-cell SOFA subtype supplementary material syndrome T lymphocytes target gene the disease thyroid function tissue damage TSS university [DOI] 10.1186/s12967-021-02805-6 PMC 바로가기 [Article Type] Research
A meta-analysis of SARS-CoV-2 patients identifies the combinatorial significance of D-dimer, C-reactive protein, lymphocyte, and neutrophil values as a predictor of disease severitySARS-CoV-2 환자에 대한 메타 분석은 D-이량체, C-반응성 단백질, 림프구 및 호중구 값의 조합적 중요성을 질병 중증도의 예측 인자로 확인합니다Meta-Analysis Published on 2021-04-012022-09-11 Journal: International journal of laboratory hematology [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus article Blood C-reactive protein C-reactive protein (CRP causative agent CBC clinical disease clinical laboratory clinical variable clinical variables conducted coronavirus COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer D-dimer levels defined develop disease severity exhibited generate identify Interpretation Laboratory laboratory data Long-term follow-up lymphocyte Lymphocyte count lymphocyte counts median Meta-analysis Multiple Multiple regression analysis neutrophil neutrophil count observation outcome Patient patients with SARS-CoV-2 pediatric populations positive predictive values predicted Predictive predictive values progression regression analysis respiratory SARS-CoV-2 SARS-CoV-2 patient sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity specificity tested training set Univariate analysis validation cohort variable was performed worldwide pandemic [DOI] 10.1111/ijlh.13354 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma장 B 세포 림프종이 있는 이탈리아의 증상이 있는 고양이의 SARS-CoV-2 감염 및 항체 반응Case Reports Published on 2021-03-232022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] ( RdRP acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 antibody assumption B-cell lymphoma best cats Chain Reaction clinical condition clinical disease Clinical signs close contact Comorbidities Comorbidity companion animal condition contact with coronavirus coronavirus disease Coronavirus-2 cough COVID-19 detectable discharge disease domestic cat envelope Evidence gastrointestinal disease Human human-to-feline transmission IgG Immunoglobulin Infection intestinal investigated Italy knowledge molecular Neutralizing activity ocular oropharyngeal swab pandemic polymerase chain polymerase chain reaction positive provide RBD RdRP real-time reverse transcriptase Receptor binding domain reported respiratory respiratory tract response reverse transcriptase Reverse transcriptase polymerase chain reaction RNA-dependent RNA polymerase RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral RNA Serological testing serology Seropositivity severe acute respiratory syndrome Coronavirus sneeze susceptible sVNT tested Transmission Viral Virus neutralization [DOI] 10.3390/v13030527 PMC 바로가기 [Article Type] Case Reports
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolutionComparative Study Published on 2021-03-052022-10-04 Journal: Science Advances [Category] SARS, 바이오마커, 진단, [키워드] acute COVID-19 Affinity maturation antibody affinity Antibody binding antibody marker antibody repertoire antigenic clinical disease coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease severity effective epitope Evolution of SARS-CoV-2 faster fusion peptide IgA IgG immune marker immunodominant Immunoglobulin increase in knowledge Limited longitudinal maturation Mild Patient patients with COVID-19 prefusion RBD Receptor binding domain reveal SARS-COV-2 infection SARS-CoV-2 spike sequence severe COVID-19 [DOI] 10.1126/sciadv.abf2467 PMC 바로가기 [Article Type] Comparative Study
Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2SARS-CoV-2의 단일 균주의 비강 내 저용량으로 햄스터 및 흰 족제비 실험 감염Article Published on 2021-03-012022-09-11 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] Antiviral strategies Brain can be used clinical disease COVID-19 drugs excretion experimental animal model experimental model experimental models ferret ferrets French hamster hamsters immune response immune responses in vivo individual Infection infection levels inoculation intranasal Kinetics low dose lung Lungs Medulla oblongata Mild oblongata olfactory olfactory bulb Pathogenesis pathogenicity pathology protective effect remained resolved RNA SARS-CoV-2 SARS-COV-2 infection serological response severe disease severity the disease the SARS-CoV-2 therapeutic strategy understanding undetectable Viral Viral RNA virus [DOI] 10.1099/jgv.0.001567 PMC 바로가기 [Article Type] Article
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical diseaseCOVID-19 백신이 임상 질병을 악화시킬 위험이 있는 백신 시험 대상자에 대한 사전 동의 공개Article Published on 2021-03-012022-09-12 Journal: International journal of clinical practice [Category] MERS, SARS, 진단, [키워드] ADE Antibody-dependent enhancement approach approval approved circulating clinical clinical disease clinical evidence clinical trial clinician composed coronavirus COVID-19 COVID-19 disease COVID-19 vaccine COVID-19 vaccine trial Critical determine disease DNA elicit form identify Informed consent MERS Neutralising Antibodies neutralising antibody occur Patient Protein protocol recipient recruited Research Result risk risk of COVID-19 RNA RSV severe disease subject Trial trial protocol trials unlikely Vaccine vaccine trial viral spike Viral vector virus worsening [DOI] 10.1111/ijcp.13795 PMC 바로가기 [Article Type] Article