Endophytes: the novel sources for plant terpenoid biosynthesisEndophytes: 식물 테르페노이드 생합성을 위한 새로운 소스Review Published on 2021-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] SARS, 유전자 메커니즘, [키워드] antiviral activities applied Biosynthesis biosynthetic Biotransformation can not Cell Clinical treatment Compound compounds COVID-19 Endophyte Enzymes functions Genes heterologous expression Host IMPROVE in vivo International mechanism microbial Microbial cell factory multiomics plants platform Prevent problem Research resource Signal transduction strain Synthetic biology terpenoid Terpenoid. [DOI] 10.1007/s00253-021-11350-7 PMC 바로가기 [Article Type] Review
Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal CellsOpinion Published on 2021-06-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome alteration Analysis analyzed angiotensin-converting enzyme 2 approach Cell cell type cell types cells cellular tropism Clinical treatment coronavirus COVID-19 COVID-19 research Evidence expression Factors highlighting Human human tissue human tissues identity immune-inflammatory stromal cells indicated mechanism Older organ systems pathogen populations Research resource SARS-CoV-2 SARS-COV-2 infection scRNA-seq scRNA-seq data Single-cell RNA sequencing stromal cell TMPRSS2 TMPRSS2 expression transmembrane serine protease tropism viral entry viral pathogenesis viral tropism virus [DOI] 10.14336/AD.2021.0429 PMC 바로가기 [Article Type] Opinion
Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic strokeReview Published on 2021-05-312022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, [키워드] activated Activation approach Brain CIITA Clinical treatment complex component components death detect disease domain downstream drug dysfunction edema Effect effective Evidence genes encoding Immune cell increasingly Inflammasome Inflammation inflammatory pathways Inflammatory response inherent innate immune cell involved Ischemia Ischemic Stroke manuscript MAPK Mortality NAIP nerve cell NF-κB NLR NLRP3 NLRP3 inflammasome nuclear oligomerization pathogen invasion pathway pattern recognition receptor populations proinflammatory cytokines promote Protein PRR PRRs reactive oxygen species receptor signaling pathway stroke target therapeutic strategy therapy tissue damage Transcription understanding upstream [DOI] 10.1186/s12974-021-02137-8 PMC 바로가기 [Article Type] Review
The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID-19: Randomized Controlled TrialCOVID-19 환자의 우울 및 불안 증상에 대한 컴퓨터화된 인지 행동 치료의 효능: 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-142022-08-13 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] AIS antidepressants antiretroviral drug antiretroviral drugs Anxiety anxiety symptom assessment assessments Athens Insomnia Scale behavioral therapy carried CBT cCBT cCBT + TAU cCBT + TAU group cCBT intervention cCBT program Chinese clinical Clinical treatment cognitive behavioral therapy Computerized CBT computerized cognitive behavioral therapy Controlled COVID-19 COVID-19 pandemic Depression depressive drug Drug-to-drug interaction drug-to-drug interactions Effect effective Effectiveness Efficacy evaluate face-to-face therapy female FIVE follow-up period HAMA HAMD Hamilton Anxiety Scale Hamilton Depression Rating Scale Insomnia Intervention intervention program measure mental health middle school no significant difference no significant differences nonpharmacological treatment objective Patient patients with COVID-19 postintervention Prevalence Previous studies previous study psychological therapy Randomized Registration registry repeated measure Research Result Safe SAS scale scored Screening SDS secondary outcome measure secondary outcome measures Self-Rating Anxiety Scale Self-Rating Depression Scale shown significantly Symptom symptoms of depression Tau TAU group the patient therapist Treatment treatment as usual treatment method two groups were assessed [DOI] 10.2196/26883 PMC 바로가기 [Article Type] Randomized Controlled Trial
High-dose vitamin C intravenous infusion in the treatment of patients with COVID-19 A protocol for systematic review and meta-analysisCOVID-19 환자 치료에 고용량 비타민 C 정맥 주입 시스템적 검토 및 메타 분석을 위한 프로토콜 AMeta-Analysis Published on 2021-05-142022-09-10 Journal: Medicine [Category] SARS, 임상, [키워드] addition Antiviral effect China Chinese Chinese Biomedical Literature Database Clinical practice Clinical treatment comprehensive evaluation Controlled controlled trials COVID-19 criteria database Efficacy Efficacy and safety Evidence Guidance High-dose vitamin C inclusion/exclusion criteria Infrastructure intravenous intravenous infusion L-ascorbic acid lack literature Meta-analysis patients with COVID-19 protocol provided Randomized controlled trial Randomized controlled trials Registration registration number researcher researchers risk risk of bia searched systematic review treat Treatment virus Vitamin C was performed was used Web of Science [DOI] 10.1097/MD.0000000000025876 PMC 바로가기 [Article Type] Meta-Analysis
Updates in neonatal coronavirus disease 2019: What can we learn from detailed case reports? (Review)신생아 코로나바이러스 질병 2019 업데이트: 자세한 사례 보고서에서 무엇을 배울 수 있습니까? (검토)Review Published on 2021-05-012022-09-11 Journal: Molecular medicine reports [Category] SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Case report Characteristics China Chinese Clinical features Clinical treatment conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 demographic characteristics Direct English Epidemic facilitate Infrastructure Neonatal Neonate Prevention and control Prognosis ProQuest respiratory review Science Science Direct severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission Treatment Web of Science [DOI] 10.3892/mmr.2021.11990 PMC 바로가기 [Article Type] Review
The efficacy of reduced-visit prenatal care model during the coronavirus disease 2019 pandemic A protocol for systematic review and meta-analysis2019년 코로나바이러스 대유행 기간 동안 방문 감소 산전 관리 모델의 효능 체계적인 검토 및 메타 분석을 위한 프로토콜3800 Published on 2021-04-162022-08-31 Journal: Medicine [Category] Coronavirus, MERS, meta-analysis, SARS, [키워드] articles Care Clinical treatment collaboration Combination Controlled controlled trials coronavirus disease COVID-19 COVID-19 pandemic criteria data extraction Denmark Effectiveness Efficacy Evidence Guidance item lack medical subject heading Meta-analysis OSF outcome outcome measure outcome measures pandemic performed Pregnancy prenatal care PRISMA protocol reduced-visit prenatal care registration number reported Reporting review Satisfaction searched significance level Stress subject systematic review systematic reviews Version Web of Science while [DOI] 10.1097/MD.0000000000025435 PMC 바로가기 [Article Type] 3800
Efficacy of cognitive behavioral therapy on mood and quality of life for patients with COVID-19 A protocol for systematic review and meta-analysis인지행동치료가 코로나19 환자의 기분과 삶의 질에 미치는 영향 체계적인 검토 및 메타분석을 위한 프로토콜5000 Published on 2021-04-162022-08-31 Journal: Medicine [Category] COVID-19, MERS, meta-analysis, SARS, [키워드] “COVID-19 2019 coronavirus disease 2019-nCoV behavioral therapy CBT Clinical treatment Cochrane Library cognitive cognitive behavioral therapy cognitive behavioral treatment collaboration conducted Consistency coronavirus coronavirus disease COVID-19 COVID-19 epidemic criteria database Direct Effectiveness eligible Ethical approval Ethics Evidence Guidance include independent Intervention life Meta-analysis mood nCoV OSF outcome Patient patients with COVID-19 patients with COVID19 peer-reviewed protocol Psychological distress psychological health Quality of life registration number reported required resolved review risk of bia Science Science Direct searched Stress systematic review therapy Web of Science [DOI] 10.1097/MD.0000000000025512 PMC 바로가기 [Article Type] 5000
A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 PatientsReview Article Published on 2021-04-102022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] 95% confidence interval advanced age age article cardiovascular disease China chronic disease Chronic kidney disease chronic respiratory disease CIs Clinical treatment COVID-19 COVID-19 patients death death in COVID-19 diabete evaluated Factor help higher risk hypertension male Meta-analysis multiple comorbidities New coronavirus Odds ratio Patient patients review risk factor Risk factors Sex Web of Science [DOI] 10.1155/2021/6660930 PMC 바로가기 [Article Type] Review Article
Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challengeSARS-CoV-2 전염병 동안 동물 및 임상 연구 연결: 새로운 도전Review Published on 2021-04-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 비임상, 임상, 치료제, [키워드] accelerate animal model breath Bridging clinical evidence Clinical studies Clinical treatment clinical trial COVID-19 domain drug and vaccine development effort highlight human diseases limitation medical history pandemic Pandemics Pre-clinical research Research resource SARS-CoV-2 SARS-CoV-2 pandemic status strained synergy translational Trial utility Vaccine Vaccine development [DOI] 10.1016/j.ebiom.2021.103291 PMC 바로가기 [Article Type] Review