S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hot Spots, Functional Cross Talk, and Regulatory Interactions in SARS-CoV-2Research Article Published on 2021-02-232022-10-29 Journal: mSystems [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected affecting Amino acid Analysis angiotensin-converting enzyme 2 Antiviral binding caused clade co-occurrence Combination Comparative Comparative genomics Complete condition conditions contributing to coronavirus coronavirus disease country COVID-19 CpG D614G effective FIVE full-length genome functional annotation Genome Genomics geographical region highlighting host cell host proteins host-pathogen interaction hypoxia inhibiting Interaction membrane Mutation mutational studies MYO5A MYO5B MYO5C network network analysis novel nucleocapsid ORF8 pandemic pathogenicity pathway patients Phylogenomics Phylogeny polymorphism predicted Protein protein stability Proteins provided rate of infection receptor reduction in Region SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 virus screened Severity of infection single nucleotide SNP Spike protein strain Strains structural biology suggested the United State The United States thrombotic TMPRSS2 translation Transmissibility Transmission Treatment Variation Viral protein ZAP [DOI] 10.1128/mSystems.00030-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) GeneGenetics Published on 2021-02-192022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] A549 affecting Antiviral Asymptomatic Autopsy bioinformatics blood sample candidate gene changes in COVID-19 COVID-19 infection CpG described differentially expressed gene DNA DNA methylation DNMT1 DNMT3B downregulated Effect Epigenetic expression facilitate Genetic variation genomic healthy controls heat Host HSPA1L identify immune cells in silico in vitro model island lung lung epithelial cell Lung epithelial cells Methylation methyltransferase modulator mRNA expression NHBE Numerous promoter promoter region Prophylaxis regulated Regulation SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient significantly transcriptomic data Treatment ULBP2 upregulated upregulated genes viral replication was increased were used whole blood sample [DOI] 10.3389/fgene.2021.622271 PMC 바로가기 [Article Type] Genetics
A lymph node–targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2림프절 표적 양친매성 백신은 SARS-CoV-2에 대한 강력한 세포 및 체액 면역을 유도합니다Research Article Published on 2021-02-052022-09-12 Journal: Science Advances [Category] MERS, 진단, [키워드] ACE2 receptor binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alum amphiphile Antibody Response Antibody responses Antigen antigen-specific T cell candidate vaccine cellular composed consequence convalescent patient coronavirus COVID-19 CpG cytokine Cytokines dose reduction Effective vaccines ENhance evaluated humoral immune response humoral immune responses Humoral immunity IgG3 immune responses immunization induce isotype isotypes lung parenchyma lymph Lymph node lymph nodes mice Modification neutralized preserved produced Protein Protein subunit vaccines Receptor binding Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus spike T cell T cells T helper the SARS-CoV-2 titers translation Vaccine [DOI] 10.1126/sciadv.abe5819 PMC 바로가기 [Article Type] Research Article
Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine DesignSARS-CoV-2의 U 콘텐츠에 대한 강한 돌연변이 편향 및 선택에 대한 증거: 백신 설계에 대한 의미Discoveries Published on 2021-01-202022-09-10 Journal: Molecular Biology and Evolution [Category] 변종, 유전자 메커니즘, [키워드] accounting Analysis approach attenuation Bia Codons content CpG dinucleotide dinucleotides direction DNA vaccines Ebola Effect Engineering expected expression frequencies generalization generate H1N1 include indicate mechanism mRNA stability Mutation mutation equilibrium Neutral neutrality nucleotide observé profile quarter SARS-CoV-2 SARS-CoV-2 genes Selection Strong synonymous synonymous mutations synthesis turn Usage Vaccine Vaccine design Viral viral attenuation viral genes virus viruses Whole-genome sequence whole-genome sequences [DOI] 10.1093/molbev/msaa188 PMC 바로가기 [Article Type] Discoveries
The Long-Term Evolutionary History of Gradual Reduction of CpG Dinucleotides in the SARS-CoV-2 LineageCommunication Published on 2021-01-122022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory syndrome adaptation adaptive Amino acid Analysis Antiviral arginine Betacoronavirus bind caused clade coded coronavirus coronavirus disease correlation COVID-19 CpG CpG dinucleotide declining Defense deficiency Degradation dinucleotide dinucleotides evade examined fraction Frequency GC content Genome genomes genus Betacoronavirus Gradual history Host host defense investigated investigation Lineage mechanisms much higher Neutral nucleotide nucleotides occur occurred pandemic predicted proportion Protein recent reduced reduction in sarbecovirus SARS-CoV-2 Scientific community separated simple Specy suggested the Sarbecovirus the SARS-CoV-2 viral genome viral genomes Viral RNA virus Virus evolution zinc finger protein [DOI] 10.3390/biology10010052 PMC 바로가기 [Article Type] Communication
Coronavirus genomes carry the signatures of their habitats코로나 바이러스 게놈은 서식지의 서명을 가지고 있습니다Research Article Published on 2020-12-222022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundance Antiviral antiviral protein antiviral proteins Apolipoprotein B avoidance AVP bind Canis coronavirus CoV CpG Degradation dinucleotide effort enzyme evade Evolution Express facilitate generate Genome HIV-1 Homo Homo sapien Homo sapiens Host immune response host immune responses host immune system host tissue Hypothesis immune responses increase in infect infecting Infection Lupus MERS MHV motif mRNA Mus Mutation notable occur Protein residue SAME AS SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 vaccine selective pressure selective pressures sequence Seven Spread Temporal analysis tested the SARS-CoV-2 tissue tissues understanding variations Viral viral genome viral genomes viral transcript viral transcripts ZAP Zinc zinc finger antiviral protein [DOI] 10.1371/journal.pone.0244025 PMC 바로가기 [Article Type] Research Article
Genomic and evolutionary comparison between SARS-CoV-2 and other human coronavirusesArticle Published on 2020-12-052022-11-01 Journal: Journal of virological methods [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approach characterization clade Clustering codon codon usage complementary coronavirus COVID-19 CpG Dinucleotide suppression ecological niche Evolution genomic heterogeneity highly pathogenic Host human coronavirus human pathogen humans indicated infect Interaction MERS-CoV number pandemic pathogenicity Phylogenetic Phylogenetic analysis phylogenetics Phylogeny SARS-CoV SARS-CoV-2 SARS-CoV-2 genome trimer [DOI] 10.1016/j.jviromet.2020.114032 PMC 바로가기 [Article Type] Article
Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19Article Published on 2020-11-182022-10-04 Journal: Scientific Reports [Category] 변종, 치료기술, [키워드] addition Administered adverse effect aluminum applied candidate vaccine Combination COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 vaccine CpG cross-neutralize cytokine D614G variant development dominant elicited ENhance health emergency hydroxide immunized immunized mice immunology immunopathology lentivirus MERS-CoV mice Microbiology mitigate neutralizing antibody prefusion Prevent pseudotyped pseudovirus reporter S-2P SARS-CoV-2 spike antigen SARS-CoV-2 spike protein secreted sera splenocyte subunit Support Th1 the antibody the spike protein TLR9 Toll-like receptor Treatment two-dose regimen Vaccine was selected wild-type SARS-CoV-2 [DOI] 10.1038/s41598-020-77077-z PMC 바로가기 [Article Type] Article
Evolution of Transmissible Gastroenteritis Virus (TGEV): A Codon Usage PerspectiveArticle Published on 2020-10-242022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] adaptive addition Analysis Bayesian inference CAI coding sequence codon codon adaptation index codon usage Codon usage bias comprehensive analysis contribute coronavirus CpG current diarrhea dinucleotide dominant driving effective Evolution Genome Genotype high mortality indicated likelihood moderate Mutation mutation pressure natural selection nucleotide nucleotides parity Phylogenetic analysis Phylogeny principal component analysis rule selection pressure similarity subtype suggested synonymous TGEV transmissible gastroenteritis virus Usage was performed [DOI] 10.3390/ijms21217898 PMC 바로가기 [Article Type] Article